Professor William Alexander Donald

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W. Alexander��Donald is a Professor & ARC Future Fellow in the School of Chemistry at UNSW Sydney who is developing and applying analytical and mass spectrometry methodologies with an emphasis on problems in chemistry and biochemistry.

Graduate of University of California, Berkeley (Ph.D., 2010). Postdoctoral Fellow & Centenary Research Fellow, University of Melbourne (2010-2012). Lecturer, UNSW Sydney��(2013). Senior Lecturer, UNSW Sydney (2016). Associate Professor, UNSW Sydney (2020). ARC Future Fellowship (2020).��Scientia Associate Professor (2021). Professor (2024).

International Union of Pure and Applied Chemists Prize for Young Chemists (2011). New South Wales Fresh Science Finalist (2013). ARC Discovery Early Career Researcher Award (2013). Australian and New Zealand Society for Mass Spectrometry Michael Guilhaus Research Award (2015). RACI Physical Chemistry Division Lectureship (2016).��RACI Analytical and Environmental Chemistry Division Peter W. Alexander Medal (2016). Emerging Investigator, Analytical Methods (2015), The Analyst (2016), and The Journal of the American Society for Mass Spectrometry (2017). Australian and New Zealand Society for Mass Spectrometry Bowie Medal (2019). The Analytical Scientist 2020 Power List (2020).��ARC Future Fellowship (2020).

Vice President, Australian and New Zealand Society for Mass Spectrometry (2020-current). Past��Chair, RACI NSW Analytical and Environmental Chemistry Group (2020-current). Treasurer, Australian and New Zealand Society for Mass Spectrometry (2016-2020). Chair, RACI NSW Analytical and Environmental Chemistry Group (2017-2020). Member, ANZSMS and RACI.

Phone

+61-2-9385-8827

E-mail

w.donald@unsw.edu.au

Location

School of Chemistry University of New South Wales Science & Engineering Building (E8) Office 601, Level 6 Kensington Campus Sydney, NSW, 2052 Australia

Books | 2023

Donald WA; Supuran CT, 2023, Preface,

Books | 2023

Supuran CT; Donald WA, 2023, Metalloenzymes: From Bench to Bedside,
Book Chapters | 2023

Donald WA; Supuran CT, 2023, 'Introduction to metalloenzymes: From bench to bedside', in Metalloenzymes: From Bench to Bedside, pp. 3 - 5,

Book Chapters | 2022

Vermelho AB; Mori M; Donald WA; Supuran CT, 2022, 'Challenges and Promises for Obtaining New Antiprotozoal Drugs: What’s Going Wrong?', in Topics in Medicinal Chemistry, pp. 321 - 329,

Book Chapters | 2019

Donald WA; Prell JS, 2019, 'Preface', in Advances in Ion Mobility-Mass Spectrometry: Fundamentals, Instrumentation and Applications, Elsevier, pp. xiii - xiv,

Book Chapters | 2019

Nocentini A; Donald WA; Supuran CT, 2019, 'Chapter 8 Human carbonic anhydrases tissue distribution, physiological role, and druggability', in Carbonic Anhydrases, Elsevier, pp. 151 - 185,

Book Chapters | 2019

Nocentini A; Donald WA; Supuran CT, 2019, 'Human carbonic anhydrases: Tissue distribution, physiological role, and druggability', in Carbonic Anhydrases: Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target, pp. 151 - 185,

Book Chapters | 2019

Zhang JD; Mohibul Kabir KM; Donald WA, 2019, 'Ion-Mobility Mass Spectrometry for Chiral Analysis of Small Molecules', in , Elsevier, pp. 51 - 81,

Book Chapters | 2014

Donald WA; Williams ER, 2014, 'Measuring Absolute Single Half-Cell Reduction Potentials with Mass Spectrometry', in Bard AJ; Zoski CG (ed.), Electroanalytical Chemistry : A Series of Advances: Volume 25, CRC Press, Taylor & Francis Group, Boca Raton, FL, USA, pp. 1 - 32,

Book Chapters | 2013

Donald WA; Williams ER, 2013, 'Measuring absolute single half-cell reduction potentials with mass spectrometry', in Electroanalytical Chemistry: A Series of Advances: Volume 25, pp. 1 - 32,
Edited Books | 2019

Donald WA; Prell JS, 2019, Preface,
Journal articles | 2024

Angeli A; De Luca V; Huang X; Winter DL; Capasso C; Supuran CT; Donald WA, 2024, 'Phosphorylation strongly affects the inhibition of human carbonic anhydrase I CO2 hydration activity', Archives of Biochemistry and Biophysics, 761,

Journal articles | 2024

DiNardi RG; Rasheed S; Capomolla SS; Chak MH; Middleton IA; Macreadie LK; Violi JP; Donald WA; Lusby PJ; Beves JE, 2024, 'Photoswitchable Catalysis by a Self-Assembled Molecular Cage', Journal of the American Chemical Society, 146, pp. 21196 - 21202,

Journal articles | 2024

Lee CK; Feng Y; Tajik M; Violi JP; Donald WA; Stoddart JF; Kim DJ, 2024, 'Concise and Efficient Synthesis of Sequentially Isomeric Hetero[3]rotaxanes', Journal of the American Chemical Society, 146, pp. 27109 - 27116,

Journal articles | 2024

Lloyd Williams OH; Cox CS; Zhang MY; Lessio M; Rusli O; Donald WA; Jekimovs L; Marshall DL; Pfrunder MC; Poad BLJ; Brotin T; Rijs NJ, 2024, 'Cation induced changes to the structure of cryptophane cages', Dalton Transactions,

Journal articles | 2024

Pham PC; Taylor M; Nguyen GTH; Beltran J; Bennett JL; Ho J; Donald WA, 2024, 'Binding of Per- and Polyfluoroalkyl Substances to β-Lactoglobulin from Bovine Milk', Chemical Research in Toxicology, 37, pp. 757 - 770,

Journal articles | 2024

Winter DL; Wairara AR; Bennett JL; Donald WA; Glover DJ, 2024, 'Protein Interaction Kinetics Delimit the Performance of Phosphorylation-Driven Protein Switches', ACS Synthetic Biology, 13, pp. 1781 - 1797,

Journal articles | 2023

Bouza M; Ahmed E; Rocío-Bautista P; Brandt S; Franzke J; Molina-Díaz A; García-Reyes JF; Donald WA, 2023, 'Ion Heating in Advanced Dielectric Barrier Discharge Ion Sources for Ambient Mass Spectrometry', Journal of the American Society for Mass Spectrometry, 34, pp. 1145 - 1152,

Journal articles | 2023

Cao Z; Chi Y; Tang J; Esrafilzadeh D; Tang J; Rahim MA; Thomas DS; Tajik M; Donald WA; Kalantar-Zadeh K, 2023, 'Liquid metal enabled reformation of ethylene glycol', Chemical Engineering Journal, 460,

Journal articles | 2023

Huang X; Kamadurai H; Siuti P; Ahmed E; Bennett JL; Donald WA, 2023, 'Oligomeric Remodeling by Molecular Glues Revealed Using Native Mass Spectrometry and Mass Photometry', Journal of the American Chemical Society, 145, pp. 14716 - 14726,

Journal articles | 2023

Huang X; Winter D; Glover DJ; Supuran CT; Donald WA, 2023, 'Effects of Phosphorylation on the Activity, Inhibition and Stability of Carbonic Anhydrases', International Journal of Molecular Sciences, 24,

Journal articles | 2023

Jiang L; Dumlao MC; Donald WA; Steel CC; Schmidtke LM, 2023, 'Rapid In-Field Volatile Sampling for Detection of Botrytis cinerea Infection in Wine Grapes', Molecules, 28,

Journal articles | 2023

Jiang L; Qiu Y; Dumlao MC; Donald WA; Steel CC; Schmidtke LM, 2023, 'Detection and prediction of Botrytis cinerea infection levels in wine grapes using volatile analysis', Food Chemistry, 421,

Journal articles | 2023

Podgorski MN; Lee JHZ; Harbort JS; Nguyen GTH; Doherty DZ; Donald WA; Harmer JR; Bruning JB; Bell SG, 2023, 'Characterisation of the heme aqua-ligand coordination environment in an engineered peroxygenase cytochrome P450 variant', Journal of Inorganic Biochemistry, 249,

Journal articles | 2023

Ullah TR; Johansen MD; Balka KR; Ambrose RL; Gearing LJ; Roest J; Vivian JP; Sapkota S; Jayasekara WSN; Wenholz DS; Aldilla VR; Zeng J; Miemczyk S; Nguyen DH; Hansbro NG; Venkatraman R; Kang JH; Pang ES; Thomas BJ; Alharbi AS; Rezwan R; O’Keeffe M; Donald WA; Ellyard JI; Wong W; Kumar N; Kile BT; Vinuesa CG; Kelly GE; Laczka OF; Hansbro PM; De Nardo D; Gantier MP, 2023, 'Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection', Nature Communications, 14,

Journal articles | 2023

Zhang JD; Xue C; Kolachalama VB; Donald WA, 2023, 'Interpretable Machine Learning on Metabolomics Data Reveals Biomarkers for Parkinson's Disease', ACS Central Science, 9, pp. 1035 - 1045,

Journal articles | 2022

Bennett JL; Nguyen GTH; Donald WA, 2022, 'Protein-Small Molecule Interactions in Native Mass Spectrometry', Chemical Reviews, 122, pp. 7327 - 7385,

Journal articles | 2022

Brown SL; Zenaidee MA; Loo JA; Loo RRO; Donald WA, 2022, 'On the Mechanism of Theta Capillary Nanoelectrospray Ionization for the Formation of Highly Charged Protein Ions Directly from Native Solutions', Analytical Chemistry, 94, pp. 13010 - 13018,

Journal articles | 2022

DiNardi RG; Douglas AO; Tian R; Price JR; Tajik M; Donald WA; Beves JE, 2022, 'Visible-Light-Responsive Self-Assembled Complexes: Improved Photoswitching Properties by Metal Ion Coordination**', Angewandte Chemie - International Edition, 61, pp. e202205701,

Journal articles | 2022

Kabir KMM; Ahmed E; Donald WA, 2022, 'An atmospheric pressure ion funnel with a slit entrance for enhancing signal and resolution in high resolution differential ion mobility mass spectrometry', Analyst, 147, pp. 870 - 879,

Journal articles | 2022

Kabir KMM; Baker MJ; Donald WA, 2022, 'Micro- and nanoscale sensing of volatile organic compounds for early-stage cancer diagnosis', TrAC - Trends in Analytical Chemistry, 153,

Journal articles | 2022

Kennedy ADW; DiNardi RG; Fillbrook LL; Donald WA; Beves JE, 2022, 'Visible-Light Switching of Metallosupramolecular Assemblies**', Chemistry - A European Journal, 28, pp. e202104461,

Journal articles | 2022

Mastellone J; Kabir KMM; Huang X; Donald WA, 2022, 'Separation of disaccharide epimers, anomers and connectivity isomers by high resolution differential ion mobility mass spectrometry', Analytica Chimica Acta, 1206,

Journal articles | 2022

Podgorski MN; Harbort JS; Lee JHZ; Nguyen GTH; Bruning JB; Donald WA; Bernhardt PV; Harmer JR; Bell SG, 2022, 'An Altered Heme Environment in an Engineered Cytochrome P450 Enzyme Enables the Switch from Monooxygenase to Peroxygenase Activity', ACS Catalysis, 12, pp. 1614 - 1625,

Journal articles | 2022

Tajik M; Baharfar M; Donald WA, 2022, 'Single-cell mass spectrometry', Trends in Biotechnology, 40, pp. 1374 - 1392,

Journal articles | 2022

Zhang JD; Le MN; Hill KJ; Cooper AA; Stuetz RM; Donald WA, 2022, 'Identifying robust and reliable volatile organic compounds in human sebum for biomarker discovery', Analytica Chimica Acta, 1233,

Journal articles | 2022

2022, 'Visible‐Light‐Responsive Self‐Assembled Complexes: Improved Photoswitching Properties by Metal Ion Coordination**', Angewandte Chemie, 134,

Journal articles | 2021

Angeli A; Carta F; Nocentini A; Winum JY; Zalubovskis R; Onnis V; Eldehna WM; Capasso C; Carradori S; Donald WA; Dedhar S; Supuran CT, 2021, 'Response to Perspectives on the Classical Enzyme Carbonic Anhydrase and the Search for Inhibitors', Biophysical Journal, 120, pp. 178 - 181,

Journal articles | 2021

Becher S; Wang H; Leeming MG; Donald WA; Heiles S, 2021, 'Influence of protein ion charge state on 213 nm top-down UVPD', Analyst, 146, pp. 3977 - 3987,

Journal articles | 2021

Centurion F; Namivandi-Zangeneh R; Flores N; Tajik M; Merhebi S; Abbasi R; Mayyas M; Allioux FM; Tang J; Donald WA; Boyer C; Dickey MD; Kalantar-Zadeh K; Rahim MA, 2021, 'Liquid Metal-Triggered Assembly of Phenolic Nanocoatings with Antioxidant and Antibacterial Properties', ACS Applied Nano Materials, 4, pp. 2987 - 2998,

Journal articles | 2021

Chen X; Ching K; Rawal A; Lawes DJ; Tajik M; Donald WA; Zhao C; Lee SH; Ruoff RS, 2021, 'Stage-1 cationic C60 intercalated graphene oxide films', Carbon, 175, pp. 131 - 140,

Journal articles | 2021

Kho J; Pham PC; Kwon S; Huang AY; Rivers JP; Wang H; Ecroyd H; Donald WA; McAlpine SR, 2021, 'De Novo Design, Synthesis, and Mechanistic Evaluation of Short Peptides That Mimic Heat Shock Protein 27 Activity', ACS Medicinal Chemistry Letters, 12, pp. 713 - 719,

Journal articles | 2021

Liu Q; Ahmed E; Mohibul Kabir KM; Huang X; Xiao D; Fletcher J; Donald WA, 2021, 'Pulsed nanoelectrospray ionization boosts ion signal in whole protein mass spectrometry', Applied Sciences (Switzerland), 11,

Journal articles | 2021

Nguyen GTH; Bennett JL; Liu S; Hancock SE; Winter DL; Glover DJ; Donald WA, 2021, 'Multiplexed Screening of Thousands of Natural Products for Protein–Ligand Binding in Native Mass Spectrometry', Journal of the American Chemical Society, 143, pp. 21379 - 21387,

Journal articles | 2021

Nocentini A; Angeli A; Carta F; Winum JY; Zalubovskis R; Carradori S; Capasso C; Donald WA; Supuran CT, 2021, 'Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase', Journal of Enzyme Inhibition and Medicinal Chemistry, 36, pp. 561 - 580,

Journal articles | 2021

Queiroz RF; Stanley CP; Wolhuter K; Kong SMY; Rajivan R; McKinnon N; Nguyen GTH; Roveri A; Guttzeit S; Eaton P; Donald WA; Ursini F; Winterbourn CC; Ayer A; Stocker R, 2021, 'Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation', Nature Communications, 12,

Journal articles | 2021

Zhang JD; Baker MJ; Liu Z; Kabir KMM; Kolachalama VB; Yates DH; Donald WA, 2021, 'Medical diagnosis at the point-of-care by portable high-field asymmetric waveform ion mobility spectrometry: A systematic review and meta-analysis', Journal of Breath Research, 15,

Journal articles | 2020

Ahmed E; Xiao D; Dumlao MC; Steel CC; Schmidtke LM; Fletcher J; Donald WA, 2020, 'Nanosecond Pulsed Dielectric Barrier Discharge Ionization Mass Spectrometry', Analytical Chemistry, 92, pp. 4468 - 4474,

Journal articles | 2020

Ahmed E; Xiao D; Kabir KMM; Fletcher J; Donald WA, 2020, 'Ambient Pressure Ion Funnel: Concepts, Simulations, and Analytical Performance', Analytical Chemistry, 92, pp. 15811 - 15817,

Journal articles | 2020

Angeli A; Carta F; Nocentini A; Winum JY; Zalubovskis R; Akdemir A; Onnis V; Eldehna WM; Capasso C; Simone GD; Monti SM; Carradori S; Donald WA; Dedhar S; Supuran CT, 2020, 'Carbonic anhydrase inhibitors targeting metabolism and tumor microenvironment', Metabolites, 10, pp. 1 - 21,

Journal articles | 2020

Angeli A; Prete SD; Ghobril C; Hitce J; Clavaud C; Marrat X; Donald WA; Capasso C; Supuran CT, 2020, 'Activation studies of the β-carbonic anhydrases from Malassezia restricta with amines and amino acids', Journal of Enzyme Inhibition and Medicinal Chemistry, 35, pp. 824 - 830,

Journal articles | 2020

Leeming MG; Isaac AP; Zappia L; O'Hair RAJ; Donald WA; Pope BJ, 2020, 'HiTIME: An efficient model-selection approach for the detection of unknown drug metabolites in LC-MS data', SOFTWAREX, 12,

Journal articles | 2020

Miller ZM; Zhang JD; Donald WA; Prell JS, 2020, 'Gas-Phase Protonation Thermodynamics of Biological Lipids: Experiment, Theory, and Implications', Analytical Chemistry, 92, pp. 10365 - 10374,

Journal articles | 2020

Mori M; Capasso C; Carta F; Donald WA; Supuran CT, 2020, 'A deadly spillover: SARS-CoV-2 outbreak', Expert Opinion on Therapeutic Patents, 30, pp. 481 - 485,

Journal articles | 2020

Nguyen GTH; Leung WY; Tran TN; Wang H; Murray V; Donald WA, 2020, 'Mechanism for the Binding of Netropsin to Hairpin DNA Revealed Using Nanoscale Ion Emitters in Native Mass Spectrometry', Analytical Chemistry, 92, pp. 1130 - 1137,

Journal articles | 2020

Nguyen GTH; Nocentini A; Angeli A; Gratteri P; Supuran CT; Donald WA, 2020, 'Perfluoroalkyl Substances of Significant Environmental Concern Can Strongly Inhibit Human Carbonic Anhydrase Isozymes', Analytical Chemistry, 92, pp. 4614 - 4622,

Journal articles | 2020

Nocentini A; Del Prete S; Mastrolorenzo MD; Donald WA; Capasso C; Supuran CT, 2020, 'Activation studies of the β-carbonic anhydrases from Escherichia coli with amino acids and amines', Journal of Enzyme Inhibition and Medicinal Chemistry, 35, pp. 1379 - 1386,

Journal articles | 2020

Salbitani G; Del Prete S; Bolinesi F; Mangoni O; De Luca V; Carginale V; Donald WA; Supuran CT; Carfagna S; Capasso C, 2020, 'Use of an immobilised thermostable α-CA (SspCA) for enhancing the metabolic efficiency of the freshwater green microalga Chlorella sorokiniana', Journal of Enzyme Inhibition and Medicinal Chemistry, 35, pp. 913 - 920,

Journal articles | 2020

Suwannakot P; Lisi F; Ahmed E; Liang K; Babarao R; Gooding JJ; Donald WA, 2020, 'Metal-Organic Framework-Enhanced Solid-Phase Microextraction Mass Spectrometry for the Direct and Rapid Detection of Perfluorooctanoic Acid in Environmental Water Samples', Analytical Chemistry, 92, pp. 6900 - 6908,

Journal articles | 2020

Vullo D; Lehneck R; Donald WA; Pöggeler S; Supuran CT, 2020, 'Anion inhibition studies of the β-class carbonic anhydrase CAS3 from the filamentous ascomycete sordaria macrospora', Metabolites, 10,

Journal articles | 2020

Vullo D; Lehneck R; Donald WA; Pöggeler S; Supuran CT, 2020, 'Sulfonamide inhibition studies of the β-class carbonic anhydrase CAS3 from the filamentous ascomycete sordaria macrospora', Molecules, 25,

Journal articles | 2020

Wang H; Leeming MG; Cochran BJ; Hook JM; Ho J; Nguyen GTH; Zhong L; Supuran CT; Donald WA, 2020, 'Nontargeted Identification of Plasma Proteins O-, N-, and S-Transmethylated by O-Methyl Organophosphates', Analytical Chemistry, 92, pp. 15420 - 15428,

Journal articles | 2020

Zhang JD; Donor MT; Rolland AD; Leeming MG; Wang H; Trevitt AJ; Kabir KMM; Prell JS; Donald WA, 2020, 'Protonation isomers of highly charged protein ions can be separated in FAIMS-MS', International Journal of Mass Spectrometry, 457,

Journal articles | 2019

Ahmed E; Mohibul Kabir KM; Wang H; Xiao D; Fletcher J; Donald WA, 2019, 'Rapid separation of isomeric perfluoroalkyl substances by high-resolution differential ion mobility mass spectrometry', Analytica Chimica Acta, 1058, pp. 127 - 135,

Journal articles | 2019

Angeli A; Del Prete S; Osman SM; AlOthman Z; Donald WA; Capasso C; Supuran CT, 2019, 'Activation studies of the γ-carbonic anhydrases from the antarctic marine bacteria pseudoalteromonas haloplanktis and colwellia psychrerythraea with amino acids and amines', Marine Drugs, 17,

Journal articles | 2019

Angeli A; Del Prete S; Pinteala M; Maier SS; Donald WA; Simionescu BC; Capasso C; Supuran CT, 2019, 'The first activation study of the β-carbonic anhydrases from the pathogenic bacteria Brucella suis and Francisella tularensis with amines and amino acids', Journal of Enzyme Inhibition and Medicinal Chemistry, 34, pp. 1178 - 1185,

Journal articles | 2019

Boer SA; Cox RP; Beards MJ; Wang H; Donald WA; Bell TDM; Turner DR, 2019, 'Elucidation of naphthalene diimide metallomacrocycles and catenanes by solvent dependent excimer and exciplex emission', Chemical Communications, 55, pp. 663 - 666,

Journal articles | 2019

Boer SA; White KF; Slater B; Emerson AJ; Knowles GP; Donald WA; Thornton AW; Ladewig BP; Bell TDM; Hill MR; Chaffee AL; Abrahams BF; Turner DR, 2019, 'A Multifunctional, Charge-Neutral, Chiral Octahedral M12L12 Cage', Chemistry - A European Journal, 25, pp. 8489 - 8493,

Journal articles | 2019

Davies SR; Kankaew P; Tarrant GJ; Donald WA; Greaves RF, 2019, 'Comprehensive certification of a testosterone calibration standard facilitating the investigation of charged aerosol detection for the quantification of impurities of related structure', Metrologia, 56,

Journal articles | 2019

Foley EDB; Zenaidee MA; Tabor RF; Ho J; Beves JE; Donald WA; Bin Zenaidee M, 2019, 'On the mechanism of protein supercharging in electrospray ionisation mass spectrometry: Effects on charging of additives with short- and long-chain alkyl constituents with carbonate and sulphite terminal groups', Analytica Chimica Acta: X, 1, pp. Article no. 100004 - Article no. 100004,

Journal articles | 2019

Kennedy ADW; de Haas N; Iranmanesh H; Luis ET; Shen C; Wang P; Price JR; Donald WA; Andréasson J; Huang F; Beves JE, 2019, 'Diastereoselective Control of Tetraphenylethene Reactivity by Metal Template Self-Assembly', Chemistry - A European Journal, 25, pp. 5708 - 5718,

Journal articles | 2019

Khiabani PS; Soeriyadi AH; Nam EV; Peterson JR; Webb JEA; Thordarson P; Donald WA; Gooding JJ; Sowti Khiabani P, 2019, 'Understanding the performance of a paper-based UV exposure sensor: The photodegradation mechanism of brilliant blue FCF in the presence of TiO2 photocatalysts in both the solid state and solution', Rapid Communications in Mass Spectrometry, 33, pp. 1076 - 1083,

Journal articles | 2019

Leeming MG; Cranswick N; Wright CE; Ziogas J; O'Brien TJ; Donald WA; O'Hair RAJ, 2019, 'Using high-resolution Twin-Ion Metabolite Extraction (HiTIME) mass spectrometry with stable isotope labelling to investigate the metabolism of valproic acid in vivo', International Journal of Mass Spectrometry, 444,

Journal articles | 2019

Marlton SJP; McKinnon BI; Ucur B; Maccarone AT; Donald WA; Blanksby SJ; Trevitt AJ, 2019, 'Selecting and identifying gas-phase protonation isomers of nicotineH⁺ using combined laser, ion mobility and mass spectrometry techniques', Faraday Discussions, 217, pp. 453 - 475,

Journal articles | 2019

Nguyen GTH; Tran TN; Podgorski MN; Bell SG; Supuran CT; Donald WA, 2019, 'Nanoscale Ion Emitters in Native Mass Spectrometry for Measuring Ligand-Protein Binding Affinities', ACS Central Science, 5, pp. 308 - 318,

Journal articles | 2019

Wang H; Leeming MG; Ho J; Donald WA, 2019, 'Origin and Prediction of Highly Specific Bond Cleavage Sites in the Thermal Activation of Intact Protein Ions', Chemistry - A European Journal, 25, pp. 823 - 834,

Journal articles | 2019

Winter DL; Mastellone J; Kabir KMM; Wilkins MR; Donald WA, 2019, 'Separation of Isobaric Mono- And Dimethylated RGG-Repeat Peptides by Differential Ion Mobility-Mass Spectrometry', Analytical Chemistry, 91, pp. 11827 - 11833,

Journal articles | 2019

Winter DL; Wilkins MR; Donald WA, 2019, 'Differential Ion Mobility–Mass Spectrometry for Detailed Analysis of the Proteome', Trends in Biotechnology, 37, pp. 198 - 213,

Journal articles | 2018

Angeli A; Alasmary FAS; Del Prete S; Osman SM; AlOthman Z; Donald WA; Capasso C; Supuran CT, 2018, 'The first activation study of a δ-carbonic anhydrase: TweCAδ from the diatom Thalassiosira weissflogii is effectively activated by amines and amino acids', Journal of Enzyme Inhibition and Medicinal Chemistry, 33, pp. 680 - 685,

Journal articles | 2018

Angeli A; Buonanno M; Donald WA; Monti SM; Supuran CT, 2018, 'The zinc – but not cadmium – containing ζ-carbonic from the diatom Thalassiosira weissflogii is potently activated by amines and amino acids', Bioorganic Chemistry, 80, pp. 261 - 265,

Journal articles | 2018

Angeli A; Del Prete S; Alasmary FAS; Alqahtani LS; AlOthman Z; Donald WA; Capasso C; Supuran CT, 2018, 'The first activation studies of the η-carbonic anhydrase from the malaria parasite Plasmodium falciparum with amines and amino acids', Bioorganic Chemistry, 80, pp. 94 - 98,

Journal articles | 2018

Angeli A; Del Prete S; Donald WA; Capasso C; Supuran CT, 2018, 'The γ-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae is potently activated by amines and amino acids', Bioorganic Chemistry, 77, pp. 1 - 5,

Journal articles | 2018

Angeli A; Del Prete S; Osman SM; Alasmary FAS; AlOthman Z; Donald WA; Capasso C; Supuran CT, 2018, 'Activation studies of the α- and β-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae with amines and amino acids', Journal of Enzyme Inhibition and Medicinal Chemistry, 33, pp. 227 - 233,

Journal articles | 2018

Angeli A; Del Prete S; Osman SM; Alasmary FAS; AlOthman Z; Donald WA; Capasso C; Supuran CT, 2018, 'Activation studies with amines and amino acids of the β-carbonic anhydrase encoded by the Rv3273 gene from the pathogenic bacterium Mycobacterium tuberculosis', Journal of Enzyme Inhibition and Medicinal Chemistry, 33, pp. 364 - 369,

Journal articles | 2018

Angeli A; Donald WA; Parkkila S; Supuran CT, 2018, 'Activation studies with amines and amino acids of the β-carbonic anhydrase from the pathogenic protozoan Leishmania donovani chagasi', Bioorganic Chemistry, 78, pp. 406 - 410,

Journal articles | 2018

Angeli A; Tanini D; Capperucci A; Supuran CT, 2018, 'First evaluation of organotellurium derivatives as carbonic anhydrase I, II, IV, VII and IX inhibitors', BIOORGANIC CHEMISTRY, 76, pp. 268 - 272,

Journal articles | 2018

Berry T; Dutta D; Renxun C; Andrea A; Huixin W; William D; Maryam P; Willcox MARKDUNCAN; Kumar NARESH; Cranfield CHARLES, 2018, 'The lipid membrane interactions of the cationic antimicrobial peptide chimeras melimine and cys-melimine', Langmuir

Journal articles | 2018

Bua S; Bozdag M; Del Prete S; Carta F; Donald WA; Capasso C; Supuran CT, 2018, 'Mono- and di-thiocarbamate inhibition studies of the δ-carbonic anhydrase TweCAδ from the marine diatom Thalassiosira weissflogii', Journal of Enzyme Inhibition and Medicinal Chemistry, 33, pp. 707 - 713,

Journal articles | 2018

Donald KE; Kabir KMM; Donald WA, 2018, 'Tips for reading patents: a concise introduction for scientists', Expert Opinion on Therapeutic Patents, 28, pp. 277 - 280,

Journal articles | 2018

Kabir KMM; Donald WA, 2018, 'Cancer breath testing: a patent review', Expert Opinion on Therapeutic Patents, 28, pp. 227 - 239,

Journal articles | 2018

Luis ET; Iranmanesh H; Arachchige KSA; Donald WA; Quach G; Moore EG; Beves JE, 2018, 'Luminescent Tetrahedral Molecular Cages Containing Ruthenium(II) Chromophores', Inorganic Chemistry, 57, pp. 8476 - 8486,

Journal articles | 2018

Sapegin A; Kalinin S; Angeli A; Supuran CT; Krasavin M, 2018, 'Unprotected primary sulfonamide group facilitates ring-forming cascade en route to polycyclic [1,4]oxazepine-based carbonic anhydrase inhibitors', BIOORGANIC CHEMISTRY, 76, pp. 140 - 146,

Journal articles | 2018

Stefanucci A; Angeli A; Dimmito MP; Luisi G; Del Prete S; Capasso C; Donald WA; Mollica A; Supuran CT, 2018, 'Activation of β- and γ-carbonic anhydrases from pathogenic bacteria with tripeptides', Journal of Enzyme Inhibition and Medicinal Chemistry, 33, pp. 945 - 950,

Journal articles | 2018

Vullo D; Del Prete S; Osman SM; Alasmary FAS; AlOthman Z; Donald WA; Capasso C; Supuran CT, 2018, 'Comparison of the amine/amino acid activation profiles of the β- and γ-carbonic anhydrases from the pathogenic bacterium Burkholderia pseudomallei', Journal of Enzyme Inhibition and Medicinal Chemistry, 33, pp. 25 - 30,

Journal articles | 2018

Wang H; Yong G; Brown SL; Lee HE; Zenaidee MA; Supuran CT; Donald WA, 2018, 'Supercharging protein ions in native mass spectrometry using theta capillary nanoelectrospray ionization mass spectrometry and cyclic alkylcarbonates', Analytica Chimica Acta, 1003, pp. 1 - 9,

Journal articles | 2018

Zhang JD; Kabir KMM; Donald WA, 2018, 'Metal-ion free chiral analysis of amino acids as small as proline using high-definition differential ion mobility mass spectrometry', Analytica Chimica Acta, 1036, pp. 172 - 178,

Journal articles | 2018

Zhang JD; Mohibul Kabir KM; Lee HE; Donald WA, 2018, 'Chiral recognition of amino acid enantiomers using high-definition differential ion mobility mass spectrometry', International Journal of Mass Spectrometry, 428, pp. 1 - 7,

Journal articles | 2017

Del Prete S; Vullo D; Di Fonzo P; Osman SM; AlOthman Z; Donald WA; Supuran CT; Capasso C, 2017, 'Sulfonamide inhibition profile of the γ-carbonic anhydrase identified in the genome of the pathogenic bacterium Burkholderia pseudomallei the etiological agent responsible of melioidosis', Bioorganic and Medicinal Chemistry Letters, 27, pp. 490 - 495,

Journal articles | 2017

Del Prete S; Vullo D; Osman SM; AlOthman Z; Donald WA; Winum JY; Supuran CT; Capasso C, 2017, 'Anion inhibitors of the β-carbonic anhydrase from the pathogenic bacterium responsible of tularemia, Francisella tularensis', Bioorganic and Medicinal Chemistry, 25, pp. 4800 - 4804,

Journal articles | 2017

Donor MT; Ewing SA; Zenaidee MA; Donald WA; Prell JS, 2017, 'Extended Protein Ions Are Formed by the Chain Ejection Model in Chemical Supercharging Electrospray Ionization', Analytical Chemistry, 89, pp. 5107 - 5114,

Journal articles | 2017

Dumlao M; Khairallah GN; Donald WA, 2017, 'Internal energy deposition in dielectric barrier discharge ionization is significantly lower than in direct analysis in real-time mass spectrometry', Australian Journal of Chemistry, 70, pp. 1219 - 1226,

Journal articles | 2017

Dumlao MC; Xiao D; Zhang D; Fletcher J; Donald WA, 2017, 'Effects of Different Waveforms on the Performance of Active Capillary Dielectric Barrier Discharge Ionization Mass Spectrometry', Journal of the American Society for Mass Spectrometry, 28, pp. 575 - 578,

Journal articles | 2017

Iranmanesh H; Arachchige KSA; Donald WA; Kyriacou N; Shen C; Price JR; Beves JE, 2017, 'Rage Against Conformity: Ruthenium(II) Bisterpyridine Complexes Respond to Crystal Engineering Instructions with Whelming Results', Australian Journal of Chemistry, 70, pp. 529 - 537,

Journal articles | 2017

Kabir KMM; Donald WA, 2017, 'Microscale differential ion mobility spectrometry for field deployable chemical analysis', TrAC - Trends in Analytical Chemistry, 97, pp. 399 - 427,

Journal articles | 2017

Leeming MG; Donald WA; O'Hair RAJ, 2017, 'Nontargeted Identification of Reactive Metabolite Protein Adducts', Analytical Chemistry, 89, pp. 5748 - 5756,

Journal articles | 2017

Shen C; Kennedy ADW; Donald WA; Torres AM; Price WS; Beves JE, 2017, 'Self-assembled supramolecular cages containing dinuclear ruthenium(II) polypyridyl complexes', Inorganica Chimica Acta, 458, pp. 122 - 128,

Journal articles | 2017

Vullo D; Del Prete S; Di Fonzo P; Carginale V; Donald WA; Supuran CT; Capasso C, 2017, 'Comparison of the sulfonamide inhibition profiles of the β- And γ-carbonic anhydrases from the pathogenic bacterium burkholderia pseudomallei', Molecules, 22, pp. 421,

Journal articles | 2017

Vullo D; Del Prete S; Osman SM; AlOthman Z; Capasso C; Donald WA; Supuran CT, 2017, 'Burkholderia pseudomallei γ-carbonic anhydrase is strongly activated by amino acids and amines', Bioorganic and Medicinal Chemistry Letters, 27, pp. 77 - 80,

Journal articles | 2017

Wegeberg C; Donald WA; McKenzie CJ, 2017, 'Noncovalent Halogen Bonding as a Mechanism for Gas-Phase Clustering', Journal of the American Society for Mass Spectrometry, 28, pp. 2209 - 2216,

Journal articles | 2017

Zenaidee MA; Leeming MG; Zhang F; Funston TT; Donald WA, 2017, 'Highly Charged Protein Ions: The Strongest Organic Acids to Date', Angewandte Chemie - International Edition, 56, pp. 8522 - 8526,

Journal articles | 2017

Zenaidee MA; Leeming MG; Zhang F; Funston TT; Donald WA, 2017, 'Highly Charged Protein Ions: The Strongest Organic Acids to Date', Angewandte Chemie, 129, pp. 8642 - 8646,

Journal articles | 2017

Zenaidee MA; Leeming MG; Zhang F; Funston TT; Donald WA, 2017, 'Innentitelbild: Highly Charged Protein Ions: The Strongest Organic Acids to Date (Angew. Chem. 29/2017)', Angewandte Chemie, 129, pp. 8418 - 8418,

Journal articles | 2017

Zenaidee MA; Leeming MG; Zhang F; Funston TT; Donald WA, 2017, 'Inside Cover: Highly Charged Protein Ions: The Strongest Organic Acids to Date (Angew. Chem. Int. Ed. 29/2017)', Angewandte Chemie International Edition, 56, pp. 8302 - 8302,

Journal articles | 2016

De Sousa DP; Wegeberg C; Vad MS; Mørup S; Frandsen C; Donald WA; McKenzie CJ, 2016, 'Halogen-Bonding-Assisted Iodosylbenzene Activation by a Homogenous Iron Catalyst', Chemistry - A European Journal, 22, pp. 3810 - 3820,

Journal articles | 2016

Dumlao MC; Jeffress LE; Gooding JJ; Donald WA, 2016, 'Solid-phase microextraction low temperature plasma mass spectrometry for the direct and rapid analysis of chemical warfare simulants in complex mixtures', Analyst, 141, pp. 3714 - 3721,

Journal articles | 2016

Iranmanesh H; Arachchige KSA; Bhadbhade M; Donald WA; Liew JY; Liu KTC; Luis ET; Moore EG; Price JR; Yan H; Yang J; Beves JE, 2016, 'Chiral Ruthenium(II) Complexes as Supramolecular Building Blocks for Heterometallic Self-Assembly', Inorganic Chemistry, 55, pp. 12737 - 12751,

Journal articles | 2015

Leeming MG; Gamon LF; Wille U; Donald WA; O'Hair RAJ, 2015, 'What Are the Potential Sites of Protein Arylation by N-Acetyl-p-benzoquinone Imine (NAPQI)?', Chemical Research in Toxicology, 28, pp. 2224 - 2233,

Journal articles | 2015

Leeming MG; Isaac AP; Pope BJ; Cranswick N; Wright CE; Ziogas J; O'Hair RAJ; Donald WA, 2015, 'High-resolution twin-ion metabolite extraction (HiTIME) mass spectrometry: Nontargeted detection of unknown drug metabolites by isotope labeling, liquid chromatography mass spectrometry, and automated high-performance computing', Analytical Chemistry, 87, pp. 4104 - 4109,

Journal articles | 2015

Stephens ER; Dumlao M; Xiao D; Zhang D; Donald WA, 2015, 'Benzylammonium Thermometer Ions: Internal Energies of Ions Formed by Low Temperature Plasma and Atmospheric Pressure Chemical Ionization', Journal of the American Society for Mass Spectrometry, 26, pp. 2081 - 2084,

Journal articles | 2015

Stephens ER; Dumlao M; Xiao D; Zhang D; Donald WA, 2015, 'Erratum: Benzylammonium Thermometer Ions: Internal Energies of Ions Formed by Low Temperature Plasma and Atmospheric Pressure Chemical Ionization (Journal of the American Society for Mass Spectrometry (2015) DOI: 10.1007/s13361-015-1272-1))', Journal of the American Society for Mass Spectrometry, 26, pp. 2085,

Journal articles | 2015

Yang J; Bhadbhade M; Donald WA; Iranmanesh H; Moore EG; Yan H; Beves JE, 2015, 'Self-assembled supramolecular cages containing ruthenium(ii) polypyridyl complexes', Chemical Communications, 51, pp. 4465 - 4468,

Journal articles | 2015

Zenaidee MA; Donald WA, 2015, 'Electron capture dissociation of extremely supercharged protein ions formed by electrospray ionisation', Analytical Methods, 7, pp. 7132 - 7139,

Journal articles | 2015

Zenaidee MA; Donald WA, 2015, 'Extremely supercharged proteins in mass spectrometry: Profiling the pH of electrospray generated droplets, narrowing charge state distributions, and increasing ion fragmentation', Analyst, 140, pp. 1894 - 1905,

Journal articles | 2014

Hoi KK; Daborn PJ; Battlay P; Robin C; Batterham P; O'Hair RAJ; Donald WA, 2014, 'Dissecting the insect metabolic machinery using twin ion mass spectrometry: A single P450 enzyme metabolizing the insecticide imidacloprid in vivo', Analytical Chemistry, 86, pp. 3525 - 3532,

Journal articles | 2014

Leeming MG; White JM; O'Hair RAJ; Donald WA, 2014, 'Mobile proton triggered radical fragmentation of nitroarginine containing peptides', Journal of the American Society for Mass Spectrometry, 25, pp. 427 - 438,

Journal articles | 2014

Teo CA; Donald WA, 2014, 'Solution additives for supercharging proteins beyond the theoretical maximum proton-transfer limit in electrospray ionization mass spectrometry', Analytical Chemistry, 86, pp. 4455 - 4462,

Journal articles | 2013

Donald W; Khairallah GN; O'Hair RAJ, 2013, 'The effective temperature of ions stored in a linear quadrupole ion trap mass spectrometer', Journal of the American Society for Mass Spectrometry, 24, pp. 811 - 815,

Journal articles | 2013

Flick TG; Donald WA; Williams ER, 2013, 'Electron capture dissociation of trivalent metal ion-peptide complexes', Journal of the American Society for Mass Spectrometry, 24, pp. 193 - 201,

Journal articles | 2012

Donald WA; Leeming MG; O'Hair RAJ, 2012, 'Gas-phase ion chemistry of the pesticide imidacloprid: Proton driven radical fragmentation of the nitro-guanidine functional group', International Journal of Mass Spectrometry, 316-318, pp. 91 - 99,

Journal articles | 2012

Donald WA; O'Hair RAJ, 2012, 'Shapeshifting: Ligation by 1,4-cyclohexadiene induces a structural change in Ag 5⁺', Dalton Transactions, 41, pp. 3185 - 3193,

Journal articles | 2011

Donald WA; Leib RD; Demireva M; Negru B; Neumark DM; Williams ER, 2011, 'Average sequential water molecule binding enthalpies of M(H 2O)19-124²⁺ (M = Co, Fe, Mn, and Cu) measured with ultraviolet photodissociation at 193 and 248 nm', Journal of Physical Chemistry A, 115, pp. 2 - 12,

Journal articles | 2011

Donald WA; Leib RD; Demireva M; Williams ER, 2011, 'Ions in size-selected aqueous nanodrops: Sequential water molecule binding energies and effects of water on ion fluorescence', Journal of the American Chemical Society, 133, pp. 18940 - 18949,

Journal articles | 2011

Donald WA; McKenzie CJ; O'Hair RAJ, 2011, 'C-H bond activation of methanol and ethanol by a high-spin Fe^IVO biomimetic complex', Angewandte Chemie - International Edition, 50, pp. 8379 - 8383,

Journal articles | 2011

Donald WA; McKenzie CJ; O'Hair RAJ, 2011, 'CH Bond Activation of Methanol and Ethanol by a High‐Spin Fe^IVO Biomimetic Complex', Angewandte Chemie, 123, pp. 8529 - 8533,

Journal articles | 2011

Donald WA; Williams ER, 2011, 'Gas-phase electrochemistry: Measuring absolute potentials and investigating ion and electron hydration', Pure and Applied Chemistry, 83, pp. 2129 - 2151,

Journal articles | 2010

Donald WA; Demireva M; Leib RD; Aiken MJ; Williams ER, 2010, 'Electron hydration and ion-electron pairs in water clusters containing trivalent metal ions', Journal of the American Chemical Society, 132, pp. 4633 - 4640,

Journal articles | 2010

Donald WA; Leib RD; Demireva M; Negru B; Neumark DM; Williams ER, 2010, 'Weighing photon energies with mass spectrometry: Effects of water on ion fluorescence', Journal of the American Chemical Society, 132, pp. 6904 - 6905,

Journal articles | 2010

Donald WA; Williams ER, 2010, 'An improved cluster pair correlation method for obtaining the absolute proton hydration energy and enthalpy evaluated with an expanded data set', Journal of Physical Chemistry B, 114, pp. 13189 - 13200,

Journal articles | 2010

Donald WA; Williams ER, 2010, 'Measuring the Extent and Width of Internal Energy Deposition in Ion Activation Using Nanocalorimetry', Journal of the American Society for Mass Spectrometry, 21, pp. 615 - 625,

Journal articles | 2009

Donald WA; Leib RD; Demireva M; O'Brien JT; Prell JS; Williams ER, 2009, 'Directly relating reduction energies of gaseous Eu(H2O) n³⁺, n = 55-140, to aqueous solution: The absolute SHE potential and real proton solvation energy', Journal of the American Chemical Society, 131, pp. 13328 - 13337,

Journal articles | 2009

Donald WA; Leib RD; O'Brien JT; Williams ER, 2009, 'Cover Picture: Directly Relating Gas‐Phase Cluster Measurements to Solution‐Phase Hydrolysis, the Absolute Standard Hydrogen Electrode Potential, and the Absolute Proton Solvation Energy (Chem. Eur. J. 24/2009)', Chemistry – A European Journal, 15, pp. 5863 - 5863,

Journal articles | 2009

Donald WA; Leib RD; O'Brien JT; Williams ER, 2009, 'Directly relating gas-phase cluster measurements to solution-phase hydrolysis, the absolute standard hydrogen electrode potential, and the absolute proton solvation energy', Chemistry - A European Journal, 15, pp. 5926 - 5934,

Journal articles | 2008

Donald WA; Leib RD; O'Brien JT; Bush MF; Williams ER, 2008, 'Absolute standard hydrogen electrode potential measured by reduction of aqueous nanodrops in the gas phase', Journal of the American Chemical Society, 130, pp. 3371 - 3381,

Journal articles | 2008

Donald WA; Leib RD; O'Brien JT; Holm AIS; Williams ER, 2008, 'Nanocalorimetry in mass spectrometry: A route to understanding ion and electron solvation', Proceedings of the National Academy of Sciences of the United States of America, 105, pp. 18102 - 18107,

Journal articles | 2008

Donald WA; Williams ER, 2008, 'Evaluation of different implementations of the thomson liquid drop model: Comparison to monovalent and divalent cluster ion experimental data', Journal of Physical Chemistry A, 112, pp. 3515 - 3522,

Journal articles | 2008

Holm AIS; Donald WA; Hvelplund P; Larsen MK; Nielsen SB; Williams ER, 2008, 'Investigation of energy deposited by femtosecond electron transfer in collisions using hydrated ion nanocalorimetry', Journal of Physical Chemistry A, 112, pp. 10721 - 10727,

Journal articles | 2008

Holm AIS; Larsen MK; Panja S; Hvelplund P; Nielsen SB; Leib RD; Donald WA; Williams ER; Hao C; Tureček F, 2008, 'Electron capture, femtosecond electron transfer and theory: A study of noncovalent crown ether 1,n-diammonium alkane complexes', International Journal of Mass Spectrometry, 276, pp. 116 - 126,

Journal articles | 2008

Prell JS; O'Brien JT; Holm AIS; Leib RD; Donald WA; Williams ER, 2008, 'Electron capture by a hydrated gaseous peptide: Effects of water on fragmentation and molecular survival', Journal of the American Chemical Society, 130, pp. 12680 - 12689,

Journal articles | 2007

Leib RD; Donald WA; Bush MF; O'Brien JT; Williams ER, 2007, 'Internal energy deposition in electron capture dissociation measured using hydrated divalent metal ions as nanocalorimeters', Journal of the American Chemical Society, 129, pp. 4894 - 4895,

Journal articles | 2007

Leib RD; Donald WA; Bush MF; O'Brien JT; Williams ER, 2007, 'Nonergodicity in Electron Capture Dissociation Investigated Using Hydrated Ion Nanocalorimetry', Journal of the American Society for Mass Spectrometry, 18, pp. 1217 - 1231,

Journal articles | 2007

Leib RD; Donald WA; O'Brien JT; Bush MF; Williams ER, 2007, 'Reduction energy of 1 M aqueous ruthenium(III) hexaammine in the gas phase: A route toward establishing an absolute electrochemical scale', Journal of the American Chemical Society, 129, pp. 7716 - 7717,

Journal articles | 2007

McLaughlin RP; Donald WA; Jitjai D; Zhang Y, 2007, 'Vibrational analysis of n-butyl, isobutyl, sec-butyl and tert-butyl nitrite', Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 67, pp. 178 - 187,
Working Papers | 2021

Kennedy A; DiNardi R; Fillbrook L; Donald W; Beves J, 2021, Visible light switching of metallosupramolecular assemblies, ,
Preprints | 2024

Angeli A; De Luca V; Huang X; Winter D; Capasso C; Supuran C; Donald W, 2024, Phosphorylation Strongly Affects the Inhibition of Human Carbonic Anhydrase I CO2 Hydration Activity,

Preprints | 2024

Baker MJ; Gordon J; Thiruvarudchelvan A; Yates D; Donald WA, 2024, Rapid, Non-Invasive Breath Analysis for Enhancing Detection of Silicosis Using Mass Spectrometry and Interpretable Machine Learning,

Preprints | 2024

DiNardi RG; Rasheed S; Capomolla SS; Chak MH; Middleton IA; Macreadie LK; Violi JP; Donald WA; Lusby PJ; Beves JE, 2024, Photoswitchable catalysis by a self-assembled molecular cage,

Preprints | 2024

DiNardi RG; Rasheed S; Capomolla SS; Chak MH; Middleton IA; Macreadie LK; Violi JP; Donald WA; Lusby PJ; Beves JE, 2024, Photoswitchable catalysis by a self-assembled molecular cage,

Preprints | 2024

DiNardi RG; Rasheed S; Capomolla SS; Chak MH; Middleton IA; Macreadie LK; Violi JP; Donald WA; Lusby PJ; Beves JE, 2024, Photoswitchable catalysis by a self-assembled molecular cage,

Preprints | 2024

DiNardi RG; Rasheed S; Capomolla SS; Chak MH; Middleton IA; Macreadie LK; Violi JP; Donald WA; Lusby PJ; Beves JE, 2024, Photoswitchable catalysis by a self-assembled molecular cage, ,

Preprints | 2024

DiNardi RG; Rasheed S; Capomolla SS; Chak MH; Middleton IA; Macreadie LK; Violi JP; Donald WA; Lusby PJ; Beves JE, 2024, Photoswitchable catalysis by a self-assembled molecular cage, ,

Preprints | 2024

Hua L; Solomon M; D'Alessandro D; Donald W, 2024, Metal-Organic Frameworks for the Trace Multiplexed Adsorption and Quantitation of 50 Per- and Polyfluoroalkyl Substances,

Preprints | 2023

Huang X; Kamadurai H; Siuti P; Ahmed E; Bennett J; Donald W, 2023, Oligomeric remodelling by molecular glues revealed using native mass spectrometry and mass photometry, ,

Preprints | 2023

Huang X; Winter D; Glover D; Supuran C; Donald W, 2023, Effects of phosphorylation on the activity, inhibition and stability of carbonic anhydrases, ,

Preprints | 2023

Jiang L; Dumlao MC; Donald WA; Steel CC; Schmidtke LM, 2023, Rapid In-Field Volatile Sampling for Detection and Quantification of Botrytis cinerea Infection in Wine Grapes,

Preprints | 2023

Jiang L; QIU Y; DUMLAO MC; DONALD WA; STEEL CC; SCHMIDTKE LM, 2023, Prediction of Botrytis Cinerea Infection Levels in Wine Grapes Using Headspace Spme Gc-Ms Volatile Analysis, ,

Preprints | 2023

Pham PC; Taylor M; Nguyen G; Beltran J; Bennett J; Ho J; Donald W, 2023, Binding of Per- and Polyfluoroalkyl Substances to β-Lactoglobulin from Bovine Milk, ,

Preprints | 2023

Pham PC; Taylor M; Nguyen G; Beltran J; Bennett J; Ho J; Donald W, 2023, Binding of Per- and Polyfluoroalkyl Substances to β-Lactoglobulin from Bovine Milk, ,

Preprints | 2023

Winter D; Wairara A; Bennett J; Donald W; Glover D, 2023, Protein interaction kinetics delimit the performance of phosphorylation-driven protein switches, ,

Preprints | 2022

Brown S; Zenaidee M; Loo J; Ogorzalek Loo R; Donald W, 2022, On the mechanism of theta capillary nanoelectrospray ionization for the formation of highly charged protein ions directly from native solutions,

Preprints | 2022

DiNardi R; Douglas AO; Tian R; Price J; Tajik M; Donald WA; Beves J, 2022, Visible-light-responsive self-assembled complexes: improved photoswitching properties by metal ion coordination,

Preprints | 2022

DiNardi R; Douglas AO; Tian R; Price J; Tajik M; Donald WA; Beves J, 2022, Visible-light-responsive self-assembled complexes: improved photoswitching properties by metal ion coordination, ,

Preprints | 2022

DiNardi R; Douglas AO; Tian R; Price J; Tajik M; Donald WA; Beves J, 2022, Visible-light-responsive self-assembled complexes: improved photoswitching properties by metal ion coordination, ,

Preprints | 2022

DiNardi R; Douglas AO; Tian R; Price J; Tajik M; Donald WA; Beves J, 2022, Visible-light-responsive self-assembled complexes: improved photoswitching properties by metal ion coordination, ,

Preprints | 2022

Mastellone J; Kabir KMM; Huang X; Donald W, 2022, Separation of disaccharide epimers, anomers and connectivity isomers by high resolution differential ion mobility mass spectrometry,

Preprints | 2022

Mastellone J; Kabir KMM; Huang X; Donald W, 2022, Separation of disaccharide epimers, anomers and connectivity isomers by high resolution differential ion mobility mass spectrometry, ,

Preprints | 2022

Mastellone J; Kabir KMM; Huang X; Donald W, 2022, Separation of disaccharide epimers, anomers and connectivity isomers by high resolution differential ion mobility mass spectrometry, ,

Preprints | 2022

Zhang JD; Xue C; Kolachalama VB; Donald WA, 2022, Interpretable machine learning on metabolomics data reveals biomarkers for Parkinson’s disease,

Preprints | 2021

Kennedy A; DiNardi R; Fillbrook L; Donald W; Beves J, 2021, Visible light switching of metallosupramolecular assemblies, ,

Preprints | 2021

Mastellone J; Kabir KMM; Donald W, 2021, Separation of disaccharide epimers, anomers and connectivity isomers by high resolution differential ion mobility mass spectrometry, ,

Preprints | 2021

Mastellone J; Kabir KMM; Donald W, 2021, Separation of disaccharide epimers, anomers and connectivity isomers by high resolution differential ion mobility mass spectrometry, ,

Preprints | 2021

Nguyen G; Bennett J; Liu S; Hancock S; Winter D; Glover D; Donald W, 2021, Multiplexed screening of thousands of natural products for protein-ligand binding in native mass spectrometry,

Preprints | 2021

Nguyen G; Bennett J; Liu S; Hancock S; Winter D; Glover D; Donald W, 2021, Multiplexed screening of thousands of natural products for protein-ligand binding in native mass spectrometry,

Preprints | 2021

Nguyen G; Bennett J; Liu S; Hancock S; Winter D; Glover D; Donald W, 2021, Multiplexed screening of thousands of natural products for protein-ligand binding in native mass spectrometry,

Preprints | 2021

Nguyen G; Bennett J; Liu S; Hancock S; Winter D; Glover D; Donald W, 2021, Multiplexed screening of thousands of natural products for protein-ligand binding in native mass spectrometry, ,

Preprints | 2020

Chen X; Ching K; Rawal A; Lawes D; Tajiki M; Donald W; Lee SH; Ruoff R, 2020, Stage-1 Cationic C60 Intercalated Graphene Oxide Films,

Preprints | 2020

Chen X; Ching K; Rawal A; Lawes D; Tajiki M; Donald W; Lee SH; Ruoff R, 2020, Stage-1 Cationic C60 Intercalated Graphene Oxide Films,

WA Donald,��Cracking post-translational modification codes in high molecular definition; ARC Future Fellowship; 2020-2023

AJ Trevitt, WA Donald, C Jouvet;��New laser and mass spectrometry methods for detecting protonation isomers; ARC Discovery Projects; 2020-2022

WA Donald, CT Supuran; Ultrasensitive chemical analysis of single cells by mass spectrometry; ARC Discovery Project; 2019-2021

WA Donald, CT Supuran; Rapid, Ultra-sensitive Protein Structure Elucidation by Mass Spectrometry; ARC Discovery Project; 2016-2018

Mass spectrometry is a core enabling technology that is used in many emerging and existing scientific fields.�� We are developing and applying experimental methods in mass spectrometry with an emphasis on fundamental and applied problems in chemistry and biochemistry.

Our current objectives are to:

Significantly improve the rapid detection of organic molecules, biomarkers, and proteins with ultrahigh sensitivity by use of advanced ionization, ion mobility and tandem mass spectrometry methods
Understand the molecular origins of cellular heterogeneity by developing novel single cell mass spectrometry methodologies
Develop high-performance, portable ion spectrometers that operate at ambient pressure for the detection of many different chemicals nearly simultaneously
Discover and explore the mechanisms of chemical reactions that are mediated by transition metal complexes and catalysts using ion-molecule reactions, ion fragmentation methods, and ion spectroscopy

Our research is highly interdisciplinary and we actively collaborate with other researchers in pharmacology & medicinal chemistry, protein engineering, bioinorganic chemistry, molecular biology, surface & materials chemistry, and electrical engineering.��

Selected Publications

1. Nguyen, G. T. H.; Tran, T. N.; Podgorski, M. N.; Bell, S. G.; Supuran, C. T.; Donald, W. A. Nanoscale ion emitters in native mass spectrometry for measuring ligand-protein binding affinities.��ACS Central Science, 2019, 5, 308-318.

2. Winter, D. L.; Wilkins, M. R.; Donald, W. A. Differential ion mobility-mass spectrometry for detailed analysis of the proteome.��Trends in Biotechnology, 2019, 37, 198-213.

3. Zenaidee, M. A.; Leeming, M. G.; Zhang, F.; Funston, T. T.; Donald, W. A. Highly charged protein ions: The strongest organic acids to date.��Angewandte Chemie International Edition, 2017, 56, 8522-26 ("Very Important Paper").

4. Kabir, K. M. M.; Donald, W. A. Microscale differential ion mobility spectrometry for field deployable chemical analysis.��Trends in Analytical Chemistry, 2017, 97, 399-427.

5. Dumlao, M. C.; Xiao, D.; Zhang, D.; Fletcher, J.; Donald, W. A. Effects of different waveforms on the performance of active capillary dielectric barrier discharge ionization mass spectrometry.��Journal of the American Society for Mass Spectrometry, 2017, 28, 575-78 (Cover of Emerging Investigator Issue).

6. Leeming, M. G.; Donald, W. A.; O'Hair, R. A. J. Non-targeted identification of reactive metabolite protein adducts.��Analytical Chemistry, 2017, 89, 5748-56.

7.��Dumlao, M. C.; Jeffress, L. E.; Gooding, J. J.; Donald, W. A. Solid-phase microextraction low temperature plasma mass spectrometry for the direct and rapid analysis of chemical warfare simulants in complex mixtures.��Analyst, 2016, 141, 3714-21��(Emerging Investigator Issue).

8. Leeming, M. G.; Isaac, A. P.; Pope, B. J.; Cranswick, N.; Wright, C. E.; Ziogas, J.; O'Hair, R. A. J.; Donald, W. A. High-Resolution Twin-Ion Metabolite Extraction (HiTIME) Mass Spectrometry: Nontargeted Detection of Unknown Drug Metabolites by Isotope Labeling, Liquid Chromatography Mass Spectrometry, and Automated High-Performance Computing.��Analytical Chemistry, 2015,��87, 4104-09.

9. Zenaidee, M. A.; Donald, W. A.��Electron capture dissociation of extremely supercharged protein ions formed by electrospray ionisation.��Analytical Methods, 2015,��7, 7132 (Emerging Investigator Issue).

10.��Teo, C. A.; Donald, W. A. Solution Additives for Supercharging Proteins Beyond the Theoretical Maximum Proton-Transfer Limit in Electrospray Ionization Mass Spectrometry.��Analytical Chemistry, 2014,��86, 4455-62.

Editorial Activities:

Book editor, Advances in ion-mobility mass spectrometry: Fundamentals, instrumentation, and applications (Comprehensive Analytical Chemistry, Vol. 83; Elsevier, 2019)

Associate Editor (Handling Editor), Journal of Enzyme Inhibition and Medicinal Chemistry��(2019-��ܰ��Գ�)

Editorial Board, International Journal of Molecular Sciences��(2018-��ܰ��Գ�)

Editorial Board, Expert Opinion on Therapeutic Patents��(2017-��ܰ��Գ�)

Editorial Board, Journal of Enzyme Inhibition and Medicinal Chemistry��(2017-��ܰ��Գ�)

��

Professional Roles:

Vice president, Australian & New Zealand Society for Mass Spectrometry (2020-current)

Past chair,��Royal Australian Chemical Institute NSW Analytical and Environmental Chemistry Group (2020-current)

Treasurer, Australian & New Zealand Society for Mass Spectrometry (2016-2020)

Chair, Royal Australian Chemical Institute NSW Analytical and Environmental Chemistry Group (2017-2020)

Chair-elect, Royal Australian Chemical Institute NSW Analytical and Environmental Chemistry Group (2015-17)

Management committee, NSW Smart Sensing Network (2016-17)

��

My Research Supervision

Current group

Research Fellows and Postdocs:

Dr. K. M. Mohibul Kabir (DECRA Fellow; close collaborator)

Dr. Morphy Dumlao (with National Wine and Grape Industry Centre)

Dr. Giang Nguyen

PhD Students:

Ezaz Ahmed

Susannah Brown

Hyun Eui (Peter) Lee

Diana Zhang��

Phuong (Chi) Pham

Merryn Baker��

Suhyeon (Renee) Kwon

Alireza Mashouf

Mohammad Tajiki

Xiaojing Huang��

Masters-by-Research Student:

Qinwen Liu

Honours Students:

Jack Bennett��

Olivia Rusli

Anthony Tran (with Dr Mohibul Kabir)

��

Group Alumni

Postdoc, PhD and Masters:

Fon Kankaew (MSc graduate, 2020)

Liang Jiang (MSc graduate, 2020)

Giang Nguyen (PhD graduate, 2020)

Huixin Wang (PhD graduate, 2019)

Jordan Mastellone (MPhil graduate, 2019)

Muhammad A. Zenaidee (PhD graduate, 2019)

Panthipa Suwannakot (MSc graduate, 2019)

Peter Lee (MSc graduate, 2017)

Morphy Dumlao (PhD graduate, 2017)

Toby Mills (PhD graduate, 2017)

Dr. Fangtong Zhang (Postdoctoral research fellow, 2013-2015)

Honours:

Sherrie Liu (Honours student, 2019-2020)

Merryn Baker (Honours student, 2018)

Vickie Chan (Honours student, 2018)

Diana Zhang (Undergraduate student, 2016; Honours student, 2017)

Eric Foley (Undergraduate student, 2016; University medal for honours performance, 2017)

Susannah Brown (Undergraduate student, 2015; University medal for honours performance, 2016)

Chung Hong Chan (2016)

Laura Jeffress (2015)

Grace Yong (Undergraduate student, 2015; Honours student, 2015)

Edward Stephens (2015)

Sunny Xiong (2014)

Muhammad A. Zenaidee (2014)

Edward Jiang (2013)

Ann Teo (2013)

Lab Alumni (Undergraduate students)

Manatsu Nose (2020)

Monika Vesse (2020)

Sherrie Liu (2019)

Daniel Loo (2019)

Joe Harding (2018)

Denise de Meijer (2018, visiting praticum exchange student from Saxion University, Deventer, Netherlands)

Surabhi Naik (2016)

Natalie Coulton (2016)

Mohammed Al-Farsi (2015)

Toby Funston (2015)

Precilia Hermanto (2015)

MacKenzie Hagan (2014)

��

My Teaching

Course Coordinator and Lecturer, Analytical Chemistry: Essential Methods (Second Year Level, Terms 1 and 3)

Lecturer, Chemistry 1A (First Year Level, Term 3)

��

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