Dr Chris Maloney

Senior Lecturer

BMedSci (Hons 1) usyd: PhD usyd: GradCert ULT Hed UNSW

Medicine & Health

School of Health Sciences

Can nutritional supplementation prevent a rise in the obesity epidemic?
I am currently investigating nutritional approaches to prevent the transmission of effects from an obese parent to the first and second generation thru the supplementation of micronutrients. My research is centred on the ‘fetal programming of adult diseases’ namely Obesity and Diabetes.

The question I am seeking to answer is “How is it that poor Maternal or Paternal nutrition during gestation can permanently alter the developing offspring so that it is predisposed to develop diabetes, obesity and other aspects of the metabolic syndrome”. This has lead me to investigate both, what is it in the diet that can program, and to study epigenetics, in particular DNA methylation as a means of permanently altering gene expression and hence metabolism.

More recently I have focused my research on Paternal Obesity, its effects on fetal programming and transgenerational inheritance.

Broad Research Areas:
Parental and offspring Nutrition, Obesity, Diabetes, Fetal Programming, Micronutrients, Epigenetics

Qualifications:
BMed Sci (Hons 1)��, PhD USyd

Society Memberships & Professional Activities:

Editor The Journal of Nutrition Science (2018-current)

Member of Nutrition Society (2015-current)

Editor The British Journal of Nutrition (2015-2021)
The Australian and New Zealand Obesity Society (Council member, 2009-2015)��
The Nutrition Society of Australia (2009- 2021)

Phone

+61 2 9385 1362

E-mail

c.maloney@unsw.edu.au

Location

Level 2, West Wing, Wallace Wurth Building Exercise Physiology, School of Health Sciences, UNSW Medicine, The University of New South Wales, Sydney, NSW 2052 Australia

Books | 2004

Maloney CA, 2004, Lipid Metabolism in Offspring of Dams Protein Restricted in Pregnancy, School of Molecular and Microbial Biosciences, Faculty of Science, University of Sydney
Journal articles | 2022

Billah MM; Khatiwada S; Lecomte V; Morris MJ; Maloney CA, 2022, 'Ameliorating high-fat diet-induced sperm and testicular oxidative damage by micronutrient-based antioxidant intervention in rats', European Journal of Nutrition, 61, pp. 3741 - 3753,

Journal articles | 2022

Billah MM; Khatiwada S; Morris MJ; Maloney CA, 2022, 'Effects of paternal overnutrition and interventions on future generations', International Journal of Obesity, 46, pp. 901 - 917,

Journal articles | 2021

Khatiwada S; Lecomte V; Fenech MF; Morris MJ; Maloney CA, 2021, 'Effects of micronutrient supplementation on glucose and hepatic lipid metabolism in a rat model of diet induced obesity', Cells, 10, pp. 1751,

Journal articles | 2020

Lederman O; Ward PB; Rosenbaum S; Maloney C; Watkins A; Teasdale S; Morell R; Curtis J, 2020, 'Stepping up early treatment for help-seeking youth with at-risk mental states: Feasibility and acceptability of a real-world exercise program', Early Intervention in Psychiatry, 14, pp. 450 - 462,

Journal articles | 2019

Lederman O; Ward PB; Firth J; Maloney C; Carney R; Vancampfort D; Stubbs B; Kalucy M; Rosenbaum S, 2019, 'Does exercise improve sleep quality in individuals with mental illness? A systematic review and meta-analysis', Journal of Psychiatric Research, 109, pp. 96 - 106,

Journal articles | 2017

Kaakoush NO; Lecomte V; Maloney CA; Morris MJ, 2017, 'Cross-talk among metabolic parameters, esophageal microbiota, and host gene expression following chronic exposure to an obesogenic diet', Scientific Reports, 7, pp. 45753,

Journal articles | 2017

Lecomte V; Maloney CA; Wang KW; Morris MJ, 2017, 'Effects of paternal obesity on growth and adiposity of male rat offspring', American Journal of Physiology - Endocrinology and Metabolism, 312, pp. E117 - E125,

Journal articles | 2017

Lederman O; Rosenbaum S; Maloney C; Curtis J; Ward PB, 2017, 'Modifiable cardiometabolic risk factors in youth with at-risk mental states: A cross-sectional pilot study', Psychiatry Research, 257, pp. 424 - 430,

Journal articles | 2016

Chowdhury SS; Lecomte V; Erlich JH; Maloney CA; Morris MJ, 2016, 'Paternal high fat diet in rats leads to renal accumulation of lipid and tubular changes in adult offspring', Nutrients, 8, pp. 521,

Journal articles | 2016

Dickinson H; Moss TJ; Gatford KL; Moritz KM; Akison L; Fullston T; Hryciw DH; Maloney CA; Morris MJ; Wooldridge AL; Schjenken JE; Robertson SA; Waddell BJ; Mark PJ; Wyrwoll CS; Ellery SJ; Thornburg KL; Muhlhausler BS; Morrison JL, 2016, 'A review of fundamental principles for animal models of DOHaD research: An Australian perspective', Journal of Developmental Origins of Health and Disease, 7, pp. 449 - 472,

Journal articles | 2016

Youngson N; Lecomte V; Maloney C; Leung P; Liu J; Hesson L; Luciani F; Krause L; Morris M; Liu JJ, 2016, 'Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring', Asian Journal of Andrology, 18, pp. 930 - 936,

Journal articles | 2014

Lecomte V; Kaakoush NO; Maloney CA; Raipuria M; Huinao KD; Mitchell HM; Morris MJ, 2014, 'Changes in Gut Microbiota in Rats Fed a High Fat Diet Correlate with Obesity-Associated Metabolic Parameters.', PLoS One, 10, pp. e0126931,

Journal articles | 2014

Ng SF; Lin RCY; Maloney CA; Youngson NA; Owens JA; Morris MJ, 2014, 'Paternal high-fat diet consumption induces common changes in the transcriptomes of retroperitoneal adipose and pancreatic islet tissues in female rat offspring', FASEB Journal, 28, pp. 1830 - 1841,

Journal articles | 2013

Lecomte V; Youngson NA; Maloney CA; Morris MJ, 2013, 'Parental programming: How can we improve study design to discern the molecular mechanisms?', BioEssays, 35, pp. 787 - 793,

Journal articles | 2013

Li CCY; Young PE; Maloney CA; Eaton SA; Cowley MJ; Buckland ME; Preiss T; Henstridge DC; Cooney GJ; Febbraio MA; Martin DIK; Cropley JE; Suter CM, 2013, 'Maternal obesity and diabetes induces latent metabolic defects and widespread epigenetic changes in isogenic mice', Epigenetics, 8, pp. 602 - 611,

Journal articles | 2013

Maloney CA; Hay SM; Reid MD; Duncan G; Nicol F; Sinclair KD; Rees WD, 2013, 'A methyl-deficient diet fed to rats during the pre- and peri-conception periods of development modifies the hepatic proteome in the adult offspring', Genes and Nutrition, 8, pp. 181 - 193,

Journal articles | 2011

Lawlor KT; O''Keefe LV; Samaraweera SE; Van eyk CL; McLeod C; Maloney CA; Dang TH; Suter CM; Richards RI, 2011, 'Double-stranded RNA is pathogenic in Drosophila models of expanded repeat neurodegenerative diseases', Human Molecular Genetics, 20, pp. 3757 - 3768,

Journal articles | 2011

Maloney CA; Hay SM; Young LE; Sinclair KD; Rees WD, 2011, 'A methyl-deficient diet fed to rat dams during the peri-conception period programs glucose homeostasis in adult male but not female offspring ^1-3', Journal of Nutrition, 141, pp. 95 - 100,

Journal articles | 2010

Gosby AK; Maloney CA; Caterson ID, 2010, 'Elevated Insulin Sensitivity in Low-protein Offspring Rats Is Prevented by a High-fat Diet and Is Associated With Visceral Fat', Obesity, 18, pp. 1593 - 1600,

Journal articles | 2010

Li CCY; Maloney CA; Cropley JE; Suter CM, 2010, 'Epigenetic programming by maternal nutrition: shaping future generations', Epigenomics, 2, pp. 539 - 549,

Journal articles | 2009

Maloney CA; Hay SM; Rees WD, 2009, 'The effects of feeding rats diets deficient in folic acid and related methyl donors on the blood pressure and glucose tolerance of the offspring', British Journal of Nutrition, 101, pp. 1333 - 1340,

Journal articles | 2009

Maloney CA, 2009, 'Postnatal nutrition alters body composition in adult offspring exposed to maternal protein restriction', British Journal of Nutrition, 101, pp. 1878 - 1884,

Journal articles | 2008

Mcneil CJ; Hay SM; Rucklidge GJ; Reid M; Duncan G; Maloney CA; Rees WD, 2008, 'Disruption of lipid metabolism in the liver of the pregnant rat fed folate deficient and methyl donor deficient diets', British Journal of Nutrition, 99, pp. 262 - 271

Journal articles | 2008

Rees WD; Mcneil CJ; Maloney CA, 2008, 'The roles of PPAR’s in the fetal origins of metabolic health and disease', PPAR Research, 2008, pp. 459030-1 - 459030-8,

Journal articles | 2007

Funnell AP; Maloney CA; Thompson LJ; Keys J; Tallack M; Perkins A; Crossley M, 2007, 'Erythroid Krüppel-like factor directly activates the basic Krüppel like factor gene in erythroid cells', Molecular and Cellular Biology, 27, pp. 2777 - 2790,

Journal articles | 2007

Lobley GE; Bremner DM; Holtrop G; Johnstone AM; Maloney CA, 2007, 'Impact of high-protein diets with either moderate or low carbohydrate on weight loss, body composition, blood pressure and glucose tolerance in rats', British Journal of Nutrition, 97, pp. 1099 - 1108,

Journal articles | 2007

Maloney CA; Hay SM; Rees WD, 2007, 'Folate deficiency during pregnancy impacts on methyl metabolism without affecting global DNA methylation in the rat fetus', British Journal of Nutrition, 97, pp. 1090 - 1098,

Journal articles | 2007

Maloney CA, 2007, 'Interactions between protein and vegetable oils in the maternal diet determine the programming of the insulin axis in the rat', British Journal of Nutrition, 97, pp. 912 - 920,

Journal articles | 2007

Sinclair KD; Allegrucci C; Singh RP; Gardner DS; Sebastian S; Bispham J; Thurston A; Huntley JF; Rees WD; Maloney CA; Lea RG; Craigon J; McEvoy TG; Young LE, 2007, 'DNA methylation, insulin resistance and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status', Proceedings of the National Academy of Sciences of the United States of America, 104, pp. 19351 - 19356

Journal articles | 2006

Rees WD; Wilson FA; Maloney CA, 2006, 'Sulfur Amino Acid Metabolism in Pregnancy: The Impact of Methionine in the Maternal Diet', Journal of Nutrition, 136, pp. 1701S - 1705S

Journal articles | 2005

Maloney CA; Lilley C; Cruickshank M; McKinnon C; Hay SM; Rees WD, 2005, 'The expression of growth-arrest genes in the liver and kidney of the protein-restricted rat fetus', British Journal of Nutrition, 94, pp. 12 - 18,

Journal articles | 2005

Maloney CA; Rees WD, 2005, 'Gene-nutrient interactions during fetal development', Reproduction, 130, pp. 401 - 410,

Journal articles | 2003

Maloney CA; Gosby AK; Phuyal JL; Denyer GS; Bryson JM; Caterson ID, 2003, 'Site-specific changes in the expression of fat-partitioning genes in weanling rats exposed to a low-protein diet in utero', Obesity Research, 11, pp. 461 - 468,

Journal articles | 2003

Maloney CA, 2003, 'Maternal protein restriction increases hepatic glycogen storage in young rats', Pediatric Research, 54, pp. 413 - 418,
Conference Posters | 2021

Thiele K; Wardrop J; Birzniece V; Campbell P; Crea T; Gooi C; Gribble L; Honson V; Helme-Guizon L; Kim J; Maloney C; Peters E; Mills E; Costello E, 2021, 'Connecting Threads – Enriching the EF Community', Sydney, Australia, presented at UNSW Office of the PVC Education 2020 Learning and Teaching Forum, Sydney, Australia, 21 November 2021 - 21 November 2020,

Conference Abstracts | 2020

Billah MM; Khatiwada S; Lecomte V; Morris MJ; Maloney CA, 2020, 'Effect of high fat diet induced paternal obesity and micronutrient intervention on offspring testicular antioxidant capacity', in HUMAN REPRODUCTION, OXFORD UNIV PRESS, ELECTR NETWORK, Vol. 35, pp. 171 - 171, presented at 36th Virtual Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), ELECTR NETWORK, 05 July 2020 - 08 July 2020,

Conference Abstracts | 2019

Billah M; Khatiwada S; Lecomte V; Morris M; Maloney C, 2019, 'A Novel Micronutrient Supplement to Mitigate the Transgenerational Effects of Paternal Obesity on Body Composition of Male Offspring (P11-138-19)', in Current Developments in Nutrition, Elsevier, United States, Vol. 3, pp. nzz048.p11-138-19, United States,

Conference Abstracts | 2019

Khatiwada S; Lecomte V; Morris M; Maloney C, 2019, 'A Novel Micronutrient Supplement to Preserve Male Metabolic Health and Prevent Fatty Liver (P21-007-19)', in Current Developments in Nutrition, Elsevier, United States, Vol. 3, pp. nzz041.p21-007-19, United States,

Conference Papers | 2017

Chowdhury SS; Bahari H; Caruso V; Maloney CA; Morris MJ, 2017, 'Can voluntary exercise improve renal changes in offspring induced by maternal obesity', in FASEB JOURNAL, WILEY, IL, Chicago, presented at Experimental Biology (EB) Annual Meeting, IL, Chicago, 22 April 2017 - 26 April 2017,

Conference Papers | 2017

Kaakoush NO; Lecomte V; Maloney CA; Morris MJ, 2017, 'Chronic exposure to an obesogenic diet alters host gene expression and microbiome in the esophagus', in HELICOBACTER, WILEY, FRANCE, Bordeaux, presented at 30th International Workshop of the European-Helicobacter-and-Microbiota-Study-Group (EHMSG) on Helicobacter and Microbiota in Inflammation and Cancer, FRANCE, Bordeaux, 07 September 2017 - 09 September 2017,

Conference Abstracts | 2017

Youngson NA; Lecomte V; Maloney CA; Morris KV; Morris MJ, 2017, 'RNA-SEQUENCING TO DISCOVER NOVEL LONG-NON CODING RNA (LNCRNA) ASSOCIATED WITH OBESITY IN RAT LIVER', in JOURNAL OF GENE MEDICINE, WILEY, AUSTRALIA, Univ Technol Sydney, Sydney, Vol. 20, presented at Joint 10th Annual Scientific Meeting of the Australian-Gene-and-Cell-Therapy-Society (AGCTS) and Australasian-Society-for-Stem-Cell-Research (ASSCR), AUSTRALIA, Univ Technol Sydney, Sydney, 24 May 2017 - 26 May 2017,

Conference Abstracts | 2014

Lecomte V; Maloney CA; Wang K; Morris MJ, (ed.), 2014, 'Male offspring from obese fathers develop growth defects associated with perturbation of the lipid metabolism', in Obesity Research & Clinical Practice, Elsevier, Sydney, Vol. 8, presented at Australian and New Zeeland Obesity Society (ANZOS) meeting 2014, Sydney, 16 October 2014 - 18 July 2015,

Conference Posters | 2014

Lederman O; Rosenbaum S; Maloney C; Treen L; Wilson S; Curtis J; Ward PB, 2014, 'Physical activity, physical fitness and sleep quality in youth with at-risk mental states: a cross-sectional study', Vol. 8, pp. 132 - 132,

Conference Abstracts | 2013

Maloney CA; Lecomte V; Youngson NA; Morris MJ, (ed.), 2013, 'Effects of paternal obesity on F1 female offspring', in Obesity Research & Clinical Practice, Elsevier, Merlbourne, Vol. 7, presented at Australian and New Zeeland Obesity Society (ANZOS) meeting, Merlbourne, 17 October 2013 - 19 October 2013,

Conference Presentations | 2007

Maloney CA; Hay SM; Rees WD, 2007, '3C-6 Insulin resistance is programmed in the periconception period by a maternal diet deficient in methyl donors', Vol. 83, pp. S62 - S62

Conference Presentations | 2007

Maloney CA; Hay SM; Rees WD, 2007, 'Insulin resistance is programmed in the periconception period by a maternal diet deficient in methyl donors', Vol. 83, pp. S62 - S62,

Conference Posters | 2007

Maloney CA; Lilley C; Hay SM; Rees WD, 2007, 'P2-30 Prenatal protein restriction does not alter insulin-stimulated lipogenesis in isolated epididymal fat cells from the rat', Vol. 83, pp. S137 - S137

Conference Posters | 2007

Maloney CA; Lilley C; Hay SM; Rees WD, 2007, 'Prenatal protein restriction does not alter insulin-stimulated lipogenesis in isolated epididymal fat cells from the rat', Vol. 83, pp. S137 - S137,

Conference Posters | 2007

McNeil CJ; Maloney CA; Hay SM; Rees WD, 2007, 'Sources of dietary protein and lipid interact to modify maternal and fetal development in the pregnant rat', CAMBRIDGE UNIV PRESS EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND, Vol. 66, pp. 21A - 21A, CAMBRIDGE UNIV PRESS EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND,

Conference Posters | 2006

Rees WD; Hay SM; McNeil CJ; Maloney CA, 2006, 'Folate-deficient diets fed to pregnant rats cause changes in the mRNA associated with lipid metabolism in the fetus.', CAMBRIDGE UNIV PRESS EDINBURGH BLDG, SHAFTESBURY RD, CB2 2RU CAMBRIDGE, ENGLAND, Vol. 65, pp. 79A - 79A, CAMBRIDGE UNIV PRESS EDINBURGH BLDG, SHAFTESBURY RD, CB2 2RU CAMBRIDGE, ENGLAND,

Conference Papers | 2005

Gambling L; Maloney CA; Andersen HS; McArdle HJ, 2005, 'Maternal iron deficiency during pregnancy in the rat induces high blood pressure, obesity and dyslipidaemia in her offspring', in Pediatric Research, INT PEDIATRIC RESEARCH FOUNDATION, INC, INT PEDIATRIC RESEARCH FOUNDATION, INC 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 USA, pp. 1024 - 1024, presented at 3rd International Congress on Developmental Origins of Health and Disease, INT PEDIATRIC RESEARCH FOUNDATION, INC 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 USA, 16 November 2005 - 19 November 2005,

Conference Papers | 2005

Hay SM; Maloney CA; Rees WD, 2005, 'Dietary folate, methionine and chotine deficiency increases plasma homocysteine and modifies lipid metabolism in the dam, changing insulin in the rat fetus', in PEDIATRIC RESEARCH, INT PEDIATRIC RESEARCH FOUNDATION, INC, INT PEDIATRIC RESEARCH FOUNDATION, INC 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 USA, pp. 1114 - 1114, presented at 3rd International Congress on Developmental Origins of Health and Disease, INT PEDIATRIC RESEARCH FOUNDATION, INC 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 USA, 16 November 2005 - 19 November 2005,

Conference Papers | 2005

Maloney CA; Czopek A; Lilley C; Hay SM; Rees WD, 2005, 'Protein and fatty acid composition of the maternal diet impacts on the developing insulin axis in the rat', in PEDIATRIC RESEARCH, INT PEDIATRIC RESEARCH FOUNDATION, INC, INT PEDIATRIC RESEARCH FOUNDATION, INC 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 USA, pp. 1113 - 1113, presented at 3rd International Congress on Developmental Origins of Health and Disease, INT PEDIATRIC RESEARCH FOUNDATION, INC 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 USA, 16 November 2005 - 19 November 2005,

Conference Posters | 2004

Gosby AK; Maloney CA; Bryson JM; Caterson ID, 2004, 'Adiponectin concentrations in offspring exposed to maternal protein restriction', Munich, Germany, Vol. 47, pp. A235 - A235, presented at 40th EASD Annual Meeting of the European Association for the Study of Diabetes, Munich, Germany, 05 September 2004 - 09 September 2004

Conference Presentations | 2004

Gosby AK; Maloney CA; Bryson JM; Caterson ID, 2004, 'Adiponectin concentrations in offspring exposed to maternal protein restriction', Vol. 47, pp. A235 - A235, presented at 40th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, SPRINGER 233 SPRING STREET, NEW YORK, NY 10013 USA, 05 September 2004 - 09 September 2004,

Conference Papers | 2003

Maloney CA; Gosby AK; Phuyal JL; Bryson JM; Caterson ID, 2003, 'Altered substrate partitioning in 3 month old rats exposed to a low protein diet in utero.', in PEDIATRIC RESEARCH, INT PEDIATRIC RESEARCH FOUNDATION, INC, INT PEDIATRIC RESEARCH FOUNDATION, INC 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 USA, pp. 40A - 40A, presented at 2nd World Congress on Dietal Origins of Adult Disease, INT PEDIATRIC RESEARCH FOUNDATION, INC 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 USA, 07 June 2003 - 10 June 2003,

Conference Presentations | 2001

Gosby AK; Maloney CA; Phuyal JL; Bryson JM; Caterson ID, 2001, 'The effect of maternal protein restriction on hepatic glycogen metabolism in weanling rats', Vol. 44, pp. A29 - A29, SPRINGER-VERLAG 175 FIFTH AVE, NEW YORK, NY 10010 USA,

Conference Presentations | 2001

Maloney CA; Gosby AK; Phuyal JL; Bryson JM; Caterson ID, 2001, 'Tissue specific expression of acetyl-CoA carboxylase, fatty acid synthase and carnitine palmitoyl transferase 1 in weanling rats exposed to a low protein diet in utero', Vol. 44, pp. A29 - A29, SPRINGER-VERLAG 175 FIFTH AVE, NEW YORK, NY 10010 USA,

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