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Dr Paul Timpson

Conjoint Professor
Medicine & Health
School of Clinical Medicine
Phone
93558521
  • Book Chapters | 2009
    Bennett HL; Brummer T; Timpson P; Patterson K; Daly RJ, 2009, 'Signalling by the EGF receptor in human cancers: Accentuate the positive, eliminate the negative.', in Haley JD; Gullick WJ (ed.), Cancer Drug Discovery and Development: EGFR Signaling Networks in Cancer Therapy, Humana Press, pp. 224 - 244,
  • Journal articles | 2024
    Filipe EC; Velayuthar S; Philp A; Nobis M; Latham SL; Parker AL; Murphy KJ; Wyllie K; Major GS; Contreras O; Mok ETY; Enriquez RF; McGowan S; Feher K; Quek LE; Hancock SE; Yam M; Tran E; Setargew YFI; Skhinas JN; Chitty JL; Phimmachanh M; Han JZR; Cadell AL; Papanicolaou M; Mahmodi H; Kiedik B; Junankar S; Ross SE; Lam N; Coulson R; Yang J; Zaratzian A; Da Silva AM; Tayao M; Chin IL; Cazet A; Kansara M; Segara D; Parker A; Hoy AJ; Harvey RP; Bogdanovic O; Timpson P; Croucher DR; Lim E; Swarbrick A; Holst J; Turner N; Choi YS; Kabakova IV; Philp A; Cox TR, 2024, 'Tumor Biomechanics Alters Metastatic Dissemination of Triple Negative Breast Cancer via Rewiring Fatty Acid Metabolism', Advanced Science, 11,
    Journal articles | 2024
    Ju RJ; Falconer AD; Schmidt CJ; Enriquez Martinez MA; Dean KM; Fiolka RP; Sester DP; Nobis M; Timpson P; Lomakin AJ; Danuser G; White MD; Haass NK; Oelz DB; Stehbens SJ, 2024, 'Compression-dependent microtubule reinforcement enables cells to navigate confined environments', Nature Cell Biology,
    Journal articles | 2024
    Pereira BA; Ritchie S; Chambers CR; Gordon KA; Magenau A; Murphy KJ; Nobis M; Tyma VM; Liew YF; Lucas MC; Naeini MM; Barkauskas DS; Chacon-Fajardo D; Howell AE; Parker AL; Warren SC; Reed DA; Lee V; Metcalf XL; Lee YK; O'Regan LP; Zhu J; Trpceski M; Fontaine ARM; Stoehr J; Rouet R; Lin X; Chitty JL; Porazinski S; Wu SZ; Filipe EC; Cadell AL; Holliday H; Yang J; Papanicolaou M; Lyons RJ; Zaratzian A; Tayao M; Da Silva A; Vennin C; Yin J; Dew AB; McMillan PJ; Goldstein LD; Deveson IW; Croucher DR; Samuel MS; Sim HW; Batten M; Chantrill L; Grimmond SM; Gill AJ; Samra J; Jeffry Evans TR; Sasaki T; Phan TG; Swarbrick A; Sansom OJ; Morton JP; Pajic M; Parker BL; Herrmann D; Cox TR; Timpson P, 2024, 'Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response', Science Advances, 10,
    Journal articles | 2024
    Pitiyarachchi O; Lin FP; Spooner A; Sharbeen G; Barker HP; Thornton K; Collignon E; Ballinger ML; Thomas DM; Magenau A; Porazinski S; Raina A; Sjoquist KM; Chantrill LA; Gebski V; Sowmya A; Timpson P; Pajic M; Goldstein D; Phillips PA, 2024, '1513P Impact of symptom and functional burden on survival in pancreatic ductal adenocarcinoma (PDAC)', Annals of Oncology, 35, pp. S925 - S925,
    Journal articles | 2024
    Sugiyama Y; Reed DA; Herrmann D; Lovicu FJ; Robinson ML; Timpson P; Masai I, 2024, 'Fibroblast growth factor-induced lens fiber cell elongation is driven by the stepwise activity of Rho and Rac', Development (Cambridge), 151, pp. 1 - 9,
    Journal articles | 2024
    Timpson P; Pereira B; Ritchie S; katie Gordon ; Cox T, 2024, 'Abstract PR-09: Temporally resolved proteomics identifies nidogen-2 as a co-target in pancreatic cancer that modulates fibrosis and therapy response', Cancer Research, 84,
    Journal articles | 2024
    Tyma V; Liew Y-F; Tran A; Howell A; Ritchie S; Pancreatic Cancer Matrix Atlas AA; Genome Initiative AP; Cox T; Pajic M; Herrmann D; Pereira B; Timpson P; Gordon K, 2024, 'Abstract A067: Identifying and targeting FOLFIRINOX resistance mechanisms to improve outcomes in pancreatic cancer', Cancer Research, 84, pp. A067 - A067,
    Journal articles | 2023
    Bhattacharyya ND; Kyaw W; McDonald MM; Dhenni R; Grootveld AK; Xiao Y; Chai R; Khoo WH; Danserau LC; Sergio CM; Timpson P; Lee WM; Croucher PI; Phan TG, 2023, 'Minimally invasive longitudinal intravital imaging of cellular dynamics in intact long bone', Nature Protocols, 18, pp. 3856 - 3880,
    Journal articles | 2023
    Boslem E; Reibe S; Carlessi R; Smeuninx B; Tegegne S; Egan CL; McLennan E; Terry LV; Nobis M; Mu A; Nowell C; Horadagoda N; Mellett NA; Timpson P; Jones M; Denisenko E; Forrest ARR; Tirnitz-Parker JEE; Meikle PJ; Rose-John S; Karin M; Febbraio MA, 2023, 'Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC', Science Advances, 9,
    Journal articles | 2023
    Burns C; Murphy K; Cock T-A; Devlin M; Herrmann D; Timpson P, 2023, 'The effect of adding a selective FAK inhibitor AMP945 to FOLFIRINOX in a model of pancreatic cancer.', Journal of Clinical Oncology, 41, pp. e15128 - e15128,
    Journal articles | 2023
    Chitty JL; Yam M; Perryman L; Parker AL; Skhinas JN; Setargew YFI; Mok ETY; Tran E; Grant RD; Latham SL; Pereira BA; Ritchie SC; Murphy KJ; Trpceski M; Findlay AD; Melenec P; Filipe EC; Nadalini A; Velayuthar S; Major G; Wyllie K; Papanicolaou M; Ratnaseelan S; Phillips PA; Sharbeen G; Youkhana J; Russo A; Blackwell A; Hastings JF; Lucas MC; Chambers CR; Reed DA; Stoehr J; Vennin C; Pidsley R; Zaratzian A; Da Silva AM; Tayao M; Charlton B; Herrmann D; Nobis M; Clark SJ; Biankin AV; Johns AL; Croucher DR; Nagrial A; Gill AJ; Grimmond SM; Chantrill LA; Chou A; Dwarte T; Metcalf XL; Jeong G; Kenyon L; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Hofmann O; Samra JS; Pavlakis N; Arena J; High HA; Asghari R; Merrett ND; Das A; Cosman PH; Ismail K; Stoita A; Williams D; Spigellman A; McLeo D; Kirk J; Kench JG; Grimison P; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forrest C; Ballal M; Fletcher D; Beilin M; Feeney K; Epari K; Mukhedkar S; Zeps N; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J, 2023, 'A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer', Nature Cancer, 4, pp. 1326 - 1344,
    Journal articles | 2023
    Conway JRW; Warren SC; Lee YK; McCulloch AT; Magenau A; Lee V; Metcalf XL; Stoehr J; Haigh K; Abdulkhalek L; Guaman CS; Reed DA; Murphy KJ; Pereira BA; Mélénec P; Chambers C; Latham SL; Lenthall H; Deenick EK; Ma Y; Phan T; Lim E; Joshua AM; Walters S; Grey ST; Shi YC; Zhang L; Herzog H; Croucher DR; Philp A; Scheele CLGJ; Herrmann D; Sansom OJ; Morton JP; Papa A; Haigh JJ; Nobis M; Timpson P, 2023, 'Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse', Science Advances, 9,
    Journal articles | 2023
    Hastings JF; Latham SL; Kamili A; Wheatley MS; Han JZR; Wong-Erasmus M; Phimmachanh M; Nobis M; Pantarelli C; Cadell AL; O’Donnell YEI; Leong KH; Lynn S; Geng FS; Cui L; Yan S; Achinger-Kawecka J; Stirzaker C; Norris MD; Haber M; Trahair TN; Speleman F; De Preter K; Cowley MJ; Bogdanovic O; Timpson P; Cox TR; Kolch W; Fletcher JI; Fey D; Croucher DR, 2023, 'Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma', Science Advances, 9,
    Journal articles | 2023
    Sugiyama Y; Reed DA; Herrmann D; Lovicu FJ; Robinson ML; Timpson P; Masai I, 2023, 'Fibroblast Growth Factor-induced lens fiber cell elongation is driven by the stepwise activity of Rho and Rac.', bioRxiv,
    Journal articles | 2023
    Uceda-Castro R; Margarido AS; Song JY; de Gooijer MC; Messal HA; Chambers CR; Nobis M; Çitirikkaya CH; Hahn K; Seinstra D; Herrmann D; Timpson P; Wesseling P; van Tellingen O; Vennin C; van Rheenen J, 2023, 'BCRP drives intrinsic chemoresistance in chemotherapy-naïve breast cancer brain metastasis', Science Advances, 9,
    Journal articles | 2022
    Dawson JC; Munro A; Macleod K; Muir M; Timpson P; Williams RJ; Frame M; Brunton VG; Carragher NO, 2022, 'Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors for cancer treatment', Molecular Oncology, 16, pp. 1072 - 1090,
    Journal articles | 2022
    Dreyer SB; Upstill-Goddard R; Legrini A; Biankin AV; Allison S; Beraldi D; Cameron E; Chang DK; Cooke SL; Cunningham R; Grimwood P; Kelly S; Marshall J; McDade B; Musgrove EA; Ramsay D; Evers L; Rebus S; Rahib L; Serrels B; Jamieson NB; McKay CJ; Westwood P; Williams N; Duthie F; Shen W; Pea A; Johns AL; Gill AJ; Chantrill LA; Timpson P; Chou A; Pajic M; Dwarte T; Herrmann D; Vennin C; Cox TR; Pereira B; Ritchiee S; Reed DA; Chambers CR; Metcalf X; Nobis M; Jeong G; Kenyon L; Lyons RJ; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Grimmond SM; Hofmann O; Samra JS; Pavlakis N; Arena J; High HA; Asghari R; Merrett ND; Das A; Cosman PH; Ismail K; Stoita A; Williams D; Spigellman A; McLeod D; Kirk J; Kench JG; Grimison P; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forrest C; Ballal M; Fletcher D; Beilin M; Feeney K; Epari K; Mukhedkar S; Zeps N; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O'Rourke TJ; Fawcett JW, 2022, 'Genomic and Molecular Analyses Identify Molecular Subtypes of Pancreatic Cancer Recurrence', Gastroenterology, 162, pp. 320 - 324.e4,
    Journal articles | 2022
    Jose J; Hoque M; Engel J; Beevi SS; Wahba M; Georgieva MI; Murphy KJ; Hughes WE; Cochran BJ; Lu A; Tebar F; Hoy AJ; Timpson P; Rye KA; Enrich C; Rentero C; Grewal T, 2022, 'Annexin A6 and NPC1 regulate LDL-inducible cell migration and distribution of focal adhesions', Scientific Reports, 12,
    Journal articles | 2022
    Meagher NS; Gorringe KL; Wakefield M; Bolithon A; Pang CNI; Chiu DS; Anglesio MS; Mallitt KA; Doherty JA; Harris HR; Schildkraut JM; Berchuck A; Cushing-Haugen KL; Chezar K; Chou A; Tan A; Alsop J; Barlow E; Beckmann MW; Boros J; Bowtell DDL; Brand AH; Brenton JD; Campbell I; Cheasley D; Cohen J; Cybulski C; Elishaev E; Erber R; Farrell R; Fischer A; Fu Z; Gilks B; Gill AJ; Gourley C; Grube M; Harnett PR; Hartmann A; Hettiaratchi A; Høgdall CK; Huzarski T; Jakubowska A; Jimenez-Linan M; Kennedy CJ; Kim BG; Kim JW; Kim JH; Klett K; Koziak JM; Lai T; Laslavic A; Lester J; Leung Y; Li N; Liauw W; Lim BWX; Linder A; Lubinski J; Mahale S; Mateoiu C; McInerny S; Menkiszak J; Minoo P; Mittelstadt S; Morris D; Orsulic S; Park SY; Pearce CL; Pearson JV; Pike MC; Quinn CM; Mohan GR; Rao J; Riggan MJ; Ruebner M; Salfinger S; Scott CL; Shah M; Steed H; Stewart CJR; Subramanian D; Sung S; Tang K; Timpson P; Ward RL; Wiedenhoefer R; Thorne H; Cohen PA; Crowe P; Fasching PA; Gronwald J; Hawkins NJ; Høgdall E; Huntsman DG; James PA; Karlan BY; Kelemen LE; Kommoss S; Konecny GE; Modugno F, 2022, 'Gene-Expression Profiling of Mucinous Ovarian Tumors and Comparison with Upper and Lower Gastrointestinal Tumors Identifies Markers Associated with Adverse Outcomes', Clinical Cancer Research, 28, pp. 5383 - 5395,
    Journal articles | 2022
    Murphy KJ; Reed DA; Chambers CR; Zhu J; Magenau A; Pereira BA; Timpson P; Herrmann D, 2022, 'Cell-derived Matrix Assays to Assess Extracellular Matrix Architecture and Track Cell Movement', Bio-protocol, 12,
    Journal articles | 2022
    Murphy KJ; Zhu J; Trpceski M; Pereira BA; Timpson P; Herrmann D, 2022, 'Focal adhesion kinase priming in pancreatic cancer, altering biomechanics to improve chemotherapy', Biochemical Society Transactions, 50, pp. 1129 - 1141,
    Journal articles | 2022
    Papanicolaou M; Parker AL; Yam M; Filipe EC; Wu SZ; Chitty JL; Wyllie K; Tran E; Mok E; Nadalini A; Skhinas JN; Lucas MC; Herrmann D; Nobis M; Pereira BA; Law AMK; Castillo L; Murphy KJ; Zaratzian A; Hastings JF; Croucher DR; Lim E; Oliver BG; Mora FV; Parker BL; Gallego-Ortega D; Swarbrick A; O’Toole S; Timpson P; Cox TR, 2022, 'Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis', Nature Communications, 13,
    Journal articles | 2022
    Scheele CLGJ; Herrmann D; Yamashita E; Lo Celso C; Jenne CN; Oktay MH; Entenberg D; Friedl P; Weigert R; Meijboom FLB; Ishii M; Timpson P; van Rheenen J, 2022, 'Multiphoton intravital microscopy of rodents', Nature Reviews Methods Primers, 2,
    Journal articles | 2021
    Chambers CR; Ritchie S; Pereira BA; Timpson P, 2021, 'Overcoming the senescence-associated secretory phenotype (SASP): a complex mechanism of resistance in the treatment of cancer', Molecular Oncology, 15, pp. 3242 - 3255,
    Journal articles | 2021
    Cinco R; Dragan M; Gratton E; Welch H; Timpson P; Dai X; Digman MA, 2021, 'Spatiotemporal Dynamics of RAC1 Signaling During Wound Healing in Forster Resonance Energy Transfer Biosensor Mice', Biophysical Journal, 120, pp. 105a - 105a,
    Journal articles | 2021
    Floerchinger A; Murphy KJ; Latham SL; Warren SC; McCulloch AT; Lee YK; Stoehr J; Mélénec P; Guaman CS; Metcalf XL; Lee V; Zaratzian A; Da Silva A; Tayao M; Rolo S; Phimmachanh M; Sultani G; McDonald L; Mason SM; Ferrari N; Ooms LM; Johnsson AKE; Spence HJ; Olson MF; Machesky LM; Sansom OJ; Morton JP; Mitchell CA; Samuel MS; Croucher DR; Welch HCE; Blyth K; Caldon CE; Herrmann D; Anderson KI; Timpson P; Nobis M, 2021, 'Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging', Cell Reports, 36,
    Journal articles | 2021
    Ghoroghi S; Mary B; Larnicol A; Asokan N; Klein A; Osmani N; Busnelli I; Delalande F; Paul N; Halary S; Gros F; Fouillen L; Haeberle AM; Royer C; Spiegelhalter C; André-Grégoire G; Mittelheisser V; Detappe A; Murphy K; Timpson P; Carapito R; Blot-Chabaud M; Gavard J; Carapito C; Vitale N; Lefebvre O; Goetz JG; Hyenne V, 2021, 'Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes', eLife, 10, pp. 1 - 29,
    Journal articles | 2021
    Guo G; Papanicolaou M; Demarais NJ; Wang Z; Schey KL; Timpson P; Cox TR; Grey AC, 2021, 'Automated annotation and visualisation of high-resolution spatial proteomic mass spectrometry imaging data using HIT-MAP', Nature Communications, 12,
    Journal articles | 2021
    Kokkinos J; Sharbeen G; Haghighi KS; Ignacio RMC; Kopecky C; Gonzales-Aloy E; Youkhana J; Timpson P; Pereira BA; Ritchie S; Pandzic E; Boyer C; Davis TP; Butler LM; Goldstein D; McCarroll JA; Phillips PA, 2021, 'Ex vivo culture of intact human patient derived pancreatic tumour tissue', Scientific Reports, 11, pp. 1944,
    Journal articles | 2021
    Lakis V; Lawlor RT; Newell F; Patch AM; Mafficini A; Sadanandam A; Koufariotis LT; Johnston RL; Leonard C; Wood S; Rusev B; Corbo V; Luchini C; Cingarlini S; Landoni L; Salvia R; Milella M; Chang D; Bailey P; Jamieson NB; Duthie F; Gingras MC; Muzny DM; Wheeler DA; Gibbs RA; Milione M; Chantrill LA; Timpson P; Chou A; Pajic M; Murphy A; Dwarte T; Hermann D; Vennin C; Cox TR; Pereira B; Ritchie S; Reed DA; Chambers CR; Metcalf X; Nobis M; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Xu Q; Hofmann O; Samra JS; Pavlakis N; Arena J; High HA; Asghari R; Merrett ND; Pavey D; Das A; Cosman PH; Ismail K; O’Connnor C; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forest C; Ballal M; Fletcher DR; Zeps N; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Dixon J; Scardoni M; Bassi C; Grimaldi S; Cantù C; Bonizzato G; Bersani S; Biankin A; Johns A; Herrmann D, 2021, 'DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association', Communications Biology, 4, pp. 155,
    Journal articles | 2021
    Liu D; Sharbeen G; Phillips P; Johns AL; Gill AJ; Chantrill LA; Timpson P; Chou A; Pajic M; Dwarte T; Herrmann D; Vennin C; Cox TR; Pereira B; Ritchie S; Reed DA; Chambers CR; Metcalf X; Nobis M; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Grimmond SM; Hofmann O; Samra JS; Pavlakis N; Arena J; High HA; Asghari R; Merrett ND; Das A; Cosman PH; Ismail K; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forrest C; Ballal M; Fletcher D; Beilin M; Feeney K; Epari K; Mukhedkar S; Zeps N; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Scarpa A; Lawlor RT; Corbo V; Bassi C; Biankin AV; Jamieson NB; Chang DK; Dreyer SB; Ford CE, 2021, 'ROR1 and ROR2 expression in pancreatic cancer', BMC Cancer, 21,
    Journal articles | 2021
    McDonald MM; Khoo WH; Ng PY; Xiao Y; Zamerli J; Thatcher P; Kyaw W; Pathmanandavel K; Grootveld AK; Moran I; Butt D; Nguyen A; Corr A; Warren S; Biro M; Butterfield NC; Guilfoyle SE; Komla-Ebri D; Dack MRG; Dewhurst HF; Logan JG; Li Y; Mohanty ST; Byrne N; Terry RL; Simic MK; Chai R; Quinn JMW; Youlten SE; Pettitt JA; Abi-Hanna D; Jain R; Weninger W; Lundberg M; Sun S; Ebetino FH; Timpson P; Lee WM; Baldock PA; Rogers MJ; Brink R; Williams GR; Bassett JHD; Kemp JP; Pavlos NJ; Croucher PI; Phan TG, 2021, 'Erratum: Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption (Cell (2021) 184(5) (1330–1347.e13), (S0092867421001525), (10.1016/j.cell.2021.02.002))', Cell, 184, pp. 1940,
    Journal articles | 2021
    McDonald MM; Khoo WH; Ng PY; Xiao Y; Zamerli J; Thatcher P; Kyaw W; Pathmanandavel K; Grootveld AK; Moran I; Butt D; Nguyen A; Warren S; Biro M; Butterfield NC; Guilfoyle SE; Komla-Ebri D; Dack MRG; Dewhurst HF; Logan JG; Li Y; Mohanty ST; Byrne N; Terry RL; Simic MK; Chai R; Quinn JMW; Youlten SE; Pettitt JA; Abi-Hanna D; Jain R; Weninger W; Lundberg M; Sun S; Ebetino FH; Timpson P; Lee WM; Baldock PA; Rogers MJ; Brink R; Williams GR; Bassett JHD; Kemp JP; Pavlos NJ; Croucher PI; Phan TG; Corr A, 2021, 'Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption', Cell, 184, pp. 1330 - 1347.e13,
    Journal articles | 2021
    Murphy KJ; Chambers CR; Herrmann D; Timpson P; Pereira BA, 2021, 'Dynamic stromal alterations influence tumor-stroma crosstalk to promote pancreatic cancer and treatment resistance', Cancers, 13,
    Journal articles | 2021
    Murphy KJ; Reed DA; Trpceski M; Herrmann D; Timpson P, 2021, 'Quantifying and visualising the nuances of cellular dynamics in vivo using intravital imaging', Current Opinion in Cell Biology, 72, pp. 41 - 53,
    Journal articles | 2021
    Murphy KJ; Reed DA; Vennin C; Conway JRW; Nobis M; Yin JX; Chambers CR; Pereira BA; Lee V; Filipe EC; Trpceski M; Ritchie S; Lucas MC; Warren SC; Skhinas JN; Magenau A; Metcalf XL; Stoehr J; Major G; Parkin A; Bidanel R; Lyons RJ; Zaratzian A; Tayao M; Da Silva A; Abdulkhalek L; Gill AJ; Johns AL; Biankin AV; Samra J; Grimmond SM; Chou A; Goetz JG; Samuel MS; Lyons JG; Burgess A; Caldon CE; Horvath LG; Daly RJ; Gadegaard N; Wang Y; Sansom OJ; Morton JP; Cox TR; Pajic M; Herrmann D; Timpson P, 2021, 'Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status', Science Advances, 7,
    Journal articles | 2021
    Nemec S; Lam J; Zhong J; Heu C; Timpson P; Li Q; Youkhana J; Sharbeen G; Phillips PA; Kilian KA, 2021, 'Cancer‐Associated Fibroblasts: Interfacial Curvature in Confined Coculture Directs Stromal Cell Activity with Spatial Corralling of Pancreatic Cancer Cells (Adv. Biology 6/2021)', Advanced Biology, 5,
    Journal articles | 2021
    Nemec S; Lam J; Zhong J; Heu C; Timpson P; Li Q; Youkhana J; Sharbeen G; Phillips PA; Kilian KA, 2021, 'Interfacial Curvature in Confined Coculture Directs Stromal Cell Activity with Spatial Corralling of Pancreatic Cancer Cells', Advanced Biology, 5, pp. e2000525,
    Journal articles | 2021
    Pal B; Chen Y; Milevskiy MJG; Vaillant F; Prokopuk L; Dawson CA; Capaldo BD; Song X; Jackling F; Timpson P; Lindeman GJ; Smyth GK; Visvader JE, 2021, 'Single cell transcriptome atlas of mouse mammary epithelial cells across development', Breast Cancer Research, 23,
    Journal articles | 2021
    Rajal AG; Marzec KA; McCloy RA; Nobis M; Chin V; Hastings JF; Lai K; Kennerson M; Hughes WE; Vaghjiani V; Timpson P; Cain JE; Watkins DN; Croucher DR; Burgess A, 2021, 'A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma', eLife, 10,
    Journal articles | 2021
    Ritchie S; Reed DA; Pereira BA; Timpson P, 2021, 'The cancer cell secretome drives cooperative manipulation of the tumour microenvironment to accelerate tumourigenesis.', Fac Rev, 10, pp. 4,
    Journal articles | 2021
    Samuel M; Fonseka P; Sanwlani R; Gangoda L; Chee SH; Keerthikumar S; Spurling A; Chitti SV; Zanker D; Ang CS; Atukorala I; Kang T; Shahi S; Marzan AL; Nedeva C; Vennin C; Lucas MC; Cheng L; Herrmann D; Pathan M; Chisanga D; Warren SC; Zhao K; Abraham N; Anand S; Boukouris S; Adda CG; Jiang L; Shekhar TM; Baschuk N; Hawkins CJ; Johnston AJ; Orian JM; Hoogenraad NJ; Poon IK; Hill AF; Jois M; Timpson P; Parker BS; Mathivanan S, 2021, 'Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis', Nature Communications, 12,
    Journal articles | 2021
    Sharbeen G; McCarroll JA; Akerman A; Kopecky C; Youkhana J; Kokkinos J; Holst J; Boyer C; Erkan M; Goldstein D; Timpson P; Cox TR; Pereira BA; Chitty JL; Fey SK; Najumudeen AK; Campbell AD; Sansom OJ; Ignacio RMC; Naim S; Liu J; Russia N; Lee J; Chou A; Johns A; Gill AJ; Gonzales-Aloy E; Gebski V; Guan YF; Pajic M; Turner N; Apte MV; Davis TP; Morton JP; Haghighi KS; Kasparian J; McLean BJ; Setargew YF; Phillips PA, 2021, 'Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to slc7a11 inhibition', Cancer Research, 81, pp. 3461 - 3479,
    Journal articles | 2021
    Valdés-Mora F; Salomon R; Gloss BS; Law AMK; Venhuizen J; Castillo L; Murphy KJ; Magenau A; Papanicolaou M; Rodriguez de la Fuente L; Roden DL; Colino-Sanguino Y; Kikhtyak Z; Farbehi N; Conway JRW; Sikta N; Oakes SR; Cox TR; O'Donoghue SI; Timpson P; Ormandy CJ; Gallego-Ortega D, 2021, 'Single-cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype', Cell Reports, 35,
    Journal articles | 2021
    Yan C; Zeng T; Lee K; Nobis M; Loh K; Gou L; Xia Z; Gao Z; Bensellam M; Hughes W; Lau J; Zhang L; Ip CK; Enriquez R; Gao H; Wang QP; Wu Q; Haigh JJ; Laybutt DR; Timpson P; Herzog H; Shi YC, 2021, 'Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity', Nature Communications, 12,
    Journal articles | 2020
    Boyle ST; Kular J; Nobis M; Ruszkiewicz A; Timpson P; Samuel MS, 2020, 'Acute compressive stress activates RHO/ROCK-mediated cellular processes', Small GTPases, 11, pp. 354 - 370,
    Journal articles | 2020
    Boyle ST; Poltavets V; Kular J; Pyne NT; Sandow JJ; Lewis AC; Murphy KJ; Kolesnikoff N; Moretti PAB; Tea MN; Tergaonkar V; Timpson P; Pitson SM; Webb AI; Whitfield RJ; Lopez AF; Kochetkova M; Samuel MS, 2020, 'Publisher Correction: ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism (Nature Cell Biology, (2020), 22, 7, (882-895), 10.1038/s41556-020-0523-y)', Nature Cell Biology, 22, pp. 908,
    Journal articles | 2020
    Boyle ST; Poltavets V; Kular J; Pyne NT; Sandow JJ; Lewis AC; Murphy KJ; Kolesnikoff N; Moretti PAB; Tea MN; Tergaonkar V; Timpson P; Pitson SM; Webb AI; Whitfield RJ; Lopez AF; Kochetkova M; Samuel MS, 2020, 'ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism', Nature Cell Biology, 22, pp. 882 - 895,
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    Castillo L; Young AIJ; Mawson A; Schafranek P; Steinmann AM; Nessem D; Parkin A; Johns A; Chou A; Law AMK; Lucas MC; Murphy KJ; Deng N; Gallego-Ortega D; Caldon CE; Timpson P; Pajic M; Ormandy CJ; Oakes SR, 2020, 'MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma', Oncogene, 39, pp. 1821 - 1829,
    Journal articles | 2020
    Chitty JL; Skhinas JN; Filipe EC; Wang S; Cupello CR; Grant RD; Yam M; Papanicolaou M; Major G; Zaratzian A; Da Silva AM; Tayao M; Vennin C; Timpson P; Madsen CD; Cox TR, 2020, 'The Mini-Organo: A rapid high-throughput 3D coculture organotypic assay for oncology screening and drug development', Cancer Reports, 3,
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    Cipponi A; Goode DL; Bedo J; McCabe MJ; Pajic M; Croucher DR; Rajal AG; Junankar SR; Saunders DN; Lobachevsky P; Papenfuss AT; Nessem D; Nobis M; Warren SC; Timpson P; Cowley M; Vargas AC; Qiu MR; Generali DG; Keerthikumar S; Nguyen U; Corcoran NM; Long GV; Blay J-Y; Thomas DM; McCabe M, 2020, 'MTOR signaling orchestrates stress-induced mutagenesis, facilitating adaptive evolution in cancer', Science
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    Follain G; Herrmann D; Harlepp S; Hyenne V; Osmani N; Warren SC; Timpson P; Goetz JG, 2020, 'Fluids and their mechanics in tumour transit: shaping metastasis', Nature Reviews Cancer, 20, pp. 107 - 124,
    Journal articles | 2020
    Gonzalez-Rajal A; Marzec K; McCloy R; Nobis M; Chin V; Hastings J; Lai K; Kennerson M; Hughes W; Vaghjiani V; Timpson P; Cain J; Neil Watkins D; Croucher D; Burgess A, 2020, 'A Non-Genetic, Cell Cycle Dependent Mechanism of Platinum Resistance in Lung Adenocarcinoma', ,
    Journal articles | 2020
    Hoque M; Elmaghrabi YA; Köse M; Beevi SS; Jose J; Meneses-Salas E; Blanco-Muñoz P; Conway JRW; Swarbrick A; Timpson P; Tebar F; Enrich C; Rentero C; Grewal T, 2020, 'Annexin A6 improves anti-migratory and anti-invasive properties of tyrosine kinase inhibitors in EGFR overexpressing human squamous epithelial cells', FEBS Journal, 287, pp. 2961 - 2978,
    Journal articles | 2020
    Kokkinos J; Ignacio RMC; Sharbeen G; Boyer C; Gonzales-Aloy E; Goldstein D; McCarroll JA; Phillips PA, 2020, 'Targeting the undruggable in pancreatic cancer using nano-based gene silencing drugs', Biomaterials, 240,
    Journal articles | 2020
    Lamm N; Read MN; Nobis M; Van Ly D; Page SG; Masamsetti VP; Timpson P; Biro M; Cesare AJ, 2020, 'Nuclear F-actin counteracts nuclear deformation and promotes fork repair during replication stress', Nature Cell Biology, 22, pp. 1460 - 1470,
    Journal articles | 2020
    Nobis M; Herrmann D; Warren SC; Strathdee D; Cox TR; Anderson KI; Timpson P, 2020, 'Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse', Small GTPases, 11, pp. 240 - 247,
    Journal articles | 2020
    Ritchie S; Pereira BA; Vennin C; Timpson P, 2020, 'Targeting genetically-tuned CAFs in pancreatic cancer via perlecan manipulation', Expert Opinion on Therapeutic Targets, 24, pp. 171 - 174,
    Journal articles | 2020
    Srijakotre N; Liu HJ; Nobis M; Man J; Yip HYK; Papa A; Abud HE; Anderson KI; Welch HCE; Tiganis T; Timpson P; McLean CA; Ooms LM; Mitchell CA, 2020, 'PtdIns(3,4,5)P3-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis', Proceedings of the National Academy of Sciences of the United States of America, 117, pp. 28056 - 28067,
    Journal articles | 2020
    Vennin C; Rath N; Pajic M; Olson MF; Timpson P, 2020, 'Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy', Small GTPases, 11, pp. 45 - 52,
    Journal articles | 2020
    Wang K; Zhan Y; Huynh N; Dumesny C; Wang X; Asadi K; Herrmann D; Timpson P; Yang Y; Walsh K; Baldwin GS; Nikfarjam M; He H, 2020, 'Inhibition of PAK1 suppresses pancreatic cancer by stimulation of anti-tumour immunity through down-regulation of PD-L1', Cancer Letters, 472, pp. 8 - 18,
    Journal articles | 2020
    Wu S; Roden D; Wang C; Holliday H; Harvey K; Cazet A; Murphy K; Pereira B; Al-Eryani G; Bartonicek N; Hou R; Torpy J; Junankar S; Chan C-L; Lam E; Hui M; Gluch L; Beith J; Parker A; Robbins E; Segara D; Mak C; Cooper C; Warrier S; Forrest A; Powell J; O’Toole S; Cox T; Timpson P; Lim E; Liu S; Swarbrick A, 2020, 'Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer', bioRxiv,
    Journal articles | 2020
    Wu SZ; Roden DL; Wang C; Holliday H; Harvey K; Cazet AS; Murphy KJ; Pereira B; Al-Eryani G; Bartonicek N; Hou R; Torpy JR; Junankar S; Chan CL; Lam CE; Hui MN; Gluch L; Beith J; Parker A; Robbins E; Segara D; Mak C; Cooper C; Warrier S; Forrest A; Powell J; O'Toole S; Cox TR; Timpson P; Lim E; Liu XS; Swarbrick A, 2020, 'Stromal cell diversity associated with immune evasion in human triple-negative breast cancer', EMBO Journal, 39, pp. embj2019104063,
    Journal articles | 2019
    Campbell H; Fleming N; Roth I; Vennin C; Wile A; Mccall J; Mehta S; Williams G; Timpson P; Roux P; Baird M; Braithwaite A, 2019, 'IL-6 signalling mediates tumorigenesis, invasion and metastasis driven by the 33p53 isoform', Nature Communications
    Journal articles | 2019
    Christodoulou N; Weberling A; Strathdee D; Anderson KI; Timpson P; Zernicka-Goetz M, 2019, 'Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation', Nature Communications, 10,
    Journal articles | 2019
    Conway JR; Herrmann D; Evans TJ; Morton JP; Timpson P, 2019, 'Combating pancreatic cancer with PI3K pathway inhibitors in the era of personalised medicine', Gut, 68, pp. 742 - 758,
    Journal articles | 2019
    Kennedy SP; Han JZR; Portman N; Nobis M; Hastings JF; Murphy KJ; Latham SL; Cadell AL; Miladinovic D; Marriott GR; O'Donnell YEI; Shearer RF; Williams JT; Munoz AG; Cox TR; Watkins DN; Saunders DN; Timpson P; Lim E; Kolch W; Croucher DR, 2019, 'Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer', Breast Cancer Research, 21,
    Journal articles | 2019
    Nobis M; Lucas M; Warren S; Murphy K; Herrmann D; Timpson P, 2019, 'Moving molecular mobility to in vivo disease settings', Gastroenterology
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    Parkin A; Man J; Timpson P; Pajic M, 2019, 'Targeting the complexity of Src signalling in the tumour microenvironment of pancreatic cancer: from mechanism to therapy', FEBS Journal, 286, pp. 3510 - 3539,
    Journal articles | 2019
    Pereira BA; Vennin C; Papanicolaou M; Chambers CR; Herrmann D; Morton JP; Cox TR; Timpson P, 2019, 'CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer', Trends in Cancer, 5, pp. 724 - 741,
    Journal articles | 2019
    Valdes-Mora F; Salomon R; Gloss B; Law AMK; Castillo L; Murphy K; Venhuizen J; Magenau A; Papanicolau M; de la Fuente LR; Roden D; Colino-Sanguino Y; Kikhtyak Z; Farbehi N; Conway JRW; Oakes S; Sikta N; O’Donoghue S; Cox T; Timpson P; Ormandy C; Gallego-Ortega D, 2019, 'Single cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype', ,
    Journal articles | 2019
    Valdes-Mora F; Salomon R; Gloss B; Law AMK; Murphy K; Roden DL; Castillo L; Colino-Sanguino Y; Farbehi N; Conway J; Timpson P; Ormandy CJ; Gallego-Ortega D, 2019, 'Characterisation of developmental pathways that drive metastatic progression of breast cancer at single cell resolution', Oncology Abstracts,
    Journal articles | 2019
    Vennin C; Mélénec P; Rouet R; Nobis M; Cazet AS; Murphy KJ; Herrmann D; Reed DA; Lucas MC; Warren SC; Elgundi Z; Pinese M; Kalna G; Roden D; Samuel M; Zaratzian A; Grey ST; Da Silva A; Leung W; Johns AL; Chantrill LA; Chou A; Steinmann A; Arshi M; Dwarte T; Froio D; Pereira B; Ritchie S; Chambers CR; Metcalf X; Waddell N; Pearson JV; Patch AM; Nones K; Newell F; Mukhopadhyay P; Addala V; Kazakoff S; Holmes O; Leonard C; Wood S; Grimmond SM; Hofmann O; Christ A; Bruxner T; Samra JS; Pavlakis N; High HA; Asghari R; Merrett ND; Pavey D; Das A; Cosman PH; Ismail K; O’Connnor C; Stoita A; Williams D; Spigellman A; Lam VW; McLeod D; Kirk J; Kench JG; Grimison P; Cooper CL; Sandroussi C; Goodwin A; Mead RS; Tucker K; Andrews L; Texler M; Forest C; Epari KP; Ballal M; Fletcher DR; Mukhedkar S; Zeps N; Beilin M; Feeney K; Nguyen NQ; Ruszkiewicz AR; Worthley C; Chen J; Brooke-Smith ME; Papangelis V; Clouston AD; Barbour AP; O’Rourke TJ; Fawcett JW; Slater K; Hatzifotis M; Hodgkinson P; Nikfarjam M; Eshleman JR; Hruban RH; Wolfgang CL; Lawlor RT; Beghelli S; Corbo V; Scardoni M; Bassi C; Christ D; Cox T; Timpson P; Phillips P; Whitelock J; Pajic M; Gill A; Croucher D, 2019, 'CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan', Nature Communications, 10, pp. 3637,
    Journal articles | 2019
    Warren S; Magenau A; Nobis M; Mohammed Y; Melenec P; Phan T; Roberts M; Timpson P, 2019, 'Galene: correcting physiological motion blurring at the subcellular level in intravital FLIM data', eLife, 7,
    Journal articles | 2018
    Benthani F; Herrman D; Tran P; Pangon L; Currey N; Lucas M; Allam A; Giry-Laterriere M; Al-Sohaily S; Timpson P; Kohonen-Corish M, 2018, 'Mutated in colorectal cancer protein strengthens the intercellular adhesion of colon cancer cells by complexing with E-cadherin and beta-catenin', Oncogene
    Journal articles | 2018
    Campbell H; Fleming N; Roth I; Mehta S; Wiles A; Williams G; Vennin C; Arsic N; Parkin A; Pajic M; Munro F; McNoe L; Black M; McCall J; Slatter TL; Timpson P; Reddel R; Roux P; Print C; Baird MA; Braithwaite AW, 2018, 'Δ133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signaling', Nature Communications, 9,
    Journal articles | 2018
    Cazet AS; Hui MN; Elsworth BL; Wu SZ; Roden D; Chan CL; Skhinas JN; Collot R; Yang J; Harvey K; Johan MZ; Cooper C; Nair R; Herrmann D; McFarland A; Deng N; Ruiz-Borrego M; Rojo F; Trigo JM; Bezares S; Caballero R; Lim E; Timpson P; O’Toole S; Watkins DN; Cox TR; Samuel MS; Martín M; Swarbrick A; O'Toole S, 2018, 'Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer', Nature Communications, 9, pp. 2897,
    Journal articles | 2018
    Chitty JL; Filipe EC; Lucas MC; Herrmann D; Cox TR; Timpson P, 2018, 'Recent advances in understanding the complexities of metastasis', F1000Research, 7,
    Journal articles | 2018
    Chou A; Froio D; Nagrial AM; Parkin A; Murphy KJ; Chin VT; Wohl D; Steinmann A; Stark R; Drury A; Walters SN; Vennin C; Burgess A; Pinese M; Chantrill LA; Cowley MJ; Molloy TJ; Waddell N; Johns A; Grimmond SM; Chang DK; Biankin AV; Sansom OJ; Morton JP; Grey ST; Cox TR; Turchini J; Samra J; Clarke SJ; Timpson P; Gill AJ; Pajic M, 2018, 'Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer', Gut, 67, pp. 2142 - 2155,
    Journal articles | 2018
    Conway JRW; Warren SC; Herrmann D; Murphy KJ; Cazet AS; Vennin C; Shearer RF; Killen MJ; Magenau A; Mélénec P; Pinese M; Nobis M; Zaratzian A; Boulghourjian A; Da Silva AM; del Monte-Nieto G; Adam ASA; Harvey RP; Haigh JJ; Wang Y; Croucher DR; Sansom OJ; Pajic M; Caldon CE; Morton JP; Timpson P; del Monte Nieto G; Gallego-Ortega D, 2018, 'Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer', Cell Reports, 23, pp. 3312 - 3326,
    Journal articles | 2018
    Firatligil B; Bati-Ayaz G; Pesen-Okvur D; Yalcin-Ozuysal O, 2018, 'PO-171 Tissue specific extravasation and invasion of MDA-MB-231 cells in a lab-on-a-chip system', ESMO Open, 3, pp. A88 - A88,
    Journal articles | 2018
    Kalimutho M; Sinha D; Jeffery J; Nones K; Srihari S; Fernando WC; Duijf PHG; Vennin C; Raninga P; Nanayakkara D; Mittal D; Saunus JM; Lakhani SR; López JA; Spring KJ; Timpson P; Gabrielli B; Waddell N; Khanna KK, 2018, 'CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer', EMBO Molecular Medicine, 10,
    Journal articles | 2018
    Kohonen-Corish M; Benthani F; Herrmann D; Phuong T; Currey N; Lucas M; Allam A; Al-Sohaily S; Warusavitarne J; Timpson P, 2018, 'PO-168 Loss of the MCC gene expression promotes invasiveness of colon cancer cells', ESMO Open, 3, pp. A86 - A87,
    Journal articles | 2018
    Lancaster GI; Langley KG; Berglund NA; Kammoun HL; Reibe S; Estevez E; Weir J; Mellett NA; Pernes G; Conway JRW; Lee MKS; Timpson P; Murphy AJ; Masters SL; Gerondakis S; Bartonicek N; Kaczorowski DC; Dinger ME; Meikle PJ; Bond PJ; Febbraio MA, 2018, 'Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism', Cell Metabolism, 27, pp. 1096 - 1110.e5,
    Journal articles | 2018
    Molloy T; Parkin A; Chou A; Samra J; Timpson P; Gill A; Pajic M, 2018, 'PO-195 Integrative analysis of in vivo models of pancreatic cancer reveals complex mechanisms behind treatment failure and provides new tools for effective targeting', ESMO Open, 3, pp. A303 - A303,
    Journal articles | 2018
    Murphy K; Vennin C; Cox T; Wang Y; Morton J; Sansom O; Pajic M; Herrmann D; Timpson P, 2018, 'PO-229 Transient tissue ‘priming’ via FAK inhibition to impair pancreatic ductal adenocarcinoma (PDAC) progression to improve sensitivity to gemcitabine/abraxane', ESMO Open, 3, pp. A316 - A317,
    Journal articles | 2018
    Nobis M; Warren SC; Lucas MC; Murphy KJ; Herrmann D; Timpson P, 2018, 'Molecular mobility and activity in an intravital imaging setting - Implications for cancer progression and targeting', Journal of Cell Science, 131,
    Journal articles | 2018
    Parkin A; Man J; Chou A; Nagrial AM; Samra J; Gill AJ; Timpson P; Pajic M, 2018, 'The Evolving Understanding of the Molecular and Therapeutic Landscape of Pancreatic Ductal Adenocarcinoma.', Diseases, 6,
    Journal articles | 2018
    Parkin A; Steinmann A; Froio D; Drury A; Vogel N; Murphy K; Deng N; Gill A; Timpson P; Pajic M, 2018, 'PO-046 Dual inhibition of JAK and Src: a novel and promising therapeutic combination for pancreatic cancer', ESMO Open, 3, pp. A245 - A245,
    Journal articles | 2018
    Pinho AV; Van Bulck M; Chantrill L; Arshi M; Sklyarova T; Herrmann D; Vennin C; Gallego-Ortega D; Mawson A; Giry-Laterriere M; Magenau A; Leuckx G; Baeyens L; Gill AJ; Phillips P; Timpson P; Biankin AV; Wu J; Rooman I, 2018, 'ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling', Nature Communications, 9,
    Journal articles | 2018
    Rath N; Munro J; Cutiongco MF; Jagiełło A; Gadegaard N; McGarry L; Unbekandt M; Michalopoulou E; Kamphorst JJ; Sumpton D; Mackay G; Vennin C; Pajic M; Timpson P; Olson MF, 2018, 'Rho kinase inhibition by AT13148 blocks pancreatic ductal adenocarcinoma invasion and tumor growth', Cancer Research, 78, pp. 3321 - 3336,
    Journal articles | 2018
    Rogers S; McCloy RA; Parker BL; Gallego-Ortega D; Law AMK; Chin VT; Conway JRW; Fey D; Millar EKA; O’Toole S; Deng N; Swarbrick A; Chastain PD; Cesare AJ; Timpson P; Caldon CE; Croucher DR; James DE; Watkins DN; Burgess A, 2018, 'MASTL overexpression promotes chromosome instability and metastasis in breast cancer', Oncogene, 37, pp. 4518 - 4533,
    Journal articles | 2018
    Salaymeh Y; Farago M; Sebban S; Pikarsky E; Katzav S, 2018, 'PO-196 Vav1 and Mutant K-Ras synergize in pancreatic ductal adenocarcinoma development: lessons from mouse models', ESMO Open, 3, pp. A303 - A303,
    Journal articles | 2018
    Vennin C; Murphy KJ; Morton JP; Cox TR; Pajic M; Timpson P, 2018, 'Reshaping the Tumor Stroma for Treatment of Pancreatic Cancer', Gastroenterology, 154, pp. 820 - 838,
    Journal articles | 2018
    Warren SC; Nobis M; Magenau A; Mohammed YH; Herrmann D; Moran I; Vennin C; Conway JRW; Mélénec P; Cox TR; Wang Y; Morton JP; Welch HCE; Strathdee D; Anderson KI; Phan TG; Roberts MS; Timpson P, 2018, 'Removing physiological motion from Intravital and clinical functional imaging data', eLife, 7,
    Journal articles | 2018
    Young AIJ; Timpson P; Gallego-Ortega D; Ormandy CJ; Oakes SR, 2018, 'Myeloid cell leukemia 1 (MCL-1), an unexpected modulator of protein kinase signaling during invasion', Cell Adhesion and Migration, 12, pp. 513 - 523,
    Journal articles | 2017
    Andrlová H; Mastroianni J; Madl J; Kern JS; Melchinger W; Dierbach H; Wernet F; Follo M; Hafsi KT; Has C; Mittapalli VR; Idzko M; Herr R; Brummer T; Ungefroren H; Busch H; Boerries M; Narr A; Ihorst G; Vennin C; Schmitt-Graeff A; Minguet S; Timpson P; Duyster J; Meiss F; Römer W; Zeiser R, 2017, 'Biglycan expression in the melanoma microenvironment promotes invasiveness via increased tissue stiffness inducing integrin-β1 expression', Oncotarget, 8, pp. 42901 - 42916,
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    Journal articles | 2017
    Chang J; Lucas MC; Leonte LE; Garcia-Montolio M; Singh LB; Findlay AD; Deodhar M; Foot JS; Jarolimek W; Timpson P; Erler JT; Cox TR, 2017, 'Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer', Oncotarget, 8, pp. 26066 - 26078,
    Journal articles | 2017
    Chin VT; Vennin C; Timpson P; Pajic M, 2017, 'Effective modulation of stromal signaling through ROCK inhibition: Is it all in the timing?', Molecular and Cellular Oncology, 4,
    Journal articles | 2017
    Conway JRW; Vennin C; Cazet AS; Herrmann D; Murphy KJ; Warren SC; Wullkopf L; Boulghourjian A; Zaratzian A; Da Silva AM; Pajic M; Morton JP; Cox TR; Timpson P, 2017, 'Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology', Scientific Reports, 7, pp. 16887,
    Journal articles | 2017
    Conway JRW; Warren SC; Timpson P, 2017, 'Context-dependent intravital imaging of therapeutic response using intramolecular FRET biosensors', Methods, 128, pp. 78 - 94,
    Journal articles | 2017
    Grewal T; Hoque M; Conway JRW; Reverter M; Wahba M; Beevi SS; Timpson P; Enrich C; Rentero C, 2017, 'Annexin A6 - a multifunctional scaffold in cell motility.', Cell Adh Migr,
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    Grewal T; Hoque M; Conway JRW; Reverter M; Wahba M; Beevi SS; Timpson P; Enrich C; Rentero C, 2017, 'Annexin A6—A multifunctional scaffold in cell motility', Cell Adhesion and Migration, 11, pp. 288 - 304,
    Journal articles | 2017
    Harris NLE; Vennin C; Conway JRW; Vine KL; Pinese M; Cowley MJ; Shearer RF; Lucas MC; Herrmann D; Allam AH; Pajic M; Morton JP; Biankin AV; Ranson M; Timpson P; Saunders DN, 2017, 'SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer', Oncogene, 36, pp. 4288 - 4298,
    Journal articles | 2017
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    Journal articles | 2017
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    Journal articles | 2017
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    Timpson P, 2017, 'Cell scientist to watch – Paul Timpson', Journal of Cell Science, 130, pp. 2949 - 2951,
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    Vennin C; Chin VT; Warren SC; Lucas MC; Herrmann D; Magenau A; Melenec P; Walters SN; Del Monte-Nieto G; Conway JRW; Nobis M; Allam AH; McCloy RA; Currey N; Pinese M; Boulghourjian A; Zaratzian A; Adam AAS; Heu C; Nagrial AM; Chou A; Steinmann A; Drury A; Froio D; Giry-Laterriere M; Harris NLE; Phan T; Jain R; Weninger W; McGhee EJ; Whan R; Johns AL; Samra JS; Chantrill L; Gill AJ; Kohonen-Corish M; Harvey RP; Biankin AV; Evans TRJ; Anderson KI; Grey ST; Ormandy CJ; Gallego-Ortega D; Wang Y; Samuel MS; Sansom OJ; Burgess A; Cox TR; Morton JP; Pajic M; Timpson P, 2017, 'Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis', Science Translational Medicine, 9,
    Journal articles | 2017
    Vennin C; Cox TR; Pajic M; Timpson P, 2017, 'Transient targeting of the pancreatic cancer stroma as a 'finetuned' anti-tumor and anti-metastatic therapy', Oncotarget, 8, pp. 84635 - 84636,
    Journal articles | 2016
    Akerman A; Vennin C; Sharbeen G; Warren SC; Timpson P; Phillips PA, 2016, 'Novel therapeutics and preclinical imaging for pancreatic cancer - View from the lab', Cancer Forum, 40, pp. 16 - 22
    Journal articles | 2016
    Andrlova H; Mastroianni J; Madl J; Kern JS; Melchinger W; Follo M; Technau-Hafsi K; Mittapali VR; Brummer T; Timpson P; Ungefroren H; Duyster J; Meiss F; Römer W; Zeiser R, 2016, 'Effect of biglycan on melanoma invasiveness via increased tissue stiffness and integrin-β1 expression.', Journal of Clinical Oncology, 34, pp. 11526 - 11526,
    Journal articles | 2016
    Appaduray MA; Masedunskas A; Bryce NS; Lucas CA; Warren SC; Timpson P; Stear JH; Gunning PW; Hardeman EC, 2016, 'Recruitment kinetics of tropomyosin tpm3.1 to actin filament bundles in the cytoskeleton is independent of actin filament kinetics', PLoS ONE, 11, pp. e0168203,
    Journal articles | 2016
    Erami Z; Herrmann D; Warren SC; Nobis M; McGhee EJ; Lucas MC; Leung W; Reischmann N; Mrowinska A; Schwarz JP; Kadir S; Conway JRW; Vennin C; Karim SA; Campbell AD; Gallego-Ortega D; Magenau A; Murphy KJ; Ridgway RA; Law AM; Walters SN; Grey ST; Croucher DR; Zhang L; Herzog H; Hardeman EC; Gunning PW; Ormandy CJ; Evans TRJ; Strathdee D; Sansom OJ; Morton JP; Anderson KI; Timpson P; Zhang L, 2016, 'Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue', Cell Reports, 14, pp. 152 - 167,
    Journal articles | 2016
    García-Melero A; Reverter M; Hoque M; Meneses-Salas E; Koese M; Conway JRW; Johnsen CH; Alvarez-Guaita A; Morales-Paytuvi F; Elmaghrabi YA; Pol A; Tebar F; Murray RZ; Timpson P; Enrich C; Grewal T; Rentero C, 2016, 'Annexin A6 and late endosomal cholesterol modulate integrin recycling and cell migration', Journal of Biological Chemistry, 291, pp. 1320 - 1335,
    Journal articles | 2016
    Marei H; Carpy A; Woroniuk A; Vennin C; White G; Timpson P; Macek B; Malliri A, 2016, 'Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration', Nature Communications, 7,
    Journal articles | 2016
    Nobis M; Herrmann D; Timpson P; Erami Z; Anderson K, 2016, 'Imaging Molecular Dynamics for Drug Discovery', Physiology News, pp. 27 - 29,
    Journal articles | 2016
    Roth I; Campbell H; Rubio C; Vennin C; Wilson M; Wiles A; Williams G; Woolley A; Timpson P; Berridge MV; Fleming N; Baird M; Braithwaite AW, 2016, 'The Δ133p53 isoform and its mouse analogue Δ122p53 promote invasion and metastasis involving pro-inflammatory molecules interleukin-6 and CCL2', Oncogene, 35, pp. 4981 - 4989,
    Journal articles | 2016
    Vennin C; Herrmann D; Lucas MC; Timpson P, 2016, 'Intravital imaging reveals new ancillary mechanisms co-opted by cancer cells to drive tumor progression.', F1000Research, 5,
    Journal articles | 2016
    Young AIJ; Law AMK; Castillo L; Chong S; Cullen HD; Koehler M; Herzog S; Brummer T; Lee EF; Fairlie WD; Lucas MC; Herrmann D; Allam A; Timpson P; Watkins DN; Millar EKA; O'Toole SA; Gallego-Ortega D; Ormandy CJ; Oakes SR, 2016, 'MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib', Breast Cancer Research, 18,
    Journal articles | 2015
    Belle L; Ali N; Lonic A; Li X; Paltridge JL; Roslan S; Herrmann D; Conway JRW; Gehling FK; Bert AG; Crocker LA; Tsykin A; Farshid G; Goodall GJ; Timpson P; Daly RJ; Khew-Goodall Y, 2015, 'The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking', Science Signaling, 8,
    Journal articles | 2015
    Chin VT; Nagrial AM; Chou A; Biankin AV; Gill AJ; Timpson P; Pajic M, 2015, 'Rho-associated kinase signalling and the cancer microenvironment: Novel biological implications and therapeutic opportunities', Expert Reviews in Molecular Medicine, 17,
    Journal articles | 2015
    Erami Z; Timpson P; Yao W; Zaidel-Bar R; Anderson KI, 2015, 'There are four dynamically and functionally distinct populations of E-cadherin in cell junctions', Biology Open, 4, pp. 1481 - 1489,
    Journal articles | 2015
    Gallego-Ortega D; Ledger A; Roden DL; Law AMK; Magenau A; Kikhtyak Z; Cho C; Allerdice SL; Lee HJ; Valdes-Mora F; Herrmann D; Salomon R; Young AIJ; Lee BY; Sergio CM; Kaplan W; Piggin C; Conway JRW; Rabinovich B; Millar EKA; Oakes SR; Chtanova T; Swarbrick A; Naylor MJ; O’Toole S; Green AR; Timpson P; Gee JMW; Ellis IO; Clark SJ; Ormandy CJ, 2015, 'ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells', PLoS Biology, 13,
    Journal articles | 2015
    Hoque M; Rentero C; Conway JR; Murray RZ; Timpson P; Enrich C; Grewal T, 2015, 'The cross-talk of LDL-cholesterol with cell motility: Insights from the niemann pick type C1 mutation and altered integrin trafficking', Cell Adhesion and Migration, 9, pp. 384 - 391,
    Journal articles | 2015
    Huo CW; Chew G; Hill P; Huang D; Ingman W; Hodson L; Brown KA; Magenau A; Allam AH; McGhee E; Timpson P; Henderson MA; Thompson EW; Britt K, 2015, 'High mammographic density is associated with an increase in stromal collagen and immune cells within the mammary epithelium', Breast Cancer Research, 17,
    Journal articles | 2015
    Kular J; Scheer KG; Pyne NT; Allam AH; Pollard AN; Magenau A; Wright RL; Kolesnikoff N; Moretti PA; Wullkopf L; Stomski FC; Cowin AJ; Woodcock JM; Grimbaldeston MA; Pitson SM; Timpson P; Ramshaw HS; Lopez AF; Samuel MS, 2015, 'A Negative Regulatory Mechanism Involving 14-3-3ζ Limits Signaling Downstream of ROCK to Regulate Tissue Stiffness in Epidermal Homeostasis', Developmental Cell, 35, pp. 759 - 774,
    Journal articles | 2015
    Lee BY; Timpson P; Horvath LG; Daly RJ, 2015, 'FAK signaling in human cancer as a target for therapeutics', Pharmacology & therapeutics, 146, pp. 132 - 149,
    Journal articles | 2015
    Miller BW; Morton JP; Pinese M; Saturno G; Jamieson NB; Mcghee E; Timpson P; Leach J; Mcgarry L; Shanks E; Bailey P; Chang D; Oien K; Karim S; Au A; Steele C; Carter CR; Mckay C; Anderson K; Evans TRJ; Marais R; Springer C; Biankin A; Erler JT; Sansom OJ, 2015, 'Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: Inhibition of LOX abrogates metastasis and enhances drug efficacy', EMBO Molecular Medicine, 7, pp. 1063 - 1076,
    Journal articles | 2015
    Ooms LM; Binge LC; Davies EM; Rahman P; Conway JRW; Gurung R; Ferguson DT; Papa A; Fedele CG; Vieusseux JL; Chai RC; Koentgen F; Price JT; Tiganis T; Timpson P; McLean CA; Mitchell CA, 2015, 'The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis', Cancer Cell, 28, pp. 155 - 169,
    Journal articles | 2015
    Pajic M; Herrmann D; Vennin C; Conway JRW; Chin VT; Johnsson AKE; Welch HCE; Timpson P, 2015, 'The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment', Small GTPases, 6, pp. 123 - 133,
    Journal articles | 2015
    Vennin C; Pajic M; Timpson P, 2015, 'Imaging fibrosis in pancreatic cancer using second harmonic generation', Pancreatology, 15, pp. 200 - 201,
    Journal articles | 2015
    Vennin C; Timpson P, 2015, 'Intravital microscopy of cancer: New insights into the spatiotemporal dynamics of the disease', AACR Education book, 2015, pp. 31 - 36,
    Journal articles | 2015
    Vlahov N; Scrace S; Soto MS; Grawenda AM; Bradley L; Pankova D; Papaspyropoulos A; Yee KS; Buffa F; Goding CR; Timpson P; Sibson N; O'Neill E, 2015, 'Alternate RASSF1 transcripts control SRC activity, E-cadherin contacts, and YAP-mediated invasion', Current Biology, 25, pp. 3019 - 3034,
    Journal articles | 2014
    Conway JRW; Carragher NO; Timpson P, 2014, 'Developments in preclinical cancer imaging: Innovating the discovery of therapeutics', Nature Reviews Cancer, 14, pp. 314 - 328,
    Journal articles | 2014
    Herrmann D; Conway JRW; Vennin C; Magenau A; Hughes WG; Morton JP; Timpson P, 2014, 'Three-dimensional cancer models mimic cell-matrix interactions in the tumour microenvironment', Carcinogenesis, 35, pp. 1671 - 1679,
    Journal articles | 2014
    Johnsson AKE; Dai Y; Nobis M; Baker MJ; McGhee EJ; Walker S; Schwarz JP; Kadir S; Morton JP; Myant KB; Huels DJ; Segonds-Pichon A; Sansom OJ; Anderson KI; Timpson P; Welch HCE, 2014, 'The Rac-FRET Mouse Reveals Tight Spatiotemporal Control of Rac Activity in Primary Cells and Tissues', Cell Reports, 6, pp. 1153 - 1164,
    Journal articles | 2014
    Macpherson IR; Rainero E; Mitchell LE; van den Berghe PVE; Speirs C; Dozynkiewicz MA; Chaudhary S; Kalna G; Edwards J; Timpson P; Norman JC, 2014, 'CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer', Journal of Cell Science, 127, pp. 3893 - 3901,
    Journal articles | 2014
    Nobis M; McGhee EJ; Herrmann D; Magenau A; Morton JP; Anderson KI; Timpson P, 2014, 'Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging', Cell Adhesion and Migration, 8, pp. 478 - 486,
    Journal articles | 2014
    Reverter M; Rentero C; Garcia-Melero A; Hoque M; Vilà de Muga S; Álvarez-Guaita A; Conway JRW; Wood P; Cairns R; Lykopoulou L; Grinberg D; Vilageliu L; Bosch M; Heeren J; Blasi J; Timpson P; Pol A; Tebar F; Murray RZ; Grewal T; Enrich C, 2014, 'Cholesterol Regulates Syntaxin 6 Trafficking at trans-Golgi Network Endosomal Boundaries', Cell Reports, 7, pp. 883 - 897,
    Journal articles | 2014
    Tan EH; Morton JP; Timpson P; Tucci P; Melino G; Flores ER; Sansom OJ; Vousden KH; Muller PAJ, 2014, 'Functions of TAp63 and p53 in restraining the development of metastatic cancer', British Dental Journal, 217, pp. 3325 - 3333,
    Journal articles | 2013
    Chin VT; Nagrial A; Chantrill LA; Chang DK; Chou A; Humprhis J; Cowley M; Wu J; DiPetro R; Watson C; Spielman C; Steinmann A; Pinese M; Pettitt J; Johns A; Waddell N; Grimmond S; Timpson P; Biankin AV; Pajic M, 2013, 'From functional genomics to precision medicine: The therapeutic potential of targeting ROCK signaling in pancreatic cancer.', Journal of Clinical Oncology, 31, pp. e15029 - e15029,
    Journal articles | 2013
    Muller PAJ; Trinidad AG; Timpson P; Morton JP; Zanivan S; Van Den Berghe PVE; Nixon C; Karim SA; Caswell PT; Noll JE; Coffill CR; Lane DP; Sansom OJ; Neilsen PM; Norman JC; Vousden KH, 2013, 'Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion', Oncogene, 32, pp. 1252 - 1265,
    Journal articles | 2013
    Myant KB; Cammareri P; McGhee EJ; Ridgway RA; Huels DJ; Cordero JB; Schwitalla S; Kalna G; Ogg EL; Athineos D; Timpson P; Vidal M; Murray GI; Greten FR; Anderson KI; Sansom OJ, 2013, 'ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation', Cell Stem Cell, 12, pp. 761 - 773,
    Journal articles | 2013
    Nobis M; Carragher NO; McGhee EJ; Morton JP; Sansom OJ; Anderson KI; Timpson P, 2013, 'Advanced intravital subcellular imaging reveals vital three-dimensional signalling events driving cancer cell behaviour and drug responses in live tissue', FEBS Journal, 280, pp. 5177 - 5197,
    Journal articles | 2013
    Nobis M; McGhee EJ; Morton JP; Schwarz JP; Karim SA; Quinn J; Edward M; Campbell AD; McGarry LC; Evans TRJ; Brunton VG; Frame MC; Carragher NO; Wang Y; Sansom OJ; Timpson P; Anderson KI, 2013, 'Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of Src in pancreatic cancer', Cancer Research, 73, pp. 4674 - 4686,
    Journal articles | 2013
    Tang H; Li A; Bi J; Veltman DM; Zech T; Spence HJ; Yu X; Timpson P; Insall RH; Frame MC; MacHesky LM, 2013, 'Loss of scar/WAVE complex promotes N-WASP- and FAK-dependent invasion', Current Biology, 23, pp. 107 - 117,
    Journal articles | 2012
    Dawson JC; Timpson P; Kalna G; Machesky LM, 2012, 'Mtss1 regulates epidermal growth factor signaling in head and neck squamous carcinoma cells', Oncogene, 31, pp. 1781 - 1793,
    Journal articles | 2012
    Dozynkiewicz MA; Jamieson NB; MacPherson I; Grindlay J; vandenBerghe PVE; vonThun A; Morton JP; Gourley C; Timpson P; Nixon C; McKay CJ; Carter R; Strachan D; Anderson K; Sansom OJ; Caswell PT; Norman JC, 2012, 'Rab25 and CLIC3 Collaborate to Promote Integrin Recycling from Late Endosomes/Lysosomes and Drive Cancer Progression', Developmental Cell, 22, pp. 131 - 145,
    Journal articles | 2012
    Macintosh RL; Timpson P; Thorburn J; Anderson KI; Thorburn A; Ryan KM, 2012, 'Inhibition of autophagy impairs tumor cell invasion in an organotypic model', Cell Cycle, 11, pp. 2022 - 2029,
    Journal articles | 2012
    Spence HJ; Timpson P; Tang HR; Insall RH; Machesky LM, 2012, 'Scar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in three dimensions', Biochemical Journal, 448, pp. 35 - 42,
    Journal articles | 2012
    Yu X; Zech T; McDonald L; Gonzalez EG; Li A; Macpherson I; Schwarz JP; Spence H; Futó K; Timpson P; Nixon C; Ma Y; Anton IM; Visegrády B; Insall RH; Oien K; Blyth K; Norman JC; Machesky LM, 2012, 'N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods', Journal of Cell Biology, 199, pp. 527 - 544,
    Journal articles | 2011
    Isherwood B; Timpson P; Mcghee EJ; Anderson KI; Canel M; Serrels A; Brunton VG; Carragher NO, 2011, 'Live cell in vitro and in vivo imaging applications: Accelerating drug discovery', Pharmaceutics, 3, pp. 141 - 170,
    Journal articles | 2011
    Lindsay CR; Lawn S; Campbell AD; Faller WJ; Rambow F; Mort RL; Timpson P; Li A; Cammareri P; Ridgway RA; Morton JP; Doyle B; Hegarty S; Rafferty M; Murphy IG; McDermott EW; Sheahan K; Pedone K; Finn AJ; Groben PA; Thomas NE; Hao H; Carson C; Norman JC; MacHesky LM; Gallagher WM; Jackson IJ; Van Kempen L; Beermann F; Der C; Larue L; Welch HC; Ozanne BW; Sansom OJ, 2011, 'P-Rex1 is required for efficient melanoblast migration and melanoma metastasis', Nature Communications, 2,
    Journal articles | 2011
    McGhee EJ; Morton JP; von Kriegsheim A; Schwarz JP; Karim SA; Carragher NO; Sansom OJ; Anderson KI; Timpson P, 2011, 'FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion', Small GTPases, 2, pp. 239 - 244,
    Journal articles | 2011
    Samuel MS; Lopez JI; McGhee EJ; Croft DR; Strachan D; Timpson P; Munro J; Schröder E; Zhou J; Brunton VG; Barker N; Clevers H; Sansom OJ; Anderson KI; Weaver VM; Olson MF, 2011, 'Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth', Cancer Cell, 19, pp. 776 - 791,
    Journal articles | 2011
    Timpson P; McGhee EJ; Erami Z; Nobis M; Quinn JA; Edward M; Anderson KI, 2011, 'Organotypic collagen I assay: a malleable platform to assess cell behaviour in a 3-dimensional context.', Journal of visualized experiments : JoVE
    Journal articles | 2011
    Timpson P; McGhee EJ; Morton JP; Von Kriegsheim A; Schwarz JP; Karim SA; Doyle B; Quinn JA; Carragher NO; Edward M; Olson MF; Frame MC; Brunton VG; Sansom OJ; Anderson KI, 2011, 'Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53', Cancer Research, 71, pp. 747 - 757,
    Journal articles | 2011
    Timpson P; Mcghee EJ; Anderson KI, 2011, 'Imaging molecular dynamics in vivo - from cell biology to animal models', Journal of Cell Science, 124, pp. 2877 - 2890,
    Journal articles | 2011
    Timpson P; Mcghee EJ; Erami Z; Nobis M; Quinn JA; Edward M; Anderson KI, 2011, 'Organotypic Collagen I Assay: A Malleable Platform to Assess Cell Behaviour in a 3-Dimensional Context', Journal of Visualized Experiments,
    Journal articles | 2010
    Canel M; Serrels A; Miller D; Timpson P; Serrels B; Frame MC; Brunton VG, 2010, 'Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: Effects on e-cadherin dynamics', Cancer Research, 70, pp. 9413 - 9422,
    Journal articles | 2010
    Morton JP; Karim SA; Graham K; Timpson P; Jamieson N; Athineos D; Doyle B; McKay C; Heung MY; Oien KA; Frame MC; Evans TRJ; Sansom OJ; Brunton VG, 2010, 'Dasatinib Inhibits the Development of Metastases in a Mouse Model of Pancreatic Ductal Adenocarcinoma', Gastroenterology, 139, pp. 292 - 303,
    Journal articles | 2010
    Morton JP; Timpson P; Karim SA; Ridgway RA; Athineos D; Doyle B; Jamieson NB; Oien KA; Lowy AM; Brunton VG; Frame MC; Evans TRJ; Sansom OJ, 2010, 'Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer', Proceedings of the National Academy of Sciences of the United States of America, 107, pp. 246 - 251,
    Journal articles | 2009
    Brummer T; Larance M; Abreu MTH; Lyons RJ; Timpson P; Emmerich CH; Fleuren EDG; Lehrbach GM; Schramek D; Guilhaus M; James DE; Daly RJ, 2009, 'The docking protein and proto-oncogene product Gab2 is regulated via a novel negative feedback mechanism mediated by 14-3-3 binding.', Cell communication and signaling : CCS, 7, pp. A12 - A12,
    Journal articles | 2009
    Serreis A; Timpson P; Canel M; Schwarz JP; Carragher NO; Frame MC; Brunton VG; Anderson KI, 2009, 'Real-time study of E-cadherin and membrane dynamics in living animals: Implications for disease modeling and drug development', Cancer Research, 69, pp. 2714 - 2719,
    Journal articles | 2009
    Timpson P; Serrels A; Canel M; Frame MC; Brunton VG; Anderson KI, 2009, 'Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo', Cell Adhesion and Migration, 3,
    Journal articles | 2009
    Timpson P; Serrels A; Canel M; Frame MC; Brunton VG; Anderson KI, 2009, 'Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo.', Cell adhesion & migration, 3, pp. 351 - 354
    Journal articles | 2009
    Vila de Muga S; Timpson P; Cubells L; Evans R; Hayes TE; Rentero C; Hegemann A; Reverter M; Lelschner ; Pol A; Tebar F; Daly RJ; Enrich C; Grewal T, 2009, 'Annexin A6 inhibits Ras signalling in breast cancer cells', Oncogene, 28, pp. 363 - 377,
    Journal articles | 2008
    Brummer T; Larance MC; Abreu M; Lyons RJ; Timpson P; Emmerich C; Fleuren E; Lehrbach GM; Schramek D; Guilhaus M; James DE; Daly RJ, 2008, 'Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein', European Molecular Biology Organization, 27, pp. 2305 - 2316
    Journal articles | 2008
    Llado A; Timpson P; Vila de Muga S; Moreto J; Pol A; Grewal T; Daly RJ; Enrich C; Tebar F, 2008, 'Protein kinase C delta and calmodulin regulate epidermal growth factor receptor recycling from early endosomes through Arp2/3 complex and cortactin', Molecular Biology of the Cell, 19, pp. 17 - 29
    Journal articles | 2007
    Timpson P; Wilson A; Lehrbach GM; Sutherland RL; Musgrove EA; Daly RJ, 2007, 'Aberrant expression of cortactin in head and neck squamous cell carcinoma cells is associated with enhanced cell proliferation and resistance to the epidermal growth factor receptor inhibitor gefitinib', Cancer research, 67, pp. 9304 - 9314
    Journal articles | 2006
    Ardern H; Sandilands E; Machesky LM; Timpson P; Frame MC; Brunton VG, 2006, 'Src-dependent phosphorylation of Scar1 promotes its association with the Arp2/3 complex', Cell Motility and the Cytoskeleton, 63, pp. 6 - 13,
    Journal articles | 2005
    Daly RJ; Timpson P, 2005, 'Distinction at the leading edge of the cell', BioEssays, 27, pp. 349 - 352
    Journal articles | 2005
    Timpson P; Lynch DK; Schramek D; Walker F; Daly RJ, 2005, 'Cortactin overexpression inhibits ligand-induced down-regulation of the epidermal growth factor receptor', Cancer research, 65, pp. 3273 - 3280
    Journal articles | 2004
    Gourlay CW; Carpp LN; Timpson P; Winder SJ; Ayscough KR, 2004, 'A role for the actin cytoskeleton in cell death and aging in yeast', Journal of Cell Biology, 164, pp. 803 - 809,
    Journal articles | 2001
    Timpson P; Jones GE; Frame MC; Brunton VG, 2001, 'Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity', Current Biology, 11, pp. 1836 - 1846,
    Journal articles | 1997
    Chalmers RM; Sturdee AP; Mellors P; Nicholson V; Lawlor F; Kenny F; Timpson P, 1997, 'Cryptosporidium parvum in environmental samples in the Sligo area, Republic of Ireland: A preliminary report', Letters in Applied Microbiology, 25, pp. 380 - 384,
    Journal articles | 1996
    Williams J; Stewart P; Timpson P, 1996, 'Characterization of rainbow trout, Oncorhynchus mykiss (Walbaum), serum creatine kinase isoenzymes and isoforms by means of electrophoresis and isoelectric focusing', Journal of Fish Diseases, 19, pp. 441 - 447,
  • Preprints | 2022
    Ju RJ; Falconer AD; Dean KM; Fiolka RP; Sester DP; Nobis M; Timpson P; Lomakin AJ; Danuser G; White MD; Oelz DB; Haass NK; Stehbens SJ, 2022, Compression-dependent microtubule reinforcement comprises a mechanostat which enables cells to navigate confined environments, ,
    Preprints | 2021
    Dawson JC; Munro A; Macleod K; Muir M; Timpson P; Williams RJ; Frame M; Brunton VG; Carragher NO, 2021, Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors,
    Preprints | 2020
    Ghoroghi S; Mary B; Larnicol A; Klein A; Osmani N; Busnelli I; Delalande F; Paul N; Halary S; Gros F; Fouillen L; Haeberle AM; Royer C; Spiegelhalter C; André-Grégoire G; Murphy K; Timpson P; Carapito R; Blot-Chabaud M; Gavard J; Carapito C; Vitale N; Lefebvre O; Goetz JG; Hyenne V, 2020, Ral GTPases promote metastasis by controlling biogenesis and organ colonization of exosomes,
    Preprints | 2020
    Sharbeen G; McCarroll JA; Akerman A; Kopecky C; Youkhana J; Holst J; Boyer C; Erkan M; Goldstein D; Timpson P; Cox TR; Pereira BA; Chitty JL; Fey S; Najumudeen AK; Campbell AD; Sansom OJ; Ignacio RMC; Naim S; Liu J; Russia N; Lee J; Chou A; Johns A; Gill A; Gonzales-Aloy E; Kokkinos J; Gebski V; Turner N; Apte M; Davis TP; Morton JP; Haghighi K; Phillips PA, 2020, Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma determine response to SLC7A11 inhibition,
    Conference Papers | 2019
    Pinho AV; Van Bulck M; Chantrill L; Arshi M; Herrmann D; Vennin C, 2019, 'ROBO2 is a stroma suppressor gene in the pancreas through regulation of TGF-beta', in CANCER IMMUNOLOGY RESEARCH, AMER ASSOC CANCER RESEARCH,
    Conference Abstracts | 2018
    Pinho AV; Bulck MV; Chantrill L; Arshi M; Sklyarova T; Herrmann D; Vennin C; Gallego-Ortega D; Mawson A; Giry-Laterriere M; Magenau A; Baeyens L; Gill AJ; Phillips P; Timpson P; Biankin AV; Wu J; Rooman I, 2018, 'ROBO2 is a Stroma Suppressor Gene in the Pancreas Through Regulation of TGF-beta', in PANCREAS, LIPPINCOTT WILLIAMS & WILKINS, Vol. 47, pp. 1417 - 1417,
    Conference Papers | 2018
    Warren SC; Magenau A; Nobis M; Herrmann D; Mélénec P; Anderson KI; Sansom OJ; Morton JP; Welch HC; Timpson P, 2018, 'Unmixing spectrally overlapping FRET biosensors in vivo using multispectral FLIM (Conference Presentation)', in Periasamy A; So PT; Xie XS; König K (eds.), Multiphoton Microscopy in the Biomedical Sciences XVIII, SPIE, pp. 23 - 23, presented at Multiphoton Microscopy in the Biomedical Sciences XVIII, 27 January 2018 - 01 February 2018,
    Preprints | 2017
    Cazet A; Hui M; Elsworth B; Wu S; Roden D; Chan C-L; Skhinas J; Collot R; Yang J; Harvey K; Johan Z; Cooper C; Nair R; Herrmann D; McFarland A; Deng N-T; Ruiz-Borrego M; Rojo F; Trigo J; Bezares S; Caballero R; Lim E; Timpson P; O’Toole S; Watkins N; Cox T; Samuel M; Martín M; Swarbrick A, 2017, Targeting stromal remodeling and cancer stem cell plasticity to overcome chemoresistance in triple negative breast cancer,
    Conference Abstracts | 2017
    Chin VT; Nagrial A; Conway J; Vennin C; Chantrill LA; Chou A; Steinmann A; Gill AJ; Humprhis J; Drury A; Froio D; Morgan A; Biankin A; Timpson P; Pajic M, 2017, 'Effect of Rho/ROCK pathway inhibition on metastasis-free and overall survival in biomarker selected, orthotopic, patient-derived models of pancreatic cancer.', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, IL, Chicago, Vol. 35, presented at 53rd Annual Clinical Science Meeting of the American-Society-of-Clinical-Oncology (ASCO) / Symposium on Old Targets, New Drugs - Her2 and MET, IL, Chicago, 02 June 2017 - 07 June 2017,
    Conference Abstracts | 2016
    Huo CW; Chew G; Waltham M; Ingman W; Brown K; Timpson P; Khoo C; Fox S; Hill P; Chen S; Price J; Nguyen CH; Williams ED; Henderson M; Thompson EW; Britt K, 2016, 'THE BIOLOGY UNDERLYING MAMMOGRAPHIC DENSITY AND PRECLINICAL MOUSE MODELS TO TEST NEW THERAPIES', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, Vol. 12, pp. 100 - 101,
    Conference Abstracts | 2015
    Chin VT; Conway J; Nagrial A; Chantrill LA; Chou A; Steinmann A; Gill A; Pinese M; Wu J; Johns A; Dury A; Biankin A; Timpson P; Pajic M, 2015, 'Targeting the Rho-ROCK pathway to treat pancreatic cancer: The use of unique preclinical models to ascertain the effects on cancer growth and metastasis', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, CA, San Francisco, Vol. 33, presented at Gastrointestinal Cancers Symposium, CA, San Francisco, 15 January 2015 - 17 January 2015,
    Conference Abstracts | 2015
    Ooms LM; Binge LC; Rahman P; Conway JR; Ferguson DT; Fedele CG; Gurung R; Vieusseux JL; Chai RC; Price JT; Tiganis T; Timpson P; McLean CA; Mitchell CA, 2015, 'REGULATION OF PI3K/AKT-DEPENDENT BREAST CANCER GROWTH AND METASTASIS', in JOURNAL OF GENE MEDICINE, WILEY-BLACKWELL, AUSTRALIA, Univ Melbourne, Univ Coll, Parkville, Vol. 17, pp. 177 - 178, presented at 9th Biennial Meeting of the Australasian-Gene-and-Cell-Therapy-Society (AGCTS), AUSTRALIA, Univ Melbourne, Univ Coll, Parkville, 29 April 2015 - 01 May 2015,
    Conference Presentations | 2014
    Chou A; Chin VT; Nagrial AM; Gill AJ; Timpson P; Chang DK; Waddell N; Wu J; Grimmond SM; Biankin AV; Pajic M, 2014, 'From functional genomics to precision medicine: Using well annotated models to define personalised treatment strategies for pancreatic cancer', Vol. 34, pp. S8 - S8,
    Conference Abstracts | 2014
    Macpherson IR; Rainero E; van den Berghe PVE; Speirs C; Dozynkiewicz MA; Chaudhary S; Kalna G; Edwards J; Timpson P; Norman JC, 2014, 'CLIC3 controls delivery of late endosomal MT1-MMP to the ventral plasma membrane and dictates invasion and metastasis in estrogen receptor-negative breast cancer', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, SCOTLAND, Glasgow, Vol. 50, pp. S112 - S112, presented at 9th European Breast Cancer Conference (EBCC), SCOTLAND, Glasgow, 19 March 2014 - 21 March 2014,
    Conference Posters | 2013
    Chin V; Nagrial A; Chang D; Chantrill L; Cowley M; Wu J; Spielman C; Steinmann A; Pinese M; Pettitt J; Johns A; Gill A; Timpson P; Biankin A; Pajic M, 2013, 'From function genomics to precision medicine: the therapeutic potential of targeting rock signalling in pancreatic cancer', Chicago, IL, Vol. 9, pp. 53 - 53, presented at ASCO Annual Meeting, Chicago, IL, 31 May 2013 - 04 June 2013,
    Conference Abstracts | 2013
    Chin VT; Nagrial A; Chantrill LA; Chang DK; Chou A; Humprhis J; Cowley M; Wu J; DiPetro R; Watson C; Spielman C; Steinmann A; Pinese M; Pettitt J; Johns A; Waddell N; Grimmond S; Timpson P; Biankin AV; Pajic M, 2013, 'From functional genomics to precision medicine: The therapeutic potential of targeting ROCK signaling in pancreatic cancer.', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, IL, Chicago, Vol. 31, presented at 49th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), IL, Chicago, 31 May 2013 - 04 June 2013,
    Conference Abstracts | 2012
    Doyle B; Tan EH; Timpson P; Machesky LM; Ridgway RR; Jeffery RR; Poulsom B; Morton JP; Sansom OJ, 2012, 'The Tumor Suppressor ARF Can Promote Invasion in the Absence of p53 Activity', in MODERN PATHOLOGY, NATURE PUBLISHING GROUP, CANADA, Vancouver, Vol. 25, pp. 461A - 461A, presented at 101st Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology, CANADA, Vancouver, 17 March 2012 - 23 March 2012,
    Conference Abstracts | 2012
    Doyle B; Tan EH; Timpson P; Machesky LM; Ridgway RR; Jeffrey RR; Poulsom R; Morton JP; Sansom OJ, 2012, 'The Tumor Suppressor ARF Can Promote Invasion in the Absence of p53 Activity', in LABORATORY INVESTIGATION, NATURE PUBLISHING GROUP, CANADA, Vancouver, Vol. 92, pp. 461A - 461A, presented at 101st Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP), CANADA, Vancouver, 17 March 2012 - 23 March 2012,
    Conference Abstracts | 2011
    Doyle B; Tan EH; Timpson P; Machesky LM; Ridgway RA; Jeffery RE; Poulsom R; Morton JP; Sansom OJ, 2011, 'The Tumour Suppressor ARF Can Promote Invasion in a p53 Null Setting', in JOURNAL OF PATHOLOGY, WILEY-BLACKWELL, ENGLAND, Univ Cambridge, Dept Pathol, Cambridge, Vol. 224, pp. S3 - S3, presented at 199th Scientific Meeting of the Pathological-Society-of-Great-Britain-and-Ireland, ENGLAND, Univ Cambridge, Dept Pathol, Cambridge, 06 January 2011 - 07 January 2011,
    Conference Papers | 2011
    Lindsay CR; Lawn S; Campbell A; Faller W; Rambow F; Mort R; Timpson P; Li A; Cammareri P; Rafferty M; Murphy I; McDermott E; Sheahan K; Gallacher W; Van Kempen L; Beermann F; Der C; Larue L; Welch H; Ozanne B; Sansom O, 2011, 'Abstract B147: P-Rex1 is required for efficient melanoma metastasis.', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), pp. B147 - B147, presented at Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 12-16, 2011; San Francisco, CA,
    Conference Papers | 2009
    Brunton VG; Serrels A; Timpson P; Canel M; Frame MC; Anderson KI, 2009, 'real-time study of E-cadherin dynamics in live animals using photo-activation and -bleaching', in CLINICAL & EXPERIMENTAL METASTASIS, SPRINGER, pp. 909 - 909,
    Conference Papers | 2001
    Brunton VG; Timpson P; Carragher NO; Machesky L; Frame MC, 2001, 'Association of Scar with the Src tyrosine kinase consequences for Scar regulation', in BRITISH JOURNAL OF CANCER, CHURCHILL LIVINGSTONE, pp. 22 - 22,
    Preprints |
    Boslem E; Riebe S; Smeuninx B; Egan CL; Tegegne S; McLennan E; Nobis M; Mu A; Nowell CJ; Horadagoda N; Mellet NA; Carlessi R; Timpson P; Tirnitz-Parker JEE; Meikle PJ; Rose-John S; Karin M; Febbraio MA, Therapeutic Blockade of ER Stress and Inflammation Prevents High Fat Diet-Induced NASH and Progression to Hepatocellular Carcinoma, ,
    Preprints |
    Valdes-Mora F; Salomon R; Gloss B; Law AMK; Castillo L; Murphy K; Venhuizen J; Magenau A; Papanicolau M; Rodriguez de la Fuente L; Roden DL; Colino-Sanguino Y; Kikhtyak Z; Farbehi N; Conway JRW; Oakes SR; Sikta N; O'Donoghue SI; Cox TR; Timpson P; Ormandy CJ; Gallego Ortega D, Single Cell Transcriptomics Reveals Involution Mimicry During the Specification of the Basal Breast Cancer Subtype,