51³Ô¹Ïapp

1. Gibson, G.D., Prasad, A.A., Jean-Richard-dit-Bressel, P., Yau, J.O., Millan, E.Z., Liu, S., Campbell, E.J., Marchant, N.J., Power, J.M., Lawrence, A.J., & McNally, G.P. Segregated accumbens shell output pathways promote versus prevent relapse to alcohol seeking, accepted, Neuron IF: 13.97

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Significance: Ìýshows anatomical and functional segregation of AcbSh output pathways to ventral tegmental area pathway promotes relapse whereas whereas the lateral hypothalamus pathway prevents in relapse.

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2. Prasad, A.A., & McNally GP. Ventral pallidum output pathways in context-induced reinstatement of alcohol seeking. The Journal of Neuroscience,Ìý2016 Nov 16;36(46):11716-11726. IF: 6.747

Significance: This paper showed that VP output pathways to the subthalamic nucleus and also to the ventral tegmental area are necessary for reinstatement of alcohol seeking.Ìý

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3. Khoo, S. Y., Gibson, G. D.,ÌýPrasad, A. A., & McNally, G. P. (2016). How contexts promote and prevent relapse to drug seeking.ÌýGenes Brain Behavior doi:10.1111/gbb. 12328

Significance: Comprehensive review of the behavioural and brain mechanisms enabling contexts to promote and prevent relapse to drug seeking.Ìý

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4. Morello, F., Prasad, A.A., Vieira de Sa, R., Anton-Bolanus, N., Leyva-Diaz, E., Renberg, K., Adolfs, Y., Tissir, F., Lopez-Bendito, G., & Pasterkamp J (2015). Frizzled3 controls axonal polarity and intermediate target entry during striatal pathway development. The Journal of Neuroscience, 35, 14205-14219. IF: 6.747, Cover of The Journal of NeuroscienceÌýÌý

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Significance: Established the embryonic ontogeny of the two main striatal pathways and identified novel roles for the axon guidance receptor Frizzled3 in uncharacterized aspects of striatal pathway formation

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5. Khoo, A.T., Gibson, G.S., Prasad, A.A., & McNally, G.P. (2015). Role of the striatopallidal pathway in renewal and reacquisition of alcohol-seeking. Behavioral Neuroscience, 129, 2 - 7. ÌýIF: 2.728,

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Significance: The first paper using optogenetics in freely moving animals published from Australia. It showed that the striatopallidal pathway, previously thought to be obligatory for all forms of relapse, does not mediate context-induced reinstatement. Instead, a different pallidal input must be important for this relapse.

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6. Prasad, A.A., & McNally GP. Effects of vivo morpholino knockdown of lateral hypothalamus orexin/hypocretin on renewal of alcohol seeking. PLoS One. 2014 9, e110385 IF: 3.534

Significance: Shows relevance of proteins other than orexin within the lateral hypothalamus that may contribute to drug seeking behaviour.

7. Blakely BD, Bye CR, Fernando CV, Prasad, A.A., Pasterkamp RJ, Macheda ML, Stacker SA, Parish CL. (2013). Ryk, a receptor regulating Wnt5a-mediated neurogenesis and axon morphogenesis of ventral midbrain dopaminergic neurons. Stem Cells Development, 22, 2132-2144.Ìý IF: 3.727

Significance: Shows multiple role of Wnt5a on the development of dopaminergic neurons.

8. Prasad, A.A., Fenstermaker A, Bechara A, Adolfs Y, Tissir F, Goffinet A, Zou Y, & Pasterkamp RJ. (2010). Wnt-Planar Cell Polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem. The Journal of Neuroscience, 30, 16053-16064. ÌýÌýFirst-co-authorship. Featured article and Cover. IF: 6.747, feature and cover of The Journal of Neuroscience.

Significance: The first paper to demonstrate the molecular mechanism regulating the orientation of dopaminergic neurons. Ìý

9. Prasad A.A., Pasterkamp RJ. (2009). Axon guidance in the dopamine system. Advanced Experimental Medical Biology. 651, 91-100.

Significance: Comprehensive description of ontogeny of dopaminergic axons.

10. Kolk SM, Gunput RA, Tran TS, van den Heuvel DM, Prasad, A.A., Hellemons AJ, Adolfs Y, Ginty DD, Kolodkin AL, Burbach JP, Smidt MP, Pasterkamp RJ. (2009). Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting. The Journal of Neuroscience. 29, 12542-57. IF: 6.747

Significance: Describes the crucial role for Semaphorin 3F in development of dopaminergic circuitry.

11. Pietersen AM, Evers B, Prasad, A.A., Tanger E, Cornelissen-Steijger P,Jonkers J, van Lohuizen M. (2008). Bmi1 regulates stem cells and proliferation and differentiation of committed cells in mammary epithelium. Current Biology, 18, 1094-1099. IF: 9.571

ÌýSignificance: A detailed study of Bmi1 knockout and overexpression in mammary stem cells.