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Dr Neil Youngson

Dr Neil Youngson

Adjunct Senior Lecturer
Medicine & Health
School of Biomedical Sciences

Dr Youngson’s main scientific interest has been in non-Mendelian mechanisms of phenotype transmission in mammals and the evolutionary and health implications of these phenomena. He completed his PhD with Professor Anne Ferguson-Smith at Cambridge University U.K. in 2005. From 2006-2012 he did research in the group of Professor Emma Whitelaw at the Queensland Institute of Medical Research, Brisbane. In both of these laboratories Dr Youngson worked on mouse models of non-genetic inheritance, making discoveries in how epigenetic molecules can be inherited between generations to influence the phenotype of offspring. With his move to UNSW in 2012 to the lab of Professor Margaret Morris his expertise is now being applied to rodent models of human disease, in particular obesity. It has long been known that whether an individual develops obesity or not is due to complex interactions between the environment (such as diet and exercise) and the genome. However, recent evidence from the Morris Laboratory in the School of Medical Sciences, and others has shown that the life-time experiences of an individual’s mother and father also influence the risk of developing obesity. This discovery is especially interesting as it suggests that what we inherit from our parents is more than just DNA, and that extra factor can cause disease. Currently the best explanation for these phenomena is the involvement of epigenetic molecules which can be transferred between generations and can persist for the life-time of an individual. Understanding the role of epigenetic molecules in obesity is an exciting new area for disease research and is likely to provide new avenues for therapeutic innovation.

Phone
+61 2 9385 3209
Location
Department of Pharmacology School of Medical Sciences, UNSW Medicine, The University of New South Wales, Sydney, NSW 2052 Australia
  • Journal articles | 2024
    Newton AH; Hutchison JC; Farley ER; Scicluna EL; Youngson NA; Liu J; Menzies BR; Hildebrandt TB; Lawrence BM; Sutherland AHW; Potter DL; Tarulli GA; Selwood L; Frankenberg S; Ord S; Pask AJ, 2024, 'Embryology of the fat-tailed dunnart (Sminthopsis crassicaudata): A marsupial model for comparative mammalian developmental and evolutionary biology', Developmental Dynamics,
    Journal articles | 2024
    Oberin R; Petautschnig S; Jarred EG; Qu Z; Tsai T; Youngson NA; Pulsoni G; Truong TT; Fernando D; Bildsoe H; Blücher RO; van den Buuse M; Gardner DK; Sims NA; Adelson DL; Western PS, 2024, 'Fetal growth delay caused by loss of non-canonical imprinting is resolved late in pregnancy and culminates in offspring overgrowth', eLife, 13,
    Journal articles | 2024
    Yao S; Prates K; Freydenzon A; Assante G; McRae AF; Morris MJ; Youngson NA, 2024, 'Liver-specific deletion of de novo DNA methyltransferases protects against glucose intolerance in high-fat diet-fed male mice', FASEB Journal, 38,
    Journal articles | 2024
    Yu J; Youngson NA; Laybutt DR; Morris MJ; Leigh SJ, 2024, 'Complementary yet divergent effects of exercise and an exercise mimetic on microbiome in high-fat diet-induced obesity', Physiological Genomics, 56, pp. 136 - 144,
    Journal articles | 2023
    Assante G; Chandrasekaran S; Ng S; Tourna A; Chung CH; Isse KA; Banks JL; Soffientini U; Filippi C; Dhawan A; Liu M; Rozen SG; Hoare M; Campbell P; Ballard JWO; Turner N; Morris MJ; Chokshi S; Youngson NA, 2023, 'Correction: Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease (Genome Medicine, (2022), 14, 1, (67), 10.1186/s13073-022-01071-5)', Genome Medicine, 15,
    Journal articles | 2023
    Cherubini A; Ostadreza M; Jamialahmadi O; Pelusi S; Rrapaj E; Casirati E; Passignani G; Norouziesfahani M; Sinopoli E; Baselli G; Meda C; Dongiovanni P; Dondossola D; Youngson N; Tourna A; Chokshi S; Bugianesi E; Ronzoni L; Bianco C; Cerami L; Torcianti V; Periti G; Margarita S; Carpani R; Malvestiti F; Marini I; Tomasi M; Lombardi A; Rondena J; Maggioni M; D’Ambrosio R; Vaira V; Fracanzani AL; Rosso C; Pennisi G; Petta S; Liguori A; Miele L; Tavaglione F; Vespasiani-Gentilucci U; Dallio M; Federico A; Soardo G; Pihlajamäki J; Männistö V; Della Torre S; Prati D; Romeo S; Valenti L, 2023, 'Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women', Nature Medicine, 29, pp. 2643 - 2655,
    Journal articles | 2023
    Stamouli M; Konstantinou C; Jeyanesan D; Wright J; Elliott Z; Dwarampudi S; Zamalloa A; Youngson N; Patel VC; Hadjihambi A, 2023, 'P7 Plasma Neurofilament Light Chain as a Novel Potential Biomarker for the Stratification and Risk Profiling of Hepatic Encephalopathy in Cirrhosis', American Journal of Gastroenterology, 118, pp. S6 - S7,
    Journal articles | 2023
    Weinberg-Shukron A; Youngson NA; Ferguson-Smith AC; Edwards CA, 2023, 'Epigenetic control and genomic imprinting dynamics of the Dlk1-Dio3 domain', Frontiers in Cell and Developmental Biology, 11,
    Journal articles | 2023
    Wu LE; Fiveash CE; Bentley NL; Kang MJ; Govindaraju H; Barbour JA; Wilkins BP; Hancock SE; Madawala R; Das A; Massudi H; Li C; Kim LJ; Wong ASA; Marinova MB; Sultani G; Das A; Youngson NA; Le Couteur DG; Sinclair DA; Turner N, 2023, 'SIRT2 transgenic over-expression does not impact lifespan in mice', Aging Cell, 22,
    Journal articles | 2023
    da Rocha ST; Lin SP; Youngson NA, 2023, 'Editorial: Legacies of epigenetic perturbations', Frontiers in Cell and Developmental Biology, 11,
    Journal articles | 2022
    Assante G; Chandrasekaran S; Ng S; Tourna A; Chung CH; Isse KA; Banks JL; Soffientini U; Filippi C; Dhawan A; Liu M; Rozen SG; Hoare M; Campbell P; Ballard JWO; Turner N; Morris MJ; Chokshi S; Youngson NA, 2022, 'Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease', Genome Medicine, 14,
    Journal articles | 2022
    Assante G; Tourna A; Carpani R; Ferrari F; Prati D; Peyvandi F; Blasi F; Bandera A; Le Guennec A; Chokshi S; Patel VC; Cox IJ; Valenti L; Youngson NA, 2022, 'Reduced circulating FABP2 in patients with moderate to severe COVID-19 may indicate enterocyte functional change rather than cell death', Scientific Reports, 12,
    Journal articles | 2022
    Towarnicki SG; Youngson NA; Corley SM; St. John JC; Melvin RG; Turner N; Morris MJ; Ballard JWO, 2022, 'Ancestral dietary change alters the development of Drosophila larvae through MAPK signalling', Fly, 16, pp. 299 - 311,
    Journal articles | 2022
    Yamashita H; Tourna A; Akita M; Itoh T; Chokshi S; Ajiki T; Fukumoto T; Youngson NA; Zen Y, 2022, 'Epigenetic upregulation of TET2 is an independent poor prognostic factor for intrahepatic cholangiocarcinoma', Virchows Archiv, 480, pp. 1077 - 1085,
    Journal articles | 2022
    Youngson N, 2022, 'The relationships between retrotransposons and local and genome-wide epigenetic state', TOXICOLOGY LETTERS, 368, pp. S40 - S41,
    Journal articles | 2022
    Youngson NA; Castino MR; Stuart A; Kershaw KA; Holmes NM; Heffernan EC; Waters PD; Morris KV; Clemens KJ, 2022, 'A role for a novel natural antisense-BDNF in the maintenance of nicotine-seeking', Addiction Neuroscience, 2,
    Journal articles | 2022
    Yu J; Laybutt DR; Youngson NA; Morris MJ, 2022, 'Concurrent betaine administration enhances exercise-induced improvements to glucose handling in obese mice', Nutrition, Metabolism and Cardiovascular Diseases, 32, pp. 2439 - 2449,
    Journal articles | 2021
    Assante G; Williams R; Youngson NA, 2021, 'Is the increased risk for MAFLD patients to develop severe COVID-19 linked to perturbation of the gut-liver axis?', Journal of Hepatology, 74, pp. 487 - 488,
    Journal articles | 2021
    Yu J; Laybutt DR; Kim LJ; Quek LE; Wu LE; Morris MJ; Youngson NA, 2021, 'Exercise-induced benefits on glucose handling in a model of diet-induced obesity are reduced by concurrent nicotinamide mononucleotide', American Journal of Physiology - Endocrinology and Metabolism, 321, pp. E176 - E189,
    Journal articles | 2020
    Bertoldo MJ; Listijono DR; Ho WHJ; Riepsamen AH; Goss DM; Richani D; Jin XL; Mahbub S; Campbell JM; Habibalahi A; Loh WGN; Youngson NA; Maniam J; Wong ASA; Selesniemi K; Bustamante S; Li C; Zhao Y; Marinova MB; Kim LJ; Lau L; Wu RM; Mikolaizak AS; Araki T; Le Couteur DG; Turner N; Morris MJ; Walters KA; Goldys E; O'Neill C; Gilchrist RB; Sinclair DA; Homer HA; Wu LE, 2020, 'NAD+ Repletion Rescues Female Fertility during Reproductive Aging', Cell Reports, 30, pp. 1670 - 1681.e7,
    Journal articles | 2020
    Campit SE; Meliki A; Youngson NA; Chandrasekaran S, 2020, 'Nutrient Sensing by Histone Marks: Reading the Metabolic Histone Code Using Tracing, Omics, and Modeling', BioEssays, 42,
    Journal articles | 2020
    Cespiati A; Youngson NA; Tourna A; Valenti L, 2020, 'Genetics and epigenetics in the clinic: Precision medicine in the management of fatty liver disease', Current Pharmaceutical Design, 26, pp. 998 - 1009,
    Journal articles | 2020
    Morris MJ; Hesson LB; Youngson NA, 2020, 'Non-CpG methylation biases bisulphite PCR towards low or unmethylated mitochondrial DNA: recommendations for the field', Environmental Epigenetics, 6,
    Journal articles | 2020
    Uddin GM; Youngson NA; Chowdhury SS; Hagan C; Sinclair DA; Morris MJ, 2020, 'Administration of nicotinamide mononucleotide (NMN) reduces metabolic impairment in male mouse offspring from obese mothers', Cells, 9,
    Journal articles | 2020
    Yu J; Laybutt DR; Kim L-J; Quek L-E; Wu LE; Morris MJ; Youngson NA, 2020, 'EXERCISE-INDUCED BENEFITS ON GLUCOSE HANDLING IN A MODEL OF DIET-INDUCED OBESITY ARE REDUCED BY CONCURRENT NICOTINAMIDE MONONUCLEOTIDE', , pp. 2020.06.22.164459,
    Journal articles | 2019
    Bajracharya R; Youngson NA; Ballard JWO, 2019, 'Dietary macronutrient management to treat mitochondrial dysfunction in parkinson’s disease', International Journal of Molecular Sciences, 20,
    Journal articles | 2019
    Youngson NA; Mezbah Uddin G; Das A; Martinez C; Connaughton HS; Whiting S; Yu J; Sinclair DA; John Aitken R; Morris MJ, 2019, 'Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice', Reproduction, 158, pp. 169 - 179,
    Journal articles | 2019
    Zieba J; Uddin GM; Youngson NA; Karl T; Morris MJ, 2019, 'Long-term behavioural effects of maternal obesity in C57BL/6J mice', Physiology and Behavior, 199, pp. 306 - 313,
    Journal articles | 2018
    Aw WC; Towarnicki SG; Melvin RG; Youngson NA; Garvin MR; Hu Y; Nielsen S; Thomas T; Pickford R; Bustamante S; Vila-Sanjurjo A; Smyth GK; Ballard JWO, 2018, 'Genotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness', PLoS Genetics, 14,
    Journal articles | 2018
    Bertoldo MJ; Uddin GM; Youngson NA; Agapiou D; Walters KA; Sinclair DA; Morris MJ; Gilchrist RB, 2018, 'Multigenerational obesity-induced perturbations in oocyte-secreted factor signalling can be ameliorated by exercise and nicotinamide mononucleotide.', Hum Reprod Open, 2018, pp. hoy010 - hoy010,
    Journal articles | 2018
    Castino MR; Baker-Andresen D; Ratnu VS; Shevchenko G; Morris KV; Bredy TW; Youngson NA; Clemens KJ, 2018, 'Persistent histone modifications at the BDNF and Cdk-5 promoters following extinction of nicotine-seeking in rats', Genes, Brain and Behavior, 17, pp. 98 - 106,
    Journal articles | 2018
    Gokarn R; Solon-Biet S; Youngson NA; Wahl D; Cogger VC; McMahon AC; Cooney GJ; Ballard JWO; Raubenheimer D; Morris MJ; Simpson SJ; Le Couteur DG, 2018, 'The Relationship between Dietary Macronutrients and Hepatic Telomere Length in Aging Mice', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 73, pp. 446 - 449,
    Journal articles | 2018
    Hsu CL; Chou CH; Huang SC; Lin CY; Lin MY; Tung CC; Lin CY; Lai IP; Zou YF; Youngson NA; Lin SP; Yang CH; Chen SK; Gau SSF; Huang HS, 2018, 'Analysis of experience-regulated transcriptome and imprintome during critical periods of mouse visual system development reveals spatiotemporal dynamics', Human Molecular Genetics, 27, pp. 1039 - 1054,
    Journal articles | 2018
    Morris MJ; Hesson LB; Poulos RC; Ward RL; Wong JWH; Youngson NA, 2018, 'Reduced nuclear DNA methylation and mitochondrial transcript changes in adenomas do not associate with mtDNA methylation', Biomarker Research, 6,
    Journal articles | 2017
    Uddin GM; Youngson NA; Doyle BM; Sinclair DA; Morris MJ, 2017, 'Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: Comparison with exercise', Scientific Reports, 7, pp. 15063,
    Journal articles | 2017
    Youngson NA; Morris MJ; Ballard B, 2017, 'The mechanisms mediating the antiepileptic effects of the ketogenic diet, and potential opportunities for improvement with metabolism-altering drugs', Seizure, 52, pp. 15 - 19,
    Journal articles | 2016
    Daxinger L; Oey H; Isbel L; Whitelaw NC; Youngson NA; Spurling A; Vonk KKD; Whitelaw E, 2016, 'Hypomethylation of ERVs in the sperm of mice haploinsufficient for the histone methyltransferase Setdb1 correlates with a paternal effect on phenotype', Scientific Reports, 6,
    Journal articles | 2016
    Maniam J; Antoniadis CP; Youngson NA; Sinha JK; Morris MJ, 2016, 'Sugar Consumption Produces Effects Similar to Early Life Stress Exposure on Hippocampal Markers of Neurogenesis and Stress Response', FRONTIERS IN MOLECULAR NEUROSCIENCE, 8,
    Journal articles | 2016
    Maniam J; Antoniadis CP; Youngson NA; Sinha JK; Morris MJ, 2016, 'Sugar consumption produces effects similar to early life stress exposure on hippocampal markers of neurogenesis and stress response', Frontiers in Molecular Neuroscience, 8,
    Journal articles | 2016
    Uddin GM; Youngson NA; Sinclair DA; Morris MJ, 2016, 'Head to head comparison of short-term treatment with the NAD+ precursor nicotinamide mononucleotide (NMN) and 6 weeks of exercise in obese female mice', Frontiers in Pharmacology, 7, pp. 258,
    Journal articles | 2016
    Youngson N; Lecomte V; Maloney C; Leung P; Liu J; Hesson L; Luciani F; Krause L; Morris M; Liu JJ, 2016, 'Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring', Asian Journal of Andrology, 18, pp. 930 - 936,
    Journal articles | 2015
    Crean AJ; Youngson NA, 2015, 'Both negative and positive data are needed for understanding non-genetic inheritance', Non-Genetic Inheritance, 2,
    Journal articles | 2015
    O. Ballard JW; Youngson NA, 2015, 'Review: Can diet influence the selective advantage of mitochondrial DNA haplotypes?', Bioscience Reports, 35,
    Journal articles | 2014
    Ng SF; Lin RCY; Maloney CA; Youngson NA; Owens JA; Morris MJ, 2014, 'Paternal high-fat diet consumption induces common changes in the transcriptomes of retroperitoneal adipose and pancreatic islet tissues in female rat offspring', FASEB Journal, 28, pp. 1830 - 1841,
    Journal articles | 2013
    Lecomte V; Youngson NA; Maloney CA; Morris MJ, 2013, 'Parental programming: How can we improve study design to discern the molecular mechanisms?', BioEssays, 35, pp. 787 - 793,
    Journal articles | 2013
    Nelson AC; Cauceglia JW; Merkley SD; Youngson NA; Oler AJ; Nelson RJ; Cairns BR; Whitelaw E; Potts WK, 2013, 'Reintroducing domesticated wild mice to sociality induces adaptive transgenerational effects on MUP expression', Proceedings of the National Academy of Sciences of the United States of America, 110, pp. 19848 - 19853,
    Journal articles | 2013
    Reddington JP; Perricone SM; Nestor CE; Reichmann J; Youngson NA; Suzuki M; Reinhardt D; Dunican DS; Prendergast JG; Mjoseng H; Ramsahoye BH; Whitelaw E; Greally JM; Adams IR; Bickmore WA; Meehan RR, 2013, 'Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes', Genome Biology, 14,
    Journal articles | 2013
    Youngson NA; Epp T; Roberts AR; Daxinger L; Ashe A; Huang E; Lester KL; Harten SK; Kay GF; Cox T; Matthews JM; Chong S; Whitelaw E, 2013, 'No evidence for cumulative effects in a Dnmt3b hypomorph across multiple generations', Mammalian Genome, 24, pp. 206 - 217,
    Journal articles | 2013
    Youngson NA; Lin P-C; Lin S-S, 2013, 'The convergence of autophagy, small RNA and the stress response – implications for transgenerational epigenetic inheritance in plants', BioMolecular Concepts, 5, pp. 1 - 8,
    Journal articles | 2012
    Youngson NA, 2012, 'Challenges and future prospects for non-genetic inheritance', Non-Genetic Inheritance, 1, pp. 1 - 8,
    Journal articles | 2011
    Oey HM; Youngson NA; Whitelaw E, 2011, 'The characterisation of piRNA-related 19mers in the mouse', BMC Genomics, 12,
    Journal articles | 2011
    Roberts AR; Blewitt ME; Youngson NA; Whitelaw E; Chong S, 2011, 'Reduced dosage of the modifiers of epigenetic reprogramming Dnmt1, Dnmt3L, SmcHD1 and Foxo3a has no detectable effect on mouse telomere length in vivo', Chromosoma, 120, pp. 377 - 385,
    Journal articles | 2011
    Youngson NA; Chong S; Whitelaw E, 2011, 'Gene silencing is an ancient means of producing multiple phenotypes from the same genotype: Common mechanisms and functions in epigenetic processes can be seen throughout all life forms', BioEssays, 33, pp. 95 - 99,
    Journal articles | 2011
    Youngson NA; Vickaryous N; Van Der Horst A; Epp T; Harten S; Fleming JS; Khanna KK; De Kretser DM; Whitelaw E, 2011, 'A missense mutation in the transcription factor Foxo3a causes teratomas and oocyte abnormalities in mice', Mammalian Genome, 22, pp. 235 - 248,
    Journal articles | 2011
    Youngson NA; Whitelaw E, 2011, 'The effects of acquired paternal obesity on the next generation', Asian Journal of Andrology, 13, pp. 195 - 196,
    Journal articles | 2009
    Tierling S; Gasparoni G; Youngson N; Paulsen M, 2009, 'The Begain gene marks the centromeric boundary of the imprinted region on mouse chromosome 12', Mammalian Genome, 20, pp. 699 - 710,
    Journal articles | 2008
    Li X; Ito M; Zhou F; Youngson N; Zuo X; Leder P; Ferguson-Smith AC, 2008, 'A Maternal-Zygotic Effect Gene, Zfp57, Maintains Both Maternal and Paternal Imprints', Developmental Cell, 15, pp. 547 - 557,
    Journal articles | 2008
    Youngson NA; Whitelaw E, 2008, 'Transgenerational epigenetic effects', Annual Review of Genomics and Human Genetics, 9, pp. 233 - 257,
    Journal articles | 2007
    Chong S; Vickaryous N; Ashe A; Zamudio N; Youngson N; Hemley S; Stopka T; Skoultchi A; Matthews J; Scott HS; De Kretser D; O'Bryan M; Blewitt M; Whitelaw E, 2007, 'Modifiers of epigenetic reprogramming show paternal effects in the mouse', Nature Genetics, 39, pp. 614 - 622,
    Journal articles | 2007
    Chong S; Youngson NA; Whitelaw E, 2007, 'Heritable germline epimutation is not the same as transgenerational epigenetic inheritance [5]', Nature Genetics, 39, pp. 574 - 575,
    Journal articles | 2005
    Youngson NA; Kocialkowski S; Peel N; Ferguson-Smith AC, 2005, 'A small family of sushi-class retrotransposon-derived genes in mammals and their relation to genomic imprinting', Journal of Molecular Evolution, 61, pp. 481 - 490,
    Journal articles | 2004
    Cavaille J; Seitz H; Royo HLN; Lin * S-P; Youngson * N; Ferguson-Smith * AC, 2004, 'Imprinted microRNA genes at the mouse Dlk1-GTl2 domain.', GBM Annual Fall meeting M�nster 2004, 2004,
    Journal articles | 2004
    Ferguson-Smith AC; Lin SP; Youngson N, 2004, 'Regulation of Gene Activity and Repression: A Consideration of Unifying Themes', Current Topics in Developmental Biology, 60, pp. 197 - 213,
    Journal articles | 2004
    Seitz H; Royo H; Lin SP; Youngson N; Ferguson-Smith AC; Cavaillé J, 2004, 'Imprinted small RNA genes', Biological Chemistry, 385, pp. 905 - 911,
    Journal articles | 2003
    Ferguson-Smith A; Lin SP; Tsai CE; Youngson N; Tevendale M, 2003, 'Genomic imprinting - Insights from studies in mice', Seminars in Cell and Developmental Biology, 14, pp. 43 - 49,
    Journal articles | 2003
    Lin SP; Youngson N; Takada S; Seitz H; Reik W; Paulsen M; Cavaille J; Ferguson-Smith AC, 2003, 'Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12', Nature Genetics, 35, pp. 97 - 102,
    Journal articles | 2003
    Seitz H; Youngson N; Lin SP; Dalbert S; Paulsen M; Bachellerie JP; Ferguson-Smith AC; Cavaillé J, 2003, 'Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene', Nature Genetics, 34, pp. 261 - 262,
    Journal articles | 2001
    Paulsen M; Takada S; Youngson NA; Benchaib M; Charlier C; Segers K; Georges M; Ferguson-Smith AC, 2001, 'Comparative sequence analysis of the imprinted Dlk1-Gtl2 locus in three mammalian species reveals highly conserved genomic elements and refines comparison with the Igf2-H19 region', Genome Research, 11, pp. 2085 - 2094,
    Journal articles | 2000
    Meiklejohn DJ; Riches Z; Youngson N; Vicker MA, 2000, 'The contribution of factor VII gene polymorphisms to longevity in Scottish nonagenarians', Thrombosis and Haemostasis, 83, pp. 519,
  • Working Papers | 2020
    Towarnicki S; Youngson NA; Corley S; St John J; Turner N; Morris M; Ballard B, 2020, Ancestral dietary change alters development of Drosophila larvae through MAPK signalling, Cold Spring Harbor, ,
    Working Papers | 2019
    Bertoldo MJ; Listijono DR; Ho W-HJ; Riepsamen AH; Jin XL; Selesniemi K; Goss DM; Mahbub S; Campbell JM; Habibalahi A; Loh W-GN; Youngson NA; Maniam J; Wong ASA; Richani D; Li C; Zhao Y; Marinova M; Kim L-J; Lau L; Wu RM; Mikolaizak AS; Araki T; Le Couteur DG; Turner N; Morris MJ; Walters KA; Goldys E; O’Neill C; Gilchrist RB; Sinclair DA; Homer HA; Wu LE, 2019, NAD+ repletion rescues female fertility during reproductive ageing, Cold Spring Harbor Laboratory,
    Working Papers | 2019
    Youngson NA; Castino MR; Stuart A; Kershaw KA; Holmes NM; Waters PD; Morris KV; Clemens KJ, 2019, A natural antisense to brain-derived neurotrophic factor impairs extinction of drug seeking, Cold Spring Harbor Laboratory,
  • Conference Papers | 2024
    Stamouli M; Konstantinou C; Trovato FM; Wright J; Zamalloa A; Youngson N; McPhail MJW; Hadjihambi A; Patel VC, 2024, 'P34 Alterations in plasma neurofilament light chain in acute and chronic liver failure syndromes', in P34 Alterations in plasma neurofilament light chain in acute and chronic liver failure syndromes, BMJ Publishing Group Ltd and British Society of Gastroenterology, pp. A31.1 - A31, presented at Abstracts of the British Association for the Study of the Liver Annual Meeting, 8–11 October 2024,
    Conference Abstracts | 2022
    Assante G; Chandrasekaran S; Ng S; Tourna A; Chung C; Isse K; Banks J; Soffientini U; Filippi C; Dhawan A; Liu M; Rozen S; Hoare M; Campbell P; Ballard W; Turner N; Morris M; Chokshi S; Youngson N, 2022, 'Acetyl coenzyme A metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY, Vol. 37, pp. 24 - 25,
    Conference Abstracts | 2022
    Illingworth M; Zen Y; Nayagam J; Joshi D; Urbani L; Youngson N; Heaton N; Khorsandi SE, 2022, 'Ribosomal protein encoding genes: potential drivers of primary sclerosing cholangitis associated cholangiocarcinoma', in JOURNAL OF HEPATOLOGY, ELSEVIER, Vol. 77, pp. S650 - S651,
    Preprints | 2022
    Oberin R; Petautschnig S; Tsai T; Jarred EG; Qu Z; Youngson NA; Bildsoe H; Truong TT; Fernando D; van den Buuse M; Gardner DK; Sims NA; Adelson DL; Western PS, 2022, Loss of EED in the oocyte causes initial fetal growth restriction followed by placental hyperplasia and offspring overgrowth,
    Conference Abstracts | 2022
    Stamouli M; Adelmeijer J; Huskens D; Rivera S; O'Reilly K; Palma E; Youngson N; Bernal W; Chokshi S; Roest M; Lisman T; Patel V, 2022, 'Circulating cell-free DNA levels increment with worsening cirrhosis severity and associate with platelet exhaustion and mortality', in JOURNAL OF HEPATOLOGY, ELSEVIER, Vol. 77, pp. S911 - S911,
    Conference Abstracts | 2022
    Stamouli M; Adelmeijer J; Rivera S; O'Reilly K; Palma E; Youngson N; Bernal W; Chokshi S; Lisman T; Patel VC, 2022, 'CIRCULATING MARKERS OF NEUTROPHIL EXTRACELLULAR TRAPS ARE ASSOCIATED WITH EXCESSIVE COAGULATION ACTIVATION IN DECOMPENSATED CIRRHOSIS AND ACUTE-ON-CHRONIC LIVER FAILURE', in GUT, BMJ PUBLISHING GROUP, Vol. 71, pp. A51 - A52,
    Preprints | 2021
    Assante G; Chandrasekaran S; Ng S; Tourna A; Chung C; Isse K; Filippi C; Dhawan A; Liu M; Rozen S; Hoare M; Campbell P; Ballard W; Turner N; Morris M; Chokshi S; Youngson N, 2021, Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease,
    Conference Abstracts | 2021
    Assante G; Tourna A; Chokshi S; Turner N; Ballard JWO; Morris M; Youngson N, 2021, 'Acetyl-CoA metabolism drives epigenome change in liver steatosis leading to widespread abnormal transcription, DNA damage and promotion of hepatocarcinogenetic pathways', in JOURNAL OF HEPATOLOGY, ELSEVIER, Vol. 75, pp. S264 - S265,
    Conference Abstracts | 2021
    Tourna A; Stamouli M; Arefaine B; Baselli GA; Valenti L; Chokshi S; Youngson N; Patel VC, 2021, 'Methylation state of circulating cell-free DNA as a prognostic marker for early to late stage chronic liver disease and acute on chronic liver failure', in JOURNAL OF HEPATOLOGY, ELSEVIER, Vol. 75, pp. S333 - S334,
    Conference Abstracts | 2019
    Yu J; Morris MJ; Youngson NA, 2019, 'Do exercise and NMN provide synergistic benefits in obese mice?', in Obesity Research & Clinical Practice, Elsevier BV, Vol. 13, pp. 299 - 299,
    Conference Abstracts | 2017
    Youngson NA; Lecomte V; Maloney CA; Morris KV; Morris MJ, 2017, 'RNA-SEQUENCING TO DISCOVER NOVEL LONG-NON CODING RNA (LNCRNA) ASSOCIATED WITH OBESITY IN RAT LIVER', in JOURNAL OF GENE MEDICINE, WILEY, AUSTRALIA, Univ Technol Sydney, Sydney, Vol. 20, presented at Joint 10th Annual Scientific Meeting of the Australian-Gene-and-Cell-Therapy-Society (AGCTS) and Australasian-Society-for-Stem-Cell-Research (ASSCR), AUSTRALIA, Univ Technol Sydney, Sydney, 24 May 2017 - 26 May 2017,
    Conference Abstracts | 2015
    Castino M; Youngson N; Baker-Andresen D; Ratnu V; Bredy T; Clemens K, 2015, 'Transcriptional and epigenetic factors underlying the extinction of nicotine-seeking behaviour in the rat', in JOURNAL OF NEUROCHEMISTRY, WILEY-BLACKWELL, AUSTRALIA, Cairns, Vol. 134, pp. 349 - 349, presented at 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, AUSTRALIA, Cairns, 23 August 2015 - 27 August 2015,
    Conference Abstracts | 2015
    Gokarn R; Solon-Biet S; Youngson N; Cogger V; McMahon AC; Morris M; Simpson S; Le Couteur D, 2015, 'Low Dietary Protein to Carbohydrate Ratios Are Linked With Longer Telomere Lengths in Mice', in GERONTOLOGIST, OXFORD UNIV PRESS INC, Vol. 55,
    Conference Abstracts | 2014
    Uddin GM; Youngson N; Sinclair DA; Morris M, 2014, 'Impaired blood glucose clearance and mitochondrial function induced by high fat diet is improved by exercise and an ‘exercise mimetic’', in Obesity Research & Clinical Practice, Elsevier BV, Vol. 8, pp. 108 - 108,
    Conference Abstracts | 2013
    Maloney CA; Lecomte V; Youngson NA; Morris MJ, (ed.), 2013, 'Effects of paternal obesity on F1 female offspring', in Obesity Research & Clinical Practice, Elsevier, Merlbourne, Vol. 7, presented at Australian and New Zeeland Obesity Society (ANZOS) meeting, Merlbourne, 17 October 2013 - 19 October 2013,
    Conference Papers | 2011
    Youngson N; Oey H; Whitelaw E, 2011, 'PATERNAL EFFECTS IN MICE CAUSED BY DICER OR DNMT1 HAPLOINSUFFICIENCY ARE ASSOCIATED WITH CHANGES IN SPERMATOZOAL MIRNA EXPRESSION PROFILE', in JOURNAL OF ANDROLOGY, AMER SOC ANDROLOGY, INC, CANADA, Hyatt Regency Montreal, Montreal, pp. 94 - 95, presented at 36th Annual Meeting of Genes and Harmones - State-of-the-Art Reproductive and Sexual Development, CANADA, Hyatt Regency Montreal, Montreal, 02 April 2011 - 05 April 2011,
    Conference Papers | 2004
    Youngson NA; Kocialowski S; Peel N; Ferguson-Smith AC, 2004, 'A small family of LTR retrotransposon-derived genes in mammals and their relation to genomic imprinting', in GENETICAL RESEARCH, CAMBRIDGE UNIV PRESS, ENGLAND, Univ Coll London, Inst Child Hlth, London, pp. 236 - 236, presented at 15th Genetics-Societys Mammalian Genetics and Development Workshop, ENGLAND, Univ Coll London, Inst Child Hlth, London, 22 November 2004 - 23 November 2004,
    Conference Papers | 1999
    Meiklejohn DJ; Riches Z; Youngson N; Vickers M, 1999, 'The contribution of factor VII (FVII) gene polymorphisms to longevity', in THROMBOSIS AND HAEMOSTASIS, F K SCHATTAUER VERLAG GMBH, pp. 187 - 187,
    Conference Papers | 1999
    Meiklejohn DJ; Riches Z; Youngson N; Vickers M, 1999, 'The contribution of factor VII (FVII) gene polymorphisms to longevity.', in BRITISH JOURNAL OF HAEMATOLOGY, BLACKWELL SCIENCE LTD, pp. 38 - 38,

My Research Supervision

3 PhD Students on projects investigating novel therapeutics for liver disease, and fundamental research into the role of DNA methylation in liver function and body-wide metabolism.