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The importance of twin studies

The so called ‘nature vs nurture’ debate isn’t new. 

In fact, twin studies have become a unique research tool used by geneticists and psychologists to evaluate the influence of genetics and the effect of a person's shared environment (family) and unique environment (the individual events that shape a life) on a particular trait. 

“With twin studies, it’s important to recruit both identical and non-identical twins,” says A/Prof. Gatt. “Identical twins share 100 per cent of their genetics and if they're grown up together, they share the same environment. Whereas with the non-identical twins, they only have 50 per cent shared genetics, but they also have that common environment.”

“In this study, we wanted to bridge lots of gaps in the literature and provide a more robust and thorough picture of how our genetics and environmental factors impact the expression of brain activity during emotional and cognitive tasks, by analysing twins,” says Dr Park.

Cognitive and emotional tasks

The most recent paper is from the , which recruited 1600 identical and non-identical twins from across the country in 2009 and is led by A/Prof. Gatt. 

A subset of the original cohort participated in this particular study, with a total of 270 adult twins taking part. 

“We get participants set up on the fMRI scanner bed which is fitted with goggles that enable them to see the tasks in front of them. The functional tasks involve them viewing different images, different stimuli, through the goggles,” says A/Prof. Gatt. 

While the participants were completing the tasks, the fMRI machine was scanning their brain to measure its activity. 

The twins completed a total of five tasks. Two were linked to emotional responses, such as reactions to various expressions of different faces, and the other three were associated with cognition, such as the ability to sustain attention and short-term memory. 

Processing the fMRI scans show you which part of the brain light up for different processes, and how strongly the brain is activated can be measured on a scale. 

“So individuals who show a lot of activation in that region have a higher number, whereas those with lower activation have a smaller number. We then use these figures to carry out what we call ‘twin modeling’ processes,” says Dr Park. “This is where we use statistics to break down how much of a role genetics and environment contributes to that number.”

Twin modelling results

Twin modelling methods revealed two key findings in their analysis of the results. 

Firstly, the researchers looked at the genetic versus environmental influence on each individual task. “We know that we use different brain networks for different processes – for example, processing either a crying face or a happy face is going to use different regions in the brain compared to trying to remember someone’s phone number,” says A/Prof. Gatt. “But we found that for some of these networks, genetics plays a small to moderate, but significant role. And for other processes, it’s only the environment that determines brain function.”

The second part of the analysis found that there were similarities in the genetic and environmental factors that underpinned different tasks. 

"For example, we discovered that how the brain processes fear and happiness (which was measured in the emotional tasks) and our ability to sustain attention (which was measured in the cognitive tasks), have some shared genetic factors,” says Dr Park. “This suggests that some common genetic features may underpin these very different processes.”

In contrast, the team also found that our ability to sustain our attention and our working memory have some of the same environmental contributions, suggesting that life experiences – which come from your environment – play a significant role in how brain activity is expressed for these two processes.

Mental wellbeing and resilience

While it’s clear that both our genetics and life experiences are important in determining how our brain functions, the puzzle is far from solved.

“There’s still so much more to find out!” says Dr Park. The current participants have already been followed up more recently and have performed the same tasks again after 10 years. A/Prof. Gatt, Dr Park and their team will be reassessing the results to see how the influences of genetics and environment on these brain processes change over time.

“All these results paint a complex picture of the relationship between genes and environment that give rise to the brain activity underlying our cognition and emotion,” says A/Prof. Gatt. But knowing more precise details may help to develop personalised intervention approaches in order to promote, for instance, higher mental wellbeing, or reduced psychological distress.

In fact, the ongoing TWIN-E study focuses more broadly on mental wellbeing and resilience. “So, what we're using this data for, beyond looking at genes and environment, is actually predicting mental wellbeing and resilience trajectories over time, and seeing how differences in markers like brain function and structure might profile people who are a bit more resilient or at more risk to a mental health problem,” says A/Prof. Gatt. 

Understanding how much of our life experiences influences certain processes versus the influence of genetics is important when knowing what factors we can change and control, which is particularly significant for people with mood and anxiety disorders, explains A/Prof. Gatt. “If someone has a tendency to attend to negative stimuli more than positive, and we know that there's an element of environment contributing to that, with intervention or training, it’s potentially something we can target and improve for the better.”